Brilian is a hybrid learning application that combines face-to-face learning and online learning. This study aims to analyze the effectiveness of hybrid learning of science management by using Brilian in college. This study was a pre-experiment with one group pre-test and post-test design. The sample of the study were 55 students of Information System study program, Institut Bisnis dan Informatika Stikom Surabaya, Indonesia who were divided into two groups. Before conducting hybrid learning by using Brilian, both groups of students were given a test of learning outcomes and after the learning was completed, students were given the same learning outcomes test again. The collected data was analyzed by using the Wilcoxon test; calculation of normalized gain (n-gain); and the Mann-Whitney U test. The results showed that hybrid learning of science management using Brilian is effective to improve students’ learning outcomes and is indicated by: (1) an increase in students’ learning outcomes which was that was statistically significant at α = 5%, (2) the n-gain mean was in high category, and (3) the n-gain mean was not different in the two students groups.