Effectiveness of Oral Magnesium in a Patient With Ventricular Tachycardia Due to Hypomagnesemia

Tsuji, Akiko; Araki, Kiyoshi; Maeyama, Katsuhiro; Hashimoto, Keitaro

doi:10.1177/107424840501000309

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…While the cardiac evaluation for arrhythmia was normal, the Mg 2+ serum level was low. Oral supplementation with magnesium effectively suppressed both PVCs and the episodes of ventricular tachycardia, documented over a follow-up of 5 years [ 82 ].…”

Section: Cardiovascular Importance Of Magnesiummentioning

confidence: 99%

The Role of Hypomagnesemia in Cardiac Arrhythmias: A Clinical Perspective

Negru

Pastorcici²,

Crişan

et al. 2022

Biomedicines

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The importance of magnesium (Mg2+), a micronutrient implicated in maintaining and establishing a normal heart rhythm, is still controversial. It is known that magnesium is the cofactor of 600 and the activator of another 200 enzymatic reactions in the human organism. Hypomagnesemia can be linked to many factors, causing disturbances in energy metabolism, ion channel exchanges, action potential alteration and myocardial cell instability, all mostly leading to ventricular arrhythmia. This review article focuses on identifying evidence-based implications of Mg2+ in cardiac arrhythmias. The main identified benefits of magnesemia correction are linked to controlling ventricular response in atrial fibrillation, decreasing the recurrence of ventricular ectopies and stopping episodes of the particular form of ventricular arrhythmia called torsade de pointes. Magnesium has also been described to have beneficial effects on the incidence of polymorphic ventricular tachycardia and supraventricular tachycardia. The implication of hypomagnesemia in the genesis of atrial fibrillation is well established; however, even if magnesium supplementation for rhythm control, cardioversion facility or cardioversion success/recurrence of AF after cardiac surgery and rate control during AF showed some benefit, it remains controversial. Although small randomised clinical trials showed a reduction in mortality when magnesium was administered to patients with acute myocardial infarction, the large randomised clinical trials failed to show any benefit of the administration of intravenous magnesium over placebo.

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Section: Cardiovascular Importance Of Magnesiummentioning

confidence: 99%

The Role of Hypomagnesemia in Cardiac Arrhythmias: A Clinical Perspective

Negru

Pastorcici²,

Crişan

et al. 2022

Biomedicines

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“…2+ are used for the treatment of digitalis intoxication, vasospastic angina pectoris, and arrhythmias. Correction of Mg 2+ deficiency (MD) eliminates rhythm disturbances in parenteral and/or peroral administration of Mg 2+ salts.The effect of various Mg 2+ compounds such as Mg(OH) 2 , MgO, MgSO 4 was evaluated in numerous experimental and clinical studies [4,7,8]. Holter monitoring showed that the incidence of ventricular and atrial arrhythmias in individuals with low blood Mg 2+ content caused by insufficient alimentary Mg 2+ intake is higher than in the group with normal Mg 2+ content [6].…”

mentioning

confidence: 99%

Arrhythmogenic threshold of the myocardium under conditions of magnesium deficiency

et al. 2008

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We studied the arrhythmogenic threshold of the myocardium after injection of CaCl2 to magnesium-deficient rats receiving Mg2+ L-aspartate, MgCl2, their combination with vitamin B6, and reference preparations Magne B6 and MgSO4 until complete compensation of magnesium level in the plasma and erythrocytes. Magnesium-deficient diet and deionized water were used for inducing alimentary Mg2+ deficiency and modeling pathological changes in rats. After reducing Mg2+ level to 0.7 mmol/liter in the plasma and to 1.5 mmol/liter in erythrocytes, Mg L-aspartate, MgCl2, their combination with vitamin B6, as well as Mg2+ deficiency led to a decrease in the dose of CaCl2 provoking heart rhythm disturbances in 50% animals and shortening of animal life span. Administration of the test magnesium salts increased the arrhythmogenic threshold; Mg2+ salts were comparable by their efficiency with Magne B6 and were far superior to MgSO4.

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