Effectiveness of exercise interventions in the management of cancer-related fatigue: a systematic review of systematic reviews

Zhang, Yabin; Xue-mei, Zhong; Ni, Han; Tang, Huang; Wang, Shui-Yu; Lin, Wen-Xuan

doi:10.1007/s00520-023-07619-4

Cited by 10 publications

(7 citation statements)

References 68 publications

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“…To our knowledge, this is the first overview that thoroughly describes the role that exercise plays in symptom relief for breast cancer patients undergoing adjuvant treatment. Compared to previous umbrella reviews ( 53 – 55 ), which focused mainly on the benefits of exercise in reducing fatigue in cancer patients, we focused on breast cancer patients receiving adjuvant treatment and covered a wider range of symptoms. It is well known that during adjuvant treatment, the discomfort symptoms experienced by breast cancer patients typically appear in clusters, or “symptom clusters”, which refer to the simultaneous occurrence of at least two linked symptoms defined by Professor M. J. Dodd and other academics in 2001 ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of exercise on the symptoms in breast cancer patients undergoing adjuvant treatment: an umbrella review of systematic reviews and meta-analyses

Zhao,

Tang,

Shao

et al. 2023

Front. Oncol.

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BackgroundExercise has the potential to reduce symptoms for breast cancer patients during adjuvant treatment, and high-quality systematic reviews are essential for guiding clinical practice. The objective of this umbrella review is to examine current research evidence concerning the effectiveness of exercise on symptom management in breast cancer patients undergoing adjuvant treatment.MethodsAn umbrella review was conducted. We searched for eligible systematic reviews through 11 databases until August 13rd, 2023. Two authors independently screened titles and abstracts, assessing the full-text studies based on inclusion criteria. We used AMSTAR-2 to appraise the quality of the meta-analyses. The results would be presented with narrative summaries if the replication rate of the original study for a symptom was higher than 5% (calculated via the Corrected Covered Area, CCA). The protocol was documented in the PROSPERO registry (CRD42023403990).ResultsOf the 807 systematic reviews identified, 15 met the inclusion criteria, and 7 symptoms were the main focus. The main form of exercise mentioned was aerobic combined resistance exercise. The results of the quality assessment were mostly critically low (10/15). The repetition rate calculated by CCA showed moderate to very high repetition rates (10% to 18.6%). The findings of the included reviews indicated that the effects of exercise on relieving symptoms during breast cancer adjuvant treatment were mixed.ConclusionsResearch is still needed to confirm the majority of studies’ recommendations for exercise during adjuvant treatment for breast cancer patients, as it is crucial for managing symptoms in the rehabilitation process. To increase the efficiency of exercise in symptom management, future studies may focus more on the application of bridge symptoms, symptom networks, and ecological instantaneous assessment.

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Section: Discussionmentioning

confidence: 99%

The effectiveness of exercise on the symptoms in breast cancer patients undergoing adjuvant treatment: an umbrella review of systematic reviews and meta-analyses

Zhao,

Tang,

Shao

et al. 2023

Front. Oncol.

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“…This included original research articles, systematic reviews, meta-analyses, and clinical trial results. Conversely, the team excluded articles that were not peer-reviewed, not in English, or irrelevant to MB (13). Data extraction was a critical component of the methodology.…”

Section: Methodsmentioning

confidence: 99%

Unraveling the secrets of Medulloblastoma: a comprehensive review of molecular pathways associated with pathogenesis, therapeutic resistance and potential treatment strategies

Khan,

Khalil,

Kausar

et al. 2024

JHRR

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Medulloblastoma is a highly emerging brain tumor mostly found in infants and children and is less observed in adults. Several genetic aberrations affect the normal signaling activity at an embryonal level and even after development. Various factors abrupt the normal processes which later become the hallmarks of cancer. The use of inhibitory drugs on those targets that become the site of tumor origin will help in dealing with early-stage diseases. Interactions across WNT and NOTCH signaling exhibit the ability to stimulate branching and modification of present arteries and veins in the surrounding tumor microenvironment. Cerebrospinal fluid (CSF) surrounding the primary tumor site is initially modified by tumor cells via Complement Component 3 which subsequently increases the entry of growth factors into the fluid. MB tumor cells then undergo Epithelial to Mesenchymal transition (EMT), allowing cells to disperse from the main tumor location and infiltrate CSF. The defects in DNA repair genes are potentially linked to development and response to therapy in errors within DNA repair genes that may play a role in MB progression and treatment resistance. CT and MRI scans are commonly used for the diagnosis of MB in patients. The exact mechanism behind MB is still poorly understood but certain immune and targeted therapies are applied to those pathways that provoke tumors. In the future, researchers are majorly focusing on understanding the exact mechanism so that it will help in the development of certain diagnostic and therapeutic techniques.

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“…As noted in one systematic review [65], a substantial amount of evidence supports the fact that both acute bouts of exercise, as well as regular exercise improve sleep and that these effects are preserved across adult age groups and genders. In terms of associations between energy and physical activity, while most of the research in cancer patients suggests that fatigue is reduced with regular exercise [66], findings from other studies that evaluated for changes in energy in other populations are worth noting. For example, sedentary behaviors (e.g., sitting at desks, watching television) have a stronger tendency to decrease energy than increase fatigue [67].…”

Section: Demographic and Clinical Characteristicsmentioning

confidence: 99%

Sleep disturbance and decrements in morning energy contribute to a higher symptom burden in oncology patients

et al. 2023

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Effectiveness of exercise interventions in the management of cancer-related fatigue: a systematic review of systematic reviews

Cited by 10 publications

References 68 publications

The effectiveness of exercise on the symptoms in breast cancer patients undergoing adjuvant treatment: an umbrella review of systematic reviews and meta-analyses

The effectiveness of exercise on the symptoms in breast cancer patients undergoing adjuvant treatment: an umbrella review of systematic reviews and meta-analyses

Unraveling the secrets of Medulloblastoma: a comprehensive review of molecular pathways associated with pathogenesis, therapeutic resistance and potential treatment strategies

Sleep disturbance and decrements in morning energy contribute to a higher symptom burden in oncology patients

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