Effectiveness of niacin supplementation for patients with type 2 diabetes

Xiang, Dan; Zhang, Qian; Wang, Yangtian

doi:10.1097/md.0000000000021235

Cited by 19 publications

(16 citation statements)

References 40 publications

(31 reference statements)

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“…In recent years, it has been reported in anti-obesity studies that melatonin or niacin applications limit obesity and regulate physiological and metabolic damage due to obesity (Preuss et al, 2004;Cantó et al, 2012;Mostafavi et al, 2017;Heo et al, 2018;Yin et al, 2018;Ye et al, 2019;Xiang et al, 2020;Mendes et al, 2021). However, there is no study evaluating and comparing niacin and melatonin administration on anti-obesity.…”

Section: Discussionmentioning

confidence: 99%

“…They concluded that this supplement increased cellular NAD + levels in skeletal muscle and brown adipose tissue and prevented weight gain and obesity induced by a high-fat diet. In addition, Xiang et al (2020) concluded that niacin supplementation could improve lipid profiles for patients with T2DM without affecting glycemic levels (Xiang et al, 2020). In addition, Preuss et al (2004) state that the combination of niacin-bound chromium can be used as a safe weight loss formula (Preuss et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Keski̇n

Acı²,

Duran

et al. 2021

Caucasian Journal of Science

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Son yıllarda dünyada obezitenin artması obezite ile mücadelede yeni stratejilerin geliştirilmesine yol açmıştır. Bu çalışmada, model organizma olarak ratlarda obezite ile mücadelede niasin ve melatonin takviyelerinin etkisinin araştırılması amaçlanmıştır. Ratlara 10 gün süreyle niasin ve melatonin takviyesi yapıldıktan sonra koşu bandı egzersizi yapıldı. Her grupta 10 günlük egzersiz sonunda kilo kaybı gözlendi. Bu çalışmada, koşu bandı egzersizi yapan ratlarda kontrol grubuna göre niasin takviyesinin kilo kaybına yol açtığı gözlendi. Ayrıca melatonin+niasin takviyesinde gözlenen kilo kaybının sadece niasin takviyesine göre daha yüksek olduğu bulunmuştur. Sonuç olarak obezite ile mücadele için egzersiz öncesi niasin ve melatonin takviyesi önerilebilir.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Keski̇n

Acı²,

Duran

et al. 2021

Caucasian Journal of Science

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“…Alternatively, data reviewed from 8 randomized controlled trials showed that the NA supplementation improved the blood lipid profile, however, did not affect plasma glucose and hemoglobin A1c levels in Type 2 diabetic patients. 14 Nevertheless, a recent study provided a negative result of NR effects on lifespan in both male and female mice at the doses tested. 15 …”

Section: Nad + In Healthy Agingmentioning

confidence: 99%

NAD⁺, Senolytics, or Pyruvate for Healthy Aging?

Zhou

2021

Nutr Metab Insights

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In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD+) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD+ precursors was first demonstrated with its new role in DNA damage repairing in mice, restoring old mice to their physical state at young ones. The finding encourages extensive studies in animal models and patients. NAD+ and its precursors have been popular products in nutrition markets. Alternatively, it was also evidenced that clearance of cellular senescence by senolytics preserved multiorgan (kidney and heart) function and extended healthy lifespan in mice. Subsequent studies confirmed findings in elderly patients subjected with idiopathic pulmonary fibrosis. The senolytic therapy is now focused on various diseases in animal and clinical studies. However, pyruvate, as both a NAD+ substitute and a new senolytic, may be advantageous, on the equimolar basis, over current products above in preventing and treating diseases and aging. Pyruvate-enriched fluids, particularly pyruvate oral rehydration salt, may be a novel intervention for diseases and aging besides critical care. Albeit the direct evidence that benefits healthy aging is still limited to date, pyruvate, as both NAD+ provider and senolytic agent, warrants intensive research to compare NAD+ or senolytics for healthy aging, specifically on the equimolar basis, in effective blood levels. This review briefly discussed the recognition of healthy aging by comparing NAD+ and Senolytics with sodium pyruvate from the clinical point of view.

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“…The effects on insulin release from islet β-cells have been extensively investigated in T2D with secondary failure of sulfonylureas, where niacin at the daily dose of 1.5 g significantly restored C-peptide release [ 108 ]. However, a meta-analysis of eight trials where niacin was used to treat hyperlipidemia in 2110 T2D patients showed no significant effects on plasma glucose (weighted mean difference (WMD), 0.18 mmol/L; 95% CI, −0.14 to 0.50) and HbA1c levels (WMD, 0.39%; 95% CI, −0.15 to 0.94) [ 109 ]. Niacin appeared to cause a deterioration of glucose control, in keeping with data observed in a meta-analysis of 11 trials in patients without diabetes at entry, where niacin was used to treat dyslipidaemia and prevent cardiovascular events [ 110 ] (relative risk of de novo T2D: 1.34 (95% CI 1.21–1.49)).…”

Section: Nutritional Supplements For Metabolic Controlmentioning

confidence: 99%

Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges

et al. 2021

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Unhealthy behaviours, including diet and physical activity, coupled with genetic predisposition, drive type 2 diabetes (T2D) occurrence and severity; the present review aims to summarise the most recent nutritional approaches in T2D, outlining unmet needs. Guidelines consistently suggest reducing energy intake to counteract the obesity epidemic, frequently resulting in sarcopenic obesity, a condition associated with poorer metabolic control and cardiovascular disease. Various dietary approaches have been proposed with largely similar results, with a preference for the Mediterranean diet and the best practice being the diet that patients feel confident of maintaining in the long term based on individual preferences. Patient adherence is indeed the pivotal factor for weight loss and long-term maintenance, requiring intensive lifestyle intervention. The consumption of nutritional supplements continues to increase even if international societies do not support their systematic use. Inositols and vitamin D supplementation, as well as micronutrients (zinc, chromium, magnesium) and pre/probiotics, result in modest improvement in insulin sensitivity, but their use is not systematically suggested. To reach the desired goals, patients should be actively involved in the collaborative development of a personalised meal plan associated with habitual physical activity, aiming at normal body weight and metabolic control.

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Effectiveness of niacin supplementation for patients with type 2 diabetes

Abstract: Supplemental Digital Content is available in the text

Cited by 19 publications

References 40 publications

Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

NAD⁺, Senolytics, or Pyruvate for Healthy Aging?

Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges

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Effectiveness of niacin supplementation for patients with type 2 diabetes

Abstract: Supplemental Digital Content is available in the text

Cited by 19 publications

References 40 publications

Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models

NAD+, Senolytics, or Pyruvate for Healthy Aging?

Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges

Contact Info

Product

Resources

About

NAD⁺, Senolytics, or Pyruvate for Healthy Aging?