Effectiveness of chemotherapy and radiotherapy for laryngeal preservation in advanced laryngeal cancer: a meta-analysis and systematic review

Luo, Xiaoning; Chen, Liang-Si; Zhang, Siyi; Lu, Zhongming; Huang, Yan

doi:10.1007/s11547-015-0547-8

Cited by 20 publications

(17 citation statements)

References 31 publications

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“…An RCT conducted in France including patients with T3 primary laryngeal tumors demonstrated significantly improved survival in the group undergoing immediate surgery compared with patients receiving induction chemotherapy followed by RT (25). Previous studies revealed that the 5-year OS and DFS rates in patients with advanced LC were 60.8-71.6 and 41.0-57.8%, respectively, with regard to different treatment regimens (23,27). The present study demonstrated that the 5-year OS and DFS rates were 55.2 and 47.4%, respectively, which supported previously published data.…”

Section: Treatment Groups No Of Patients (%) ----------------------supporting

confidence: 91%

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Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma

et al. 2019

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Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 and 2010 was conducted. Of the 232 eligible patients, 167 patients (72%) received surgery alone, whereas 65 patients (28%) received surgery + adjuvant CRT. In the overall cohort, the 5-and 10-year overall survival (OS) rates were 55.2 and 48.3%, respectively. Multivariate analysis revealed that the clinical stage was significantly associated with OS. However, the N classification was an independent indicator in disease-free survival and laryngeal cancer-specific survival. In those patients with stage IV disease, patients receiving adjuvant CRT exhibited a markedly improved survival benefit compared with patients receiving surgical treatment only, following propensity score matching of the data (P<0.05). The application of adjuvant CRT confers additional survival benefits in comparison with surgery-only treatment regimens for advanced LSCC. However, additional prospective studies are required.

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Section: Treatment Groups No Of Patients (%) ----------------------supporting

confidence: 91%

“…with chemoradiotherapy for advanced LC (21,22). However, different treatment modalities or combinations have varied in different developing and developed countries (23). Several clinical trials have been conducted to investigate the optimal treatment for LC (21,24,25).…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma

et al. 2019

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“…Chemotherapy is usually used in the neoadjuvant, adjuvant, or primary treatment options of advanced LSCC . The common chemotherapeutic drugs use for the treatment of LSCC which includes Fluorouracil (5‐Fu), placetatin, taxel, gemzar and cisplatin.…”

Section: Introductionmentioning

confidence: 99%

Aurora kinase A induces chemotherapy resistance through revival of dormant cells in laryngeal squamous cell carcinoma

et al. 2019

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Background: Chemotherapy resistance was an important tumor metastasis mechanism. Methods: Cell Counting Kit-8 assay and plate colony formation assay were applied to examine the proliferation of laryngeal squamous cell carcinoma (LSCC). Immunofluorescent staining and Western blotting were carried out to show the expression of related proteins. Wound healing, migration, and invasion assays were used to examine the mobility, migration, and invasion of LSCC. Results: Downregulated Aurora kinase A (AURKA) increased chemotherapy sensitivity and reduced the ability of mobility, migration, and invasion of Hep2 cells, while upregulated AURKA possessed opposite results. Hep2/5-Fu cells possessed dormancylike properties and upregulated AURKA in Hep2/5-Fu cells (Hep2/5-Fu/AURKA cells) revived dormant state. Furthermore, Erk1/2 was restrained in Hep2/5-Fu cells and activated in Hep2/5-Fu/AURKA cells. Moreover, Erk1/2 accelerated the ability of mobility, migration, and invasion in Hep2/5-Fu/AURKA cells. Conclusion: AURKA activated dormant state to induce chemotherapy resistance and promoted metastasis of LSCC through Erk1/2 pathway.Laryngeal squamous cell carcinoma (LSCC), arisen from the larynx epithelium, is one of the most common cancer worldwide. 1 Despite the improvement of current chemotherapy, surgery, and radiotherapy, the 5-year survival rate of LSCC is only approximately 60%. 2 The main death cause of LSCC is metastasis and relapse. 3 Therefore，elucidating molecular mechanisms to design novel strategies is very essential for improving survival of LSCC.Chemotherapy is usually used in the neoadjuvant, adjuvant, or primary treatment options of advanced LSCC. 4 The common chemotherapeutic drugs use for the treatment of LSCC which includes Fluorouracil (5-Fu), placetatin, taxel, gemzar and cisplatin. Among them, 5-Fu has been used for the treatment of head and neck, gastric, breast, and colorectal cancers. 5 Despite the fact that the effect of these chemotherapeutic drugs is prominent, chemotherapy resistance of cancers is the main cause of relapse and mortality. 6,7 Thus, it is essential to research new targets to improve the chemotherapy effect of LSCC.Aurora kinase A (AURKA) is a homolog of aurora/ Ipl1-related kinase which is located at chromosome 20q13.2. 8 More and more researchers had proved AURKA, an oncogene, contributed to plenty of malignant cancers, including head and neck, bladder, ovarian, colon, breast, and pancreatic cancers. 3,[9][10][11][12][13] In our previous study, AURKA was overexpressed in LSCC and associated with regional lymph node metastasis and late clinical stage. 3 Moreover, AURKA might activate dormant state to promote the metastasis of Li-yun Yang and Ya-min Shan contributed equally to this article.

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“…The Cochran Q and I 2 test was used to assess heterogeneity of the included studies. Cochran Q P <0.10 or I 2 >50% was defined as heterogeneity of the included studies [ 16 ]. I 2 is the proportion of total variation detected between included studies.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis

Kim

Park

Jeong

et al. 2018

Clin Exp Otorhinolaryngol

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Objectives This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses.Methods Twenty-five retrospective case-series studies were included in these analyses. Treatment strategies were classified as total laryngectomy (TL), open partial laryngectomy (PL), transoral laser microsurgery (TLM), chemo-radiation therapy (CRT), and radiation therapy (RT) alone.Results The overall survival rate and disease-specific survival rate among laryngeal preservation treatments did not differ from the overall survival rate of TL. However, the local control rate was lower with RT than TL and PL, and laryngeal preservation rates of TLM and CRT were higher than RT alone.Conclusion Consideration of preservation of laryngeal function is necessary when treating T3 glottic squamous cell carcinoma. PL, TLM, and, CRT are considered more appropriate initial laryngeal preservation strategies if available.

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Effectiveness of chemotherapy and radiotherapy for laryngeal preservation in advanced laryngeal cancer: a meta-analysis and systematic review

Cited by 20 publications

References 31 publications

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma

Aurora kinase A induces chemotherapy resistance through revival of dormant cells in laryngeal squamous cell carcinoma

Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis

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