Effectiveness of metoclopramide in preventing the incidence of post-operative nausea and vomiting in lower-segment caesarean section

Background : Caesarean section is one of the most prevalent surgical procedures among women. Pain, nausea and vomiting are the most common adverse effects of surgery, which are reported in more than 66% of patients undergoing caesarean section under spinal anesthesia Methods: A Hospital based, Prospective, Randomized, Double-Blind Interventional study was conducted in the Department of Anaesthesiology and Critical Care, at Zanana hospital and Mahila Chikitsalya, SMS Medical College, Jaipur. after obtaining the permission from the institutional ethics committee and after obtaining written informed consent in 84 patients aged above 18 years belonging to ASA grade 1 and 2 scheduled to undergo elective LSCS under spinal anaesthesia. Results: Incidence of nausea was signicantly more in group B than groups Afrom 1 hrs starting, incidence of vomiting decreased in group-Athan group-B, incidence of retching was signicantly more in group B than groups Aat 2 hrs. Conclusion: Ondansetron (4 mg=2 ml) dose was better than metoclopramide (4 mg=2 ml) in patients undergoing caesarean section under spinal anesthesia

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A Comparative Study of Metoclopramide Versus Ondansetron for Postoperative Nauseaand Vomiting (Ponv) in Elective Lower Segment Caesarean Section Under Spinalanaesthesia

Sharma

Jatav

2022

ijsr

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Preoperative Ondansetron Versus Metoclopramide for Prevention of Nauseaand Vomiting in Elective Lower Segment Caesarean Section (Lscs) Under Spinalanaesthesia

Kothari

Priyal

2021

ijsr

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INTRODUCTION: Post Operative Nausea and Vomiting (PONV) are the most common distressing symptom after LSCS. Antiemetic drugs play an important role to prevent it. Though many drugs have been tried as prophylaxis and treatment of PONV, no drug has been proved signicantly effective and hence, the present study was undertaken to compare the efcacy and safety of IVmetoclopramide and IVOndansetron as prophylaxis for postoperative nausea and vomiting in LSCS under spinal Anaesthesia OBJECTIVES: To study comparison of IV Ondansetron and IV Metoclopramide for prevention of postoperative nausea and vomiting as well as to compare any adverse effect occurrence through drugs in elective LSCS under spinal Anaesthesia. METHODS: It was a prospective study in which 100 patients were selected and randomly allotted into 2 groups, 50 patients in each group, according to inclusion criteria. Group A: Inj. Ondansetron 0.15 mg/kg i.v. Group B: Inj. Metoclopramide 0.25 mg/kg i.v. RESULT: Mean Age, Weight and Duration of surgery are comparable in both the groups without any statistical signicant difference. Incidence of nausea was 12% in group B and there was no incidence of nausea in group A in 30 min after injecting drugs. The incidence of nausea was 14% in group Aand 28% in group B in 45 min after injecting drugs. Incidence of vomiting was 16% in group B and there was no incidence of vomiting in group Ain 30 min after injecting drugs. The incidence of vomiting was 8% in group Aand 22% in group B in 45 min after injecting drugs CONCLUSION: Efcacy and safety of ondansetron is more than metoclopramide for prevention of nausea and vomiting in LSCS under spinal Anaesthesia

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Effectiveness of metoclopramide in preventing the incidence of post-operative nausea and vomiting in lower-segment caesarean section

Cited by 2 publications

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A Comparative Study of Metoclopramide Versus Ondansetron for Postoperative Nauseaand Vomiting (Ponv) in Elective Lower Segment Caesarean Section Under Spinalanaesthesia

A Comparative Study of Metoclopramide Versus Ondansetron for Postoperative Nauseaand Vomiting (Ponv) in Elective Lower Segment Caesarean Section Under Spinalanaesthesia

Preoperative Ondansetron Versus Metoclopramide for Prevention of Nauseaand Vomiting in Elective Lower Segment Caesarean Section (Lscs) Under Spinalanaesthesia

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