Background Acute diarrhea is described as the acute onset of three or more loose or watery stools a day lasting for 14 days or less. The study aimed to evaluate the effect of educational program on nurses' performance regarding intensive care units induced diarrhea among critically ill patient. Design: A quasi-experimental design was utilized in this study. Subjects and method A convenience sampling of ( 50) nurses participated in the study. The study was conducted at the Medical Intensive Care Unit and Cardio Care Unit of El-Menshawy General Hospital affiliated to Ministry of Health. Tools of the study were used for data collection Tool (I) Structural Interviewing Questionnaire. Tool (II) observational checklist regarding nurses' practice. Results The main results revealed that there was statistical significant improvement in total knowledge and practical level among studied nurses post implementation of educational program at p<0.05 about induced diarrhea in intensive care units. Conclusion The implementation of educational programme had positive effect on nurses' knowledge and practice regarding intensive care units induced diarrhea among critically ill patient. Recommendation It recommended that ongoing learning protocol of care must be designed regarding proper hygienic care, perineal care, and skin care during induced diarrhea and implemented for nurses at ICU& CCU for the importance of maintaining checkup.