Effectiveness of combined treatment using Spirulina and vitamin A against chronic arsenicosis in rats

Do, M. A.

doi:10.5897/ajpp12.008

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…At first all the rats were randomized, divided into 5 groups (N=12) and were identified as T0 for control group and reared with only ad libitum normal feed and water, T1 for As group were treated with sodium arsenite (NaAsO2;197.84g/mol MW, May & Baker Ltd, Dagenham, England)) at 4mg/kg body weight (BW) in drinking water daily, T2 for As plus Spirulina group were treated with same doses of As of T1 group daily and also added Spirulina (Spirulina platensis) (Tab. Spirulina®; Life Line International Company, Bangladesh) at a dose of 1 g/kg feed (Khatun et al, 2020), T3 for As plus Vitamin A group were treated with same doses of As of T1 group daily and also added Vitamin A (Capsule Retinol forte; Drug international limited; Tongi Gazipur; Bangladesh) simultaneously at a dose of 2500 IU/kg feed (Hossain et al, 2013) and lastly T4 for As plus Vitamin A and Spirulina group were treated with same doses of T1 group's As with Vitamin A at 2500 IU/kg feed and Spirulina (Spirulina platensis) at 1 g/kg feed. The sodium arsenite doses were chosen based on our preliminary study and also reference article (Hossain et al, 2013).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…Spirulina®; Life Line International Company, Bangladesh) at a dose of 1 g/kg feed (Khatun et al, 2020), T3 for As plus Vitamin A group were treated with same doses of As of T1 group daily and also added Vitamin A (Capsule Retinol forte; Drug international limited; Tongi Gazipur; Bangladesh) simultaneously at a dose of 2500 IU/kg feed (Hossain et al, 2013) and lastly T4 for As plus Vitamin A and Spirulina group were treated with same doses of T1 group's As with Vitamin A at 2500 IU/kg feed and Spirulina (Spirulina platensis) at 1 g/kg feed. The sodium arsenite doses were chosen based on our preliminary study and also reference article (Hossain et al, 2013). All treatments were given for 63 days (Hossain et al, 2013) because the experimental trial was conducted for 63 days.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…The sodium arsenite doses were chosen based on our preliminary study and also reference article (Hossain et al, 2013). All treatments were given for 63 days (Hossain et al, 2013) because the experimental trial was conducted for 63 days.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

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Synergistic Effects of Vitamin A and Spirulina on Arsenic Load in Rat Tissues and Blood

Md Ashraful Islam,

Md Sodrul Islam,

Md Abdul Awal

et al. 2024

Res. Agric. Livest. Fish.

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Arsenic (As) is found in contaminated groundwater as the source of pollution. In this study, 60 Long-Evans rats were used to assess the levels of As in the blood and organs and to compare the effectiveness of vitamin A and spirulina (Spirulina platensis) in preventing a chronic As accumulation. Twelve rats were assigned to each group of animals. The experimental groups were the control (T0), As (T1), As + spirulina (T2), As + vitamin A (T3), and As + spirulina + vitamin A (T4). The T1, T2, T3, and T4 groups were orally administered with sodium arsenite (NaAsO2) @ 4 mg/kg body weight (BW) for 63 days. In addition to NaAsO2, the T2 and T4 received 1 g/kg BW spirulina. The T3 and T4 received 2500 IU/kg BW vitamin A for 63 days, respectively. Four rats were euthanized in each group to evaluate the As concentration in the liver, lung, kidney, and blood at an interval of 21 days. Total As concentration was quantified from the organs using Hydride Generation Atomic Absorption Spectrophotometer (HG-AAS). The results revealed that the T0 had no visible clinical symptoms. However, after 63 days of treatment, the T1 (As only administration) accumulated more As compared to other groups. The concentration of As was highest in the blood, then in the kidney, liver, and lung. In this case, spirulina and vitamin A substantially (p<0.01) decreased the concentration of As in the rats' organs and tissues Spirulina is more effective than vitamin A in reducing As accumulation in rats. In summary, the combination of both spirulina and vitamin A has a positive impact on reducing the accumulation of chronic arsenicosis in rats compared to the individual administration of either spirulina or vitamin A alone. Vol. 10, No. 3, December 2023: 341-351

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Section: Animals and Experimental Designmentioning

confidence: 99%

Section: Animals and Experimental Designmentioning

confidence: 99%

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Synergistic Effects of Vitamin A and Spirulina on Arsenic Load in Rat Tissues and Blood

Md Ashraful Islam,

Md Sodrul Islam,

Md Abdul Awal

et al. 2024

Res. Agric. Livest. Fish.

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Antioxidant Statues, Growth and Some Physiological Performances of the Gimmizah Male Chickens Supplemented by Dietary Spirulina Platensis under Chronic Heat Stress.

Abaza

Abdallah²,

Helal

et al. 2021

Journal of Desert and Environmental Agriculture

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The present study was carried out to study the effect of Spirulina supplementation on the growth and some physiological performances of the Gimmizah males exposed to heat stress (HS). A total number of 150 male 4 weeks old Gimmizah were randomly allocated in five groups (3 replicates, 10 chicks each). The first (positive control, PC) was reared under 22-24OC and PH 45-55% and fed unsupplied basal diet, B). Whereas, the other groups were reused under HS (38°C±1; 55-65 % RH) for three successive days /wk from 11.00 a.m until 15.00 p.m, through the experimental period (4 to 14 wks of age) in a battery brooders. The first HS group was used as a negative control (NC) and fed B. The 3rd and 4rd groups fed B plus 250 and 150 mg Spirulina /kg diet, respectively. The 5 group was fed the B plus 75 mg VE /kg diet. The feed consumption was significantly decreased for all groups under HS compared with PC group, while FCR for the groups under HS (supplied with Spirulina or VE) were significantly improved compared with NC. The differential of leukocytic count for the NC group recorded the significant increase on Lymphocyte, Heterophil and the ratio of H/L compared with other groups. The concentration of globulin and activity of GSH-PX were significantly improved for the groups supplied with both levels of Spirolina under HS compared with the NC group. The highest Infections Bronchitis titer was recorded for the group supplied with VE and PC group. In conclusion, addition of 150 and 250 mg Spirulina platensis /kg diet improved performance, immunity and can be decreased the adverse effect of heat stress for Gimmizah mail during growing period (4-14 wks of age).

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Effectiveness of combined treatment using Spirulina and vitamin A against chronic arsenicosis in rats

Cited by 2 publications

References 20 publications

Synergistic Effects of Vitamin A and Spirulina on Arsenic Load in Rat Tissues and Blood

Synergistic Effects of Vitamin A and Spirulina on Arsenic Load in Rat Tissues and Blood

Antioxidant Statues, Growth and Some Physiological Performances of the Gimmizah Male Chickens Supplemented by Dietary Spirulina Platensis under Chronic Heat Stress.

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