Effectiveness of Autologous Fibrin Tissue Adhesive in Reducing Postoperative Blood Loss during Total Hip Arthroplasty: A Prospective Randomised Study of 100 Cases

Mawatari, Masaaki; Higo, Takami; Tsutsumi, Yukihiko; Shigematsu, Masamori; Hotokebuchi, Takao

doi:10.1177/230949900601400202

Cited by 47 publications

(31 citation statements)

References 27 publications

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“…Fibrin spray and tranexamic acid have both been reported to reduce blood loss in arthroplasty (Benoni et al 2001, Ho and Ismail 2003, Husted et al 2003, Johansson et al 2005, Niskanen and Korkala 2005, Mawatari et al 2006, Rajesparan et al 2009). Prior to the time of commencement of our study, each of the treatments had been used for some patients at the hospital where the study was conducted.…”

Section: Discussionmentioning

confidence: 99%

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Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

McConnell¹,

Shewale²,

Munro³

et al. 2011

Acta Orthopaedica

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Background and purpose Previous studies have shown that either fibrin spray or tranexamic acid can reduce blood loss at total hip replacement, but the 2 treatments have not been directly compared. We therefore conducted a randomized, controlled trial.Patients and methods In this randomized controlled trial we compared the effect of tranexamic acid and fibrin spray on blood loss in cemented total hip arthroplasty. 66 patients were randomized to 1 of 3 parallel groups receiving (1) a 10 mg/kg bolus of tranexamic acid prior to surgery, (2) 10 mL of fibrin spray during surgery, or (3) neither. All participants except the surgeon were blinded as to treatment group until data analysis was complete. Blood loss was calculated from preoperative and postoperative hematocrit.Results Neither active treatment was found to be superior to the other in terms of overall blood loss. Losses were lower than those in the control group, when using either tranexamic acid (22% lower, p = 0.02) or fibrin spray (32% lower, p = 0.02).Interpretation We found that the use of tranexamic acid at induction, or topical fibrin spray intraoperatively, reduced blood loss compared to the control group. Blood loss was similar in the fibrin spray group and in the tranexamic acid group.ClinicalTrials.gov identifier: NCT00378872EudraCT identifier: 2006-001299-19Regional Ethics Committee approval: 06/S0703/55, granted June 6, 2006

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Section: Discussionmentioning

confidence: 99%

“…It has been shown to be safe and effective in reducing blood loss and requirements for transfusion after hip arthroplasty (Wang et al 2003, Mawatari et al 2006). It is considerably costlier than tranexamic acid.…”

Section: Discussionmentioning

confidence: 99%

Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

McConnell¹,

Shewale²,

Munro³

et al. 2011

Acta Orthopaedica

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“…Fibrin has high biocompatibility, biodegradability, no toxicity, and has long been used as a clinical substance for bleeding control. Fibrin is also known for its successful use as an injectable carrier for generating neocartilage [Keller et al, 1985;Mawatari et al, 2006]. Fibrin can maintain the shape of an articulation for approximately 5 min after its injection, thus causing the atelocollagen to remain in the injected sites.…”

Section: Discussionmentioning

confidence: 99%

Autologous Collagen-Induced Chondrogenesis Using Fibrin and Atelocollagen Mixture

Jeong¹,

Shetty²,

Kim³

et al. 2013

Cells Tissues Organs

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For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture transplanted to cartilage defects. A circular, articular cartilage defect 4 mm in diameter was made in the trochlear region in each of 20 New Zealand white rabbits. The 10 rabbits in the control group were kept without treatment and the 10 rabbits in the experimental group underwent injection of atelocollagen mixed with fibrin. At week 12 following surgery the cartilage was observed and histologically compared in both groups. The surface of the newly generated cartilage was very smooth and even, and we also noted that the entire area was completely regenerated in the experimental group. The control group showed incomplete and irregular cartilage formation in the defect. Regarding the histological scoring, comparison of the two groups differed significantly (p < 0.001). Injection of a mixture of atelocollagen and fibrin used to treat articular cartilage defects of the knee appears to be an effective method for cartilage regeneration.

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“…Everts et al [13] combined autologous platelet gel with fibrin sealant to enhance the efficacy of TKA demonstrating that this combination improves range of motion, decreased length of stay and reduced incidence of arthrofibrosis in treated patients compared with controls. An alternative approach to commercial fibrin sealants is the preparation of fibrin tissue adhesive from preoperative autologous blood donation [14]; however, implementing this technique in daily routine of clinical practice in orthopaedic surgery has not been successful. The number of elderly patients undergoing orthopaedic surgery has increased within the past years.…”

Section: Introductionmentioning

confidence: 98%

Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty

Kluba

Fiedler

Kunze

et al. 2012

Arch Orthop Trauma Surg

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Effectiveness of Autologous Fibrin Tissue Adhesive in Reducing Postoperative Blood Loss during Total Hip Arthroplasty: A Prospective Randomised Study of 100 Cases

Abstract: Auto-FTA is a safe and effective means of reducing perioperative blood loss in THA.

Cited by 47 publications

References 27 publications

Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

Autologous Collagen-Induced Chondrogenesis Using Fibrin and Atelocollagen Mixture

Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty

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