Medical abortion in the first and second trimesters of pregnancy offers women a safe and effective alternative to surgical termination. The World Health Organization supports a combination of mifepristone and misoprostol as the optimal regimen in both the first and second trimesters of pregnancy, but doses, routes, and timing of administration vary with gestational age. Most methods of contraception can be initiated at the time of medical abortion in women wishing to delay fertility, with the exception of the intrauterine device, which can be initiated as soon as a woman is no longer pregnant.