Effectiveness of drotaverine hydrochloride in progression of labour

Thapa, Meena; Saha, Rachana; Pradhan, Amita; Shrestha, Sweety

doi:10.3126/njog.v2i2.1447

Cited by 8 publications

(9 citation statements)

References 1 publication

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“…Similar observation was found by Sharma JB et al 3 where the mean injection to delivery interval was 194 min in primipara and 412.8 min in control group. The duration of labor was markedly reduced also in the study reported by Thapa M et al 8 where the mean duration of injection to delivery interval in drotaverine group for primigravidae and multigravidae was 196.9 min and 127min respectively. Decrease in first stage of labor can be attributed to the action of drotaverine.…”

Section: Discussionsupporting

confidence: 57%

A prospective study on effectiveness of drotaverine in acceleration of labor

Dhungana

Adhikari²,

Pageni³

et al. 2019

Med. J. Pokhara Acad. Health Sci.

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Background:Labor is a naturally occurring physiological process associated with uterine contractions, effacement, dilatation of cervix and descent of presenting part. Drotaverine hydrochloride is a non-anticholinergic isoquinoline derivative which acts by elevating intracellular cyclic Adenosine Mono Phosphate (cAMP) and cyclic Guanosine Mono Phosphate (cGMP) promoting smooth muscle relaxation. Materials And Method: This was a hospital based prospective study on effectiveness of Drotaverine Hydrochloride on enhancing dilatation of cervix and acceleration of active phase of labor. The sample size was 100. Fifty cases of women in active phase of labor received injection drotaverine hydrochloride 40 mg (group i) and fifty cases of women did not receive any drug (group ii) among those at term with singleton pregnancy and vertex presentation. Variables like maternal age, interval between administration of drug and delivery, mode of delivery, apgar score at 5 minutes, NCU (Neonatal Care Unit) admission and neonatal outcomes were recorded. Data analysis was done with the help of SPSS program. Results: The mean interval between drug adminstration to delivery in primipara and multipara in group i was 3.05 hours and 2.31 hours while in group ii was 4.5 hours and 3.75 hours respectively. The mean interval between drug adminstration and delivery was shorter in both groups of multipara. In group i, 96% had normal delivery and 4 % had vaccum delivery and in group ii 90% and 10% had normal delivery and vacuum delivery respectively. None of the participants had caeseraian section. There were no perinatal mortalities. Conclusion: The administration of drug Drotaverine Hydrochloride is effective in shortening duration of labor with favorable feto-maternal outcome.

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Section: Discussionsupporting

confidence: 57%

A prospective study on effectiveness of drotaverine in acceleration of labor

Dhungana

Adhikari²,

Pageni³

et al. 2019

Med. J. Pokhara Acad. Health Sci.

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“…For comparison, in the group of primigravidae not taking the medicine, the active phase of labour lasts on average 331.6 min. In their research conducted on 50 women Thapa et al (2007) have also demonstrated a significant reduction of the duration of labour. The interval was found to be shorter in multigravidae (19 women).…”

Section: Discussionmentioning

confidence: 92%

Prenatal factors associated with the neonatal line thickness in human deciduous incisors

Kurek

Żądzińska

Sitek

et al. 2015

HOMO

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“…Jayashree et al [13] and Sangetaa Raman Jogi [14] compared the effects of drotaverine and valethamate bromide on the length of the active phase of labor, and they found that the length of the active phase of labor to be significantly shorter in the nulliparous women receiving drotaverine hydrochloride compared to the group receiving valethamate bromide. Thapa et al [17] found no statistically significant difference between the group receiving drotaverine and the group receiving valethamate bromide together with hyoscine N-butyl bromide in terms of the length of the first stage of labor. (p = 0.72).…”

Section: Discussionmentioning

confidence: 99%

Effect of valethamate bromide in accelerating labor: a prospective randomized controlled trial

Koçak¹,

Aldemir²,

Turğal³

et al. 2018

Clin. Exp. Obstet. Gynecol.

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Objective: This prospective randomized study aimed to investigate the effect of valethamate bromide on the length of labor. Materials and Methods: A total of 200 pregnant women, who were in the 37-41 weeks of gestation, and in the active phase of labor with cervical dilatation of 6-7 cm, were included in the study. Twenty-four pregnant women that underwent cesarean section and 33 pregnant women that required oxytocin were not included in the final statistical analysis. Finally, 71 nulliparous and 72 multiparous women were randomized to four groups according to whether they received valethamate bromide or not. Groups 1 and 2 consisted of 35 nulliparous and 37 multiparous women, respectively receiving 16 mg of valethamate bromide, whereas groups 3 and 4 consisted of 36 nulliparous and 35 multiparous women, respectively, not receiving any medication, and both groups were considered as the control group. Results: There was no statistically significant difference between the groups in terms of mean maternal age and gestational age (p > 0.05). Evaluating the groups in terms of drug side effects such as maternal tachycardia, dry mouth, flushing, headache, nausea, and vomiting, no statistically significant difference was determined between the valethamate bromide groups (groups 1 and 2) and the controls (p > 0.05). There was no statistically significant difference between the study groups (group 1 vs. 3 and groups 2 vs. 4) in terms of the time from the rupture of the membranes to the second stage of labor (p > 0.05). Contrarily, the median length of the second stage of labor was 35 (5-70) minutes and 42.5 (10-70) minutes for groups 1 and 3, respectively, in the nulliparous women and the difference between the groups was considered statistically significant (p = 0.045). For the multiparous women, the median length of the second stage of labor was 12 (5-30) minutes in group 2 and 15 (5-40) minutes in group 4 and no statistically significant difference was determined between the groups (p > 0.05). The median time from the rupture of the membranes to the delivery was 100 (10-235) minutes and 87.5 (20-395) minutes in groups 1 and 3, respectively, and 50 (25-365) minutes and 50 (10-390) minutes in groups 2 and 4, respectively. No statistically significant difference was determined between the groups (p > 0.05). Conclusion: Valethamate bromide significantly shortens the second stage of labor in nulliparous women.

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Effectiveness of drotaverine hydrochloride in progression of labour

Abstract: Aim: Aim: Aim: Aim: Aim: This study was done to compare the effectiveness of drotaverine hydrochloride and valethamate bromide in shortening duration of labour.

Cited by 8 publications

References 1 publication

A prospective study on effectiveness of drotaverine in acceleration of labor

A prospective study on effectiveness of drotaverine in acceleration of labor

Prenatal factors associated with the neonatal line thickness in human deciduous incisors

Effect of valethamate bromide in accelerating labor: a prospective randomized controlled trial

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