Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review

Chen, Pei‐En; Liu, Chia-Yu; Chien, Wu-Hsiung; Chien, Ching‐Wen; Tung, Tao‐Hsin

doi:10.1155/2019/9896757

Cited by 24 publications

(15 citation statements)

References 18 publications

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“…To date, there have been multiple narrative reviews exploring the applications of TC and derived dietary supplements for human health ( 40 , 67 ), exercise recovery and performance ( 67 – 70 ). Furthermore, several systematic reviews have found favorable effects of TC supplementation on systolic blood pressure and systemic markers of inflammation ( 71 ), uric acid and gout ( 72 ) and endurance exercise performance ( 73 ). However, it is hard to compare the dose of bioactive compounds provided across studies since the methods utilized to analyse the composition of the TC supplements provided are highly variable.…”

Section: Introductionmentioning

confidence: 99%

Review of Analytical Methods and Reporting of the Polyphenol Content of Tart Cherry Supplements in Human Supplementation Studies Investigating Health and Exercise Performance Effects: Recommendations for Good Practice

et al. 2021

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Tart cherries (TC) are a rich source of polyphenols that elicit antioxidant and anti-inflammatory effects. As a consequence, the effects of TC derived supplements on markers of human health, exercise performance and sleep have been investigated. Supplementation protocols have been highly variable across studies and the dose of bioactive compounds used has often been poorly characterized. Specific and non-specific analytical methods were employed for measuring the total polyphenol and anthocyanin content in TC supplements. This review critically analyses the supplementation protocols and the analytical methods used for the characterization of TC supplements, culminating in recommendations for good practice in the analysis and reporting of the polyphenol content and profile of TC products. A literature search was conducted using PubMed/Medline and Web of Science up to May 4th, 2020, including studies published in all years prior. Only articles written in English that provided a TC dietary supplement as opposed to fresh whole TC were included in this review. Forty-three studies were identified as eligible and included for analysis in this review. The studies investigated the effects of TC supplementation on various aspects of human health, exercise recovery and performance and sleep. Twenty studies conducted an analysis of TC supplement and reported total polyphenol/anthocyanin content. Six studies did not report the polyphenol content of the TC supplement used. Seventeen studies reported the TC supplement polyphenol content but this was derived from previously published studies and presumably different supplement batches. The duration of the supplementation protocol ranged from acute supplementation to 84 days, meanwhile the total polyphenol and anthocyanin dose ranged from 143 to 2,140 mg/day and 15 to 547 mg/day, respectively. Due to the variety of specific and non-specific analytical methods used, the relative efficacy of different doses and polyphenol blends cannot reliably be extrapolated from critical analysis of the literature. Future studies should conduct an analysis of the study supplement batch. In addition to analysis and reporting of total polyphenol content, specific analytical methods such as HPLC UV/MS should be used to quantify total and individual anthocyanin contents.

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Section: Introductionmentioning

confidence: 99%

Review of Analytical Methods and Reporting of the Polyphenol Content of Tart Cherry Supplements in Human Supplementation Studies Investigating Health and Exercise Performance Effects: Recommendations for Good Practice

et al. 2021

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“…The methodology was written based on several studies published ( 5 – 7 ).…”

Section: Methodsmentioning

confidence: 99%

The Relationship Between Fragility Fractures and Pain Experience: A Systematic Review

Chen

Chien²,

Tung

2021

Front. Med.

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Purpose: This systematic review is conducted to explore the relationship between fragility fractures and pain experience.Methods: We searched for relevant studies on Pubmed, Embase, Web of Science, and the Cochrane library without restrictions on language from inception until February 4th, 2021. The risk of bias and methodological quality was evaluated using the Newcastle-Ottawa Scale and ROBINS-I tool.Results: Twenty-one studies were included in this systematic review. The so-called study reported participants with continuous post-fracture pain. The included studies showed that post- fractured pain can decrease with time, however, the continual pain can last at least 1 year even longer, and some participants would need to self-manage pain. Moreover, the limited range of motion was considered as a factor that might distress the normal development of daily activities.Conclusions: The current evidence could not fully support that pain continues to influence patients' lives after a fragility fracture. However, it still showed the pain might come with fracture. The findings also could be useful to help health care providers better recognize and manage this clinical consequence of fractures. Nonetheless, future large-scale longitudinal studies will be required to evaluate the long-term effects of pain in fragility fractures.

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“…An animal study of 2 weeks showed that tart cherry juice treatment reduced the serum uric acid levels in hyperuricemic rats in a time-dependent manner [ 19 ]. A system review revealed an association between cherry intake and a reduced risk of gout attacks [ 20 ]. These results implied the potential on improving hyperuricemia as well as exhibited a limitation that presents evidence is lacking in hyperuricemia population for a long treatment by tart cherry.…”

Section: Introductionmentioning

confidence: 99%

Effects of Tart Cherry Powder on Serum Uric Acid in Hyperuricemia Rat Model

Tan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Hyperuricemia, as a critical risk factor for various adverse clinical outcomes, shows a trend of increasing prevalence among young-aged population. Dietary adjuvant therapy by function foods, such as tart cherry, is promising. Thus, effects of tart cherry powder specialized in hyperuricemia were explored via establishing a hyperuricemia model in Sprague Dawley rats by cotreatment with oteracil potassium and adenine. The results indicated that low dose of tart cherry powder (0.17 g/kg·bw) showed effects on hyperuricemia by slightly decreasing serum uric acid and improving kidney injury, whereas high dose of tart cherry powder (0.50 g/kg·bw) could merely alleviate kidney injury. Meanwhile, adenosine deaminase activity rather than xanthine oxidase activity was affected at low dose, which reveals low dose of tarty cherry powder may be beneficial to hyperuricemia through reduction of ADA activity, and its reported potentials on antioxidation or anti-inflammation provide clues for further study.

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Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review

Cited by 24 publications

References 18 publications

Review of Analytical Methods and Reporting of the Polyphenol Content of Tart Cherry Supplements in Human Supplementation Studies Investigating Health and Exercise Performance Effects: Recommendations for Good Practice

Review of Analytical Methods and Reporting of the Polyphenol Content of Tart Cherry Supplements in Human Supplementation Studies Investigating Health and Exercise Performance Effects: Recommendations for Good Practice

The Relationship Between Fragility Fractures and Pain Experience: A Systematic Review

Effects of Tart Cherry Powder on Serum Uric Acid in Hyperuricemia Rat Model

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