Effectiveness of autologous platelet-rich plasma gel in the treatment of hard-to-heal leg ulcers: a randomised control trial

Rainys, Domantas; Čepas, Adas; Dambrauskaite, Karolina; Nedzelskienė, Irena; Rimdeika, Rytis

doi:10.12968/jprp.2020.2.sup8.32

Cited by 4 publications

(9 citation statements)

References 29 publications

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“…Healing time and overall results in chronic leg ulcers were significantly better when treated with PRP, according to Helmy et al [10]; furthermore, there was no reoccurrence in the treatment group (TG) in contrast to the eleven cases in the CG. Similar results were presented by Xie et al [14] and Rainys et al [12]. According to these studies, PRP can reduce wound size, induce granulation tissue formation, and shorten hospital stay, which leads to reduced costs for both patients and hospitals.…”

Section: Discussionsupporting

confidence: 85%

“…Eleven studies investigating the application of PRP in reconstructive plastic surgery were included. Five of them treated chronic wounds or ulcers with PRP injections or gel application [10][11][12][13][14]. Two randomized controlled trials (RCTs) compared PRP application to conventional fixation with split-thickness skin grafts (STSGs) [15,16].…”

Section: Resultsmentioning

confidence: 99%

“…Many factors had to be considered, such as differences in number of PRP applications or the use of activators. In seventeen studies [10, 11, 13-15, 21, 24, 27, 31, 34, 35, 38, 40-42, 50, 53], double spin centrifugation was performed, 21 studies used a single spin protocol [16, 17, 19-23, 29, 30, 32, 33, 36, 37, 43-49, 51, 58], and twelve authors merely disclosed the name of the device used, or no information about this process at all [12, 18, 25, 26, 28, 39, 52, 54-57, 59]. Twenty-two authors reported the use of CaCl and/or Thrb for platelet activation [11, 13-15, 18, 19, 21, 24, 28, 30, 31, 37, 39, 42-47, 50, 51, 58].…”

Section: Resultsmentioning

confidence: 99%

“…One author applied photo-activated PRP [40]. The remaining studies did not mention this step of the process [10, 12, 16, 17, 20, 25-27, 29, 32, 33, 35, 36, 38, 41, 48, 49, 56, 59]. High variation was seen in the number of PRP treatments and in the volume of obtained/applied PRP.…”

Section: Resultsmentioning

confidence: 99%

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Platelet-Rich Plasma in Plastic Surgery: A Systematic Review

Hasiba-Pappas¹,

Tuca²,

Luze³

et al. 2022

Transfus Med Hemother

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Introduction: Platelet-rich plasma (PRP) is gaining popularity and is applied in a variety of clinical settings. This review aims to present and evaluate available evidence regarding the use of PRP in various applications in plastic surgery. Methods: PubMed, Web of Science, Medline, and Embase were searched using predefined MeSH terms to identify studies concerning the application of PRP alone or in combination with fat grafting for plastic surgery. The search was limited to articles in English or German. Animal studies, in vitro studies, case reports, and case series were excluded. Results: Of 50 studies included in this review, eleven studies used PRP for reconstruction or wound treatment, eleven for cosmetic procedures, four for hand surgery, two for burn injuries, five for craniofacial disorders, and 17 as an adjuvant to fat grafting. Individual study characteristics were summarized. Considerable variation in preparation protocols and treatment strategies were observed. Even though several beneficial effects of PRP therapy were described, significance was not always demonstrated, and some studies yielded conflicting results. Efficacy of PRP was not universally proven in every field of application. Conclusion: This study presents an overview of current PRP treatment options and outcomes in plastic surgery. PRP may be beneficial for some indications explored in this review; however, currently available data are insufficient and systematic evaluation is limited due to high heterogeneity in PRP preparation and treatment regimens. Further randomized controlled trials employing standardized protocols are warranted.

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Section: Discussionsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Platelet-Rich Plasma in Plastic Surgery: A Systematic Review

Hasiba-Pappas¹,

Tuca²,

Luze³

et al. 2022

Transfus Med Hemother

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“…e effects of two anticoagulants, A and citrate glucose solution, as well as the gender on the PRP cell count and growth factor concentration in pure ptt-rich gel supernatant are determined. Variables were associated with the assessment, but the content of a numerical analysis was lacking [3]. e innovation of this paper is to study the effects of pttrich plasma gel combined with a chitosan nanocomposite membrane loaded with bone marrow stromal cells on wound healing using a chitosan nanocomposite membrane, a nanocomposite algorithm, and the calculation method of the enthalpy of formation of high alloy nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Role of Platelet‐Rich Plasma Gel in Promoting Wound Healing Based on Medical Images of Wounds

Liu

et al. 2022

Contrast Media & Molecular Imaging

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A wound is the pathological change of soft tissue under normal skin caused by various factors, such as collision, contusion, hot crush, avulsion, corrosive chemicals, operations, excessive wound tension after operations, local pressure that cannot be relieved for a long time, liquid immersion, local infection, and rejection reactions caused by allogeneic substances. e skin itself or its underlying soft tissue loses its integrity and continuity, thus losing its normal physiological function. Medical image analysis is a medical term that refers to the interdisciplinary fields of integrated medical imaging, artificial intelligence, digital image processing and analysis, mathematical modeling, and numerical algorithms. According to the time of wound formation, they can be divided into acute and chronic wounds. e common acute wounds include lacerations caused by trauma, surgical incisions, burns, and donor sites formed after skin graft operations.is article mainly studies the role of platelet-rich plasma gel nanocomposites in promoting wound healing. It is proven that ptt-rich plasma gel can significantly promote tissue repair and regeneration and accelerate wound healing in patients with severe burns. e atomic number of the nanocomposite has a better treatment effect on the nanoparticle approach. In this paper, chitosan nanocomposite membrane, nanocomposite algorithm, and the calculation method of enthalpy of formation of high alloy nanomaterials were used to study the role of ptt-rich plasma gel combined chitosan nanocomposite membrane loaded bone marrow stromal cells in promoting wound healing, and its effects were applied to the repair of special site burns, special burns, and different age burns. Good wound repair benefits from the correct treatment of the wound, which directly affects the stability and development of the internal environment. e difference in healing time between the two groups was statistically significant, and the recovery time of the PRP group was 0.001 less than that of the control group. e results showed that the wound healing time of the PRP group was significantly shorter than that of the control group (P < 0.05); after treatment, the content of VEGF in the wound tissue of the two groups increased, especially in the PRP group; the effective rate of the PRP group was 75.0%, which was higher than 68.8% of the control group. It can play an important role in the regulation of expression and the pathophysiological process of wound healing.

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