Effectiveness of Nanomaterial Copper Cold Spray Surfaces on Inactivation of Influenza A Virus

Sundberg, Kristin; Champagne,

doi:10.4172/2155-952x.1000205

Cited by 12 publications

(4 citation statements)

References 2 publications

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“… 34 , 35 The antiviral activity of copper nanoparticles (CuNPs) is mainly a contact mechanism through metal ion binding, which is especially effective on the enveloped virus. 36 , 37 To date, the effectiveness of AgNPs and CuNPs against SARS-CoV is widely recognized and has been proposed for medicinal applications. 38 , 39 Much recent progress has been achieved on the surface of stainless steel using Ag coatings and on facial masks using Cu compounds and copper–silver (Cu–Ag) nanohybrids against SARS-CoV-2.…”

mentioning

confidence: 99%

“…Similarly, copper destroys the replication and propagation abilities of SARS-CoV, influenza virus, HIV, and fungi after a short period of exposure . Copper has long been regarded as a safe antiviral reagent as it is one of the useful nutrients required for normal functioning of the human body and is also an effective and low-cost complementary strategy to help reduce the transmission of several infectious diseases by limiting transmission of nosocomial infections. , The antiviral activity of copper nanoparticles (CuNPs) is mainly a contact mechanism through metal ion binding, which is especially effective on the enveloped virus. , To date, the effectiveness of AgNPs and CuNPs against SARS-CoV is widely recognized and has been proposed for medicinal applications. , Much recent progress has been achieved on the surface of stainless steel using Ag coatings and on facial masks using Cu compounds and copper–silver (Cu–Ag) nanohybrids against SARS-CoV-2. − However, demonstration and use of NPs as antiviral coatings on plastic surfaces remains rare. There are three major strategies to achieve antimicrobial polymers, namely, (a) incorporate antimicrobial agents directly into polymers during plastic processing, (b) coat or immobilize antimicrobials onto polymer surfaces, and (c) use polymers that are inherently antimicrobial .…”

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confidence: 99%

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Enhancement of Antiviral Effect of Plastic Film against SARS-CoV-2: Combining Nanomaterials and Nanopatterns with Scalability for Mass Manufacturing

et al. 2021

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Direct contact with contaminated surfaces in frequently accessed areas is a confirmed transmission mode of SARS-CoV-2. To address this challenge, we have developed novel plastic films with enhanced effectiveness for deactivating the SARS-CoV-2 by means of nanomaterials combined with nanopatterns. Results prove that these functionalized films are able to deactivate SARS-CoV-2 by up to 2 orders of magnitude within the first hour compared to untreated films, thus reducing the likelihood of transmission. Nanopatterns can enhance the antiviral effectiveness by increasing the contact area between nanoparticles and virus. Significantly, the established process also considers the issue of scalability for mass manufacturing. A low-cost process for nanostructured antiviral films integrating ultrasonic atomization spray coating and thermal nanoimprinting lithography is proposed. A further in-depth investigation should consider the size, spacing, and shape of nanopillars, the type and concentration of nanoparticles, and the scale-up and integration of these processes with manufacturing for optimal antiviral effectiveness.

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confidence: 99%

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confidence: 99%

Enhancement of Antiviral Effect of Plastic Film against SARS-CoV-2: Combining Nanomaterials and Nanopatterns with Scalability for Mass Manufacturing

et al. 2021

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“…The bacterial measurements were taken after 2 h of continuous exposure to the surfaces. The viral measurements were taken after several intermediate exposures up to 2 h. The full details of the procedures are given in reference [19,20]. Figure 4 shows the percent of surviving S. aureus after 2 h of surface exposure.…”

Section: Microbiological Proceduresmentioning

confidence: 99%

Kinetically Deposited Copper Antimicrobial Surfaces

2019

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Bacterial and viral contamination of contact surfaces increases the risk of infection. A great deal of work has been done on the capabilities of copper and its alloys to protect against a variety of microorganisms endangering public health, particularly in healthcare and food processing applications. This work has conclusively shown the effectiveness of copper for touch surface disinfection; however, the optimum microstructural characteristics of the copper surface have not been established. The sterilization effectiveness of three kinetically sprayed copper surfaces and two copper feedstocks were examined. The surfaces were inoculated with methicillin-resistant Staphylococcus aureus (MRSA) and influenza A virus. After a two-hour exposure to the surfaces, the surviving microorganisms were assayed, and the results contrasted. These tests showed substantial antimicrobial differences between the coatings generated by the spray techniques and those obtained by different feedstock powders. The significance of the copper spray application was demonstrated, and the application-dependent mechanism for antimicrobial effectiveness was explained.

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“…The effectiveness of copper as a broad antimicrobial (bacteria, fungi, and viruses) agent has been known since ancient times [13]. Recently, Longano et al [14] observed the antibacterial activity of laser-generated copper nanoparticles and Sundberg et al [15] explored the antiviral performance of an aluminum substrate covered in copper nanoparticles. Furthermore, Doremalen et al [16] and Warnes et al [17] successfully identified the anti-coronavirus properties of copper and its alloys.…”

Section: Introductionmentioning

confidence: 99%

In Situ Collection of Nanoparticles during Femtosecond Laser Machining in Air

Joy

Kietzig

2021

Nanomaterials

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Nanoparticles generated during laser material processing are often seen as annoying side products, yet they might find useful application upon proper collection. We present a parametric study to identify the dominant factors in nanoparticle removal and collection with the goal of establishing an in situ removal method during femtosecond laser machining. Several target materials of different electrical resistivity, such as Cu, Ti, and Si were laser machined at a relatively high laser fluence. Machining was performed under three different charge conditions, i.e., machining without an externally applied charge (alike atmospheric pulsed laser deposition (PLD)) was compared to machining with a floating potential and with an applied field. Thereby, we investigated the influence of three different charge conditions on the behavior of laser-generated nanoparticles, in particular considering plume deflection, nanoparticle accumulation on a collector plate and their redeposition onto the target. We found that both strategies, machining under a floating potential or under an applied field, were effective for collecting laser-generated nanoparticles. The applied field condition led to the strongest confinement of the nanoparticle plume and tightest resulting nanoparticle collection pattern. Raster-scanning direction was found to influence the nanoparticle collection pattern and ablation depth. However, the laser-processed target surface remained unaffected by the chosen nanoparticle collection strategy. We conclude that machining under a floating potential or an applied field is a promising setup for removing and collecting nanoparticles during the machining process, and thus provides an outlook to circular waste-free laser process design.

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Effectiveness of Nanomaterial Copper Cold Spray Surfaces on Inactivation of Influenza A Virus

Cited by 12 publications

References 2 publications

Enhancement of Antiviral Effect of Plastic Film against SARS-CoV-2: Combining Nanomaterials and Nanopatterns with Scalability for Mass Manufacturing

Enhancement of Antiviral Effect of Plastic Film against SARS-CoV-2: Combining Nanomaterials and Nanopatterns with Scalability for Mass Manufacturing

Kinetically Deposited Copper Antimicrobial Surfaces

In Situ Collection of Nanoparticles during Femtosecond Laser Machining in Air

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