Objective. To determine pharmacy student reactions to and experiences with an intervention based upon the principle of salience to reduce psychological attraction and attention to smartphones. Method. For a period of 3 weeks, participants were directed to change their smartphone's color setting to grayscale mode, turn off social media notifications, remove social media icons from smartphone home screen, and place the device away from bed when sleeping. A thematic analysis was performed on responses to an anonymous, open-ended survey question that asked participants to record any positive/negative changes to their life and well-being as a result of participating in the study. Results. Thematic analysis revealed twenty unique themes, which provided a variety of notable observations including a reduction in both smartphone and social media use, reduced allure because of grayscale mode, frustrations caused by grayscale mode, increased productivity, and general improvements in sleep, face-to-face interactions, and overall wellbeing Conclusion. Results of this study provide initial evidence that changes to smartphone settings and physical placement at night may lead to positive outcomes. Participants reported primarily positive effects regarding well-being and reduced smartphone usage as a result of participating in the study. In many cases, less time on smartphones meant improved sleep, more productivity, more time for social/leisure activities, improved face-to-face interactions, and/or improvement in wellbeing.