Effectiveness of Shin'i-Seihai-To for Sinusitis with Polyp.

Kato, Masashi; Hattori, Taku; Beppu, Reiko; Kitamura, Mayumi; Yanagita, Noriyuki

doi:10.5631/jibirin.87.561

Cited by 6 publications

(6 citation statements)

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“…The levels of each parameter in nasal lavage fluids were compared after they were multiplied by the dilution factor Ureaserum(mg/dL)/Ureanasal(mg/dL) and revised to the levels in ELF. Collection of nasal lavage was by the technique described by Kato et al 3 The scores of subjective symptoms (nasal blockage, secretion, and sneezing) were estimated by the method of Kato et al 14 · 15 (The highest score is 9 points. )…”

Section: Methodsmentioning

confidence: 99%

Evidence of Potential Regulation by Interleukin-4 of the Soluble Intercellular Adhesion Molecule 1 Level in Patients with Seasonal Allergic Rhinitis under Provocation by a Small Amount of Natural Allergen

Kato¹,

Hattori²,

Liu³

et al. 1998

Ann Otol Rhinol Laryngol

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Interleukin-4 (IL-4) and intercellular adhesion molecule 1 (ICAM-1) are assumed to be involved in the pathogenesis of allergic disease. In this study, we examined the potential link between IL-4 and soluble ICAM-1 (sICAM-1) levels in patients with allergic rhinitis. The levels of sICAM-1 and IL-4 in sera and in nasal epithelial lining fluids (ELF) from 12 patients with Japanese cedar pollinosis were measured preseason through postseason, and the results were compared with those from 7 healthy subjects. In sera from the allergic subjects, the levels of sICAM- 1 were upregulated during the early part of the season and downregulated during the middle of the season, with upregulation of the IL-4 levels. Moreover, a negative correlation was found between the serum sICAM-1 levels and serum IL-4 levels during the middle (r = -.80) and late (r = -.73) parts of the season. In ELF from allergic subjects, the levels of sICAM-1 were significantly upregulated during the early and middle parts of the season, and began to be downregulated during the late part of the season, with upregulation of the levels of IL-4. In conclusion, IL-4 possibly acts as a potential suppressor of sICAM-1 in the pathogenesis of seasonal allergic rhinitis, at least under provocation by a small amount of natural allergen.

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Section: Methodsmentioning

confidence: 99%

Evidence of Potential Regulation by Interleukin-4 of the Soluble Intercellular Adhesion Molecule 1 Level in Patients with Seasonal Allergic Rhinitis under Provocation by a Small Amount of Natural Allergen

Kato¹,

Hattori²,

Liu³

et al. 1998

Ann Otol Rhinol Laryngol

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“…Shin'iseihaito (xinyiqingfeitang) is a formula of traditional Japanese Kampo medicine and traditional Chinese medicine both of which are originated from ancient Chinese medicine, which is used for the treatment of upper respiratory tract disease, especially sinusitis [ 14 , 15 ]. In our previous studies, we investigated the antimicrobial effect of Shin'iseihaito extract (SSHT) in a pneumococcus-infected model [ 16 ], the antibacterial activity of SSHT extract against S. pneumoniae in vitro [ 17 ], and the preventive effect of SSHT in an ovalbumin-induced allergic rhinitis model [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Shin’iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of Streptococcus pneumoniae In Vitro

Minami

Konishi

Takase

et al. 2017

BioMed Research International

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Streptococcus pneumoniae (S. pneumoniae) is the important pathogen that causes otolaryngeal diseases such as sinusitis. S. pneumoniae frequently forms the biofilm to prevent severe circumstances such as antimicrobial agents. Shin'iseihaito (xinyiqingfeitang) is a formula of Japanese traditional Kampo medicine that has 9 crude drugs and provides the medicinal usage for sinusitis. The objective of the present study is to reveal the mechanism of antibiofilm activity by Shin'iseihaito extract (SSHT). SSHT significantly inhibited the formation of biofilm from S. pneumoniae ATCC 49619 in dose- and time-dependent manners. SSHT also significantly suppressed the biofilm formation by other five different cps types of S. pneumoniae clinical isolates. We found that the extracts of 8 out of 9 components in Shin'iseihaito had the inhibitory effects of biofilm formation, and the extract of the root of Scutellaria baicalensis had the strongest effect among the ingredients of Shin'iseihaito. We found that the capsule of SSHT-treated S. pneumoniae was significantly thinner than that of the untreated group and that SSHT reduced the hydrophobicity of bacterial cell surface. Our results suggest that Shin'iseihaito may be a useful agent for the treatment of S. pneumoniae-induced sinusitis because of the inhibition of biofilm formation of S. pneumoniae.

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“…In Japan, Kampo medicine, which had been developed from ancient Chinese medicine, is recognized as an effective alternative medicine against several diseases [ 8 , 9 ]. Shin'iseihaito (Xinyiqingfeitang) is a formula in both traditional Japanese Kampo medicine and Chinese medicine, which is used for the treatment of upper respiratory tract diseases, especially sinusitis, in Japan [ 10 , 11 ]. In Taiwan, the clinical investigation of the characteristics of adjunctive traditional Chinese medicine use in patients with chronic rhinosinusitis demonstrated that the most common Chinese herbal formula used was Xinyiqingfeitang [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Shin’iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation

Minami

Konishi

Takase

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Streptococcus pneumoniae (S. pneumoniae) causes sinusitis. The general treatment of S. pneumonia sinusitis is by using antibiotics; however, one of their serious problems is the attenuation of their effect. Shin'iseihaito (Xinyiqingfeitang), a formula of Japanese traditional Kampo medicine, has been used for the treatment of sinusitis in Japan. In this study, we investigated the efficacy of Shin'iseihaito against S. pneumoniae-caused sinusitis in mice. Oral administration of Shin'iseihaito extract (SSHT) decreased the nasal colonization of S. pneumoniae in both prophylactic and therapeutic treatments, respectively, and the former was more effective than the latter. Histopathological analysis revealed that the epithelial tissue from S. pneumoniae-infected nose under SSHT treatment recovered the tissue destruction in comparison to infected nose. We also confirmed this result by scanning electron microscopic analysis. Murine peritoneal macrophages from SSHT-treated mice had significant phagocytic activity in comparison to those from untreated group. We also found that tumor necrosis factor-α, interleukin-1β, interleukin-6, and monocyte chemotactic protein-1 levels and the migration of macrophages from S. pneumoniae-infected mice with the treatment with SSHT were increased compared to those from untreated group. Our data suggest that Shin'iseihaito may be useful for the treatment of S. pneumoniae-induced sinusitis.

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Effectiveness of Shin'i-Seihai-To for Sinusitis with Polyp.

Cited by 6 publications

References 0 publications

Evidence of Potential Regulation by Interleukin-4 of the Soluble Intercellular Adhesion Molecule 1 Level in Patients with Seasonal Allergic Rhinitis under Provocation by a Small Amount of Natural Allergen

Evidence of Potential Regulation by Interleukin-4 of the Soluble Intercellular Adhesion Molecule 1 Level in Patients with Seasonal Allergic Rhinitis under Provocation by a Small Amount of Natural Allergen

Shin’iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of Streptococcus pneumoniae In Vitro

Effect of Shin’iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation

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