Effectiveness of Botulinum-A Toxin for the Treatment of Refractory Overactive Bladder in Children

Abstract

Intravesical BTX-A injection appears to be safe and useful in children presenting with idiopathic overactive drug-resistant bladder.

Urinary incontinence in children: botulinum toxin is a safe and effective treatment option

“…This is consistent with previous studies in children with OAB [11,12]. From our FBC functional bladder capacity a One female patient experienced personality changes and dry mucous membranes data, male patients had higher rates of both complete and partial success.…”

“…This has been observed previously [11,12,14,15]. It is interesting that there was a significant improvement in nocturnal symptoms where they existed.…”

“…Treatment failure within these subgroups revealed that all patients were female. Previous studies in children have included only patients with medication resistance or intolerant to the side effects [11,12]. Our study included patients in whom compliance and medication dependency were major problems.…”

“…Both studies have shown an excellent response to treatment in medication-resistant OAB. Some patients did require repeated injections; however, the longterm outcome resulted in high success rates with minimal side effects [11,12].…”

What Is the Evidence for the Use of Botulinum Toxin in Idiopathic Detrusor Overactivity?

“…Only a small number of studies have reported the use of BTX-A in children with IDO, and only two have described more than 10 patients [27,28]. Hoebeke et al [27] utilized 100 U of onabotulinumtoxinA, and of 15 patients in the study, 3 were deemed not to have responded.…”