Effectiveness of four doses of pertussis vaccine during infancy diminished in elementary school age: A test-negative case-control study in Japan

Ohfuji, Satoko; Okada, Kenji; Mouri, Yoko; Mihara, Yuka; Ishii, Shigeki; Miyata, Akiko; Fujino, Motoko; Motomura, Chikako; Ito, Hiroaki; Ohta, Mitsuhiro; Kasahara, Yoshihito; Nakamura, Hideo; Hasui, Masaki; Yoshikawa, Tetsushi; Tanaka, Takaaki; Nakano, Takashi; Koshida, Rie; Araki, Kazukuni; Hara, Megumi; Hirota, Yoshio

doi:10.1016/j.vaccine.2020.11.035

Cited by 6 publications

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“…Ten childhood vaccine hesitancy studies were conducted in the United States [ 23 , 44 , 45 ], Japan [ 46 , 47 ], New Zealand [ 48 ], Canada [ 49 ], Israel [ 50 ], Peru [ 51 ], and Taiwan [ 40 ], covering Asia, North America, and South America. Six, five, and two studies measured the effects of unvaccination, under-vaccination, and vaccine delay, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Meta-analysis of 18 studies [ 7 – 9 , 23 , 40 , 44 , 46 , 47 , 49 , 50 , 52 , 53 , 56 – 60 ] generated a random-effects pooled OR of 4.12 (95% CI, 3.09–5.50; p < 0.01; Table 2 ) in infants and children between the all doses vaccine-hesitant and fully vaccinated group. The cumulative meta-analysis showed a clear decreasing temporal change of pertussis OR under the effect of vaccine hesitancy (Fig.…”

Section: Resultsmentioning

confidence: 99%

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The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis

et al. 2023

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Background Robust routine immunization schedules for pertussis-containing vaccines have been applied for years, but pertussis outbreaks remain a worldwide problem. This study aimed to investigate the association between vaccine hesitancy and pertussis in infants and children. Methods We searched PubMed, Cochrane, Web of Science, Embase, and China National Knowledge Internet for studies published between January 2012 and June 2022. This study included case–control and cohort studies that assessed the association between childhood/maternal vaccine hesitancy and odds ratios (ORs), risk ratios (RRs), and vaccine effectiveness (VE) related to pertussis in infants and children $$\le$$ ≤ 9 years old. ORs/VEs with a 95% confidence interval (CI) were calculated. Random-effects meta-analysis models were used for appropriate pooled estimates, and heterogeneity was assessed using $${I}^{2}$$ I 2 . Cumulative meta-analysis and subgroup analyses stratified by study characteristics were performed. Results Twenty-two studies were included, with a mean quality score of 7.0 (range 6.0–9.0). Infants and children with pertussis were associated with higher vaccine hesitancy to all doses (OR = 4.12 [95% CI: 3.09–5.50]). The highest OR was between children who were unvaccinated over four doses and children who were fully vaccinated (OR = 14.26 [95%CI: 7.62–26.70]); childhood vaccine delay was not statistically significantly associated with pertussis risk (OR = 1.18 [95% CI: 0.74–1.89]). Maternal vaccine hesitancy was associated with significantly higher pertussis risk in infants aged 2 and 3 months old, with higher pertussis ORs in infants $$\le$$ ≤ 2 months old (OR = 6.02 [95%CI: 4.31–8.50], OR = 5.14 [95%CI: 1.95–13.52] for infants $$\le$$ ≤ 2 and $$\le$$ ≤ 3 months old, respectively). Maternal and childhood VEs were high in reducing pertussis infection in infants and children. The administration time of maternal vaccination had little effect on VE. Conclusion Vaccine hesitancy increased pertussis risks in infants and children. Ensuring that children receive up-to-date pertussis vaccines is essential; short delays in receiving childhood vaccinations may be unimportant. Maternal vaccinations for pertussis should be encouraged.

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