Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye

Johnson, Michael E.; Murphy, Paul J.; Boulton, Michael E.

doi:10.1007/s00417-005-0028-1

Cited by 144 publications

(123 citation statements)

References 9 publications

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“…It is likely Clinitas Soothe was preferred by more participants than Hyabak due to the higher concentration of sodium hyaluronate contained in Clinitas Soothe (0.4%) when compared to Hyabak (0.15%), as found previously [2].…”

Section: Discussionsupporting

confidence: 69%

“…Sodium hyaluronate increases tear film stability by increasing tear film viscosity between blinks [2]. Clinical trials of sodium hyaluronate dry eye treatment have reported an increase in ocular comfort [1][2][3][4]15], a reduction in NaFl corneal staining [3], a reduction in Rose Bengal staining [28], an increase in NITBUT [2,4], an increase in Schirmer's score [29] and an improvement in impression cytology grading [16]. Sodium hyaluronate is a naturally occurring glycosaminoglycan of the extracellular matrix and a ligand for the hyaluronate receptor CD44 [30].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous compositions of dry eye treatments are commercially available, principally differing in which element of the tear film they primarily aim to replace. Sodium hyaluronate is a glycosaminoglycan with viscoelastic properties 2 that increases tear film stability [2][3][4] and increases epithelial cell migration [5][6]. Carboxymethylcellulose (CMC) is an anionic cellulose polymer with a carboxylic group, which exhibits a high affinity for bioadhesion [7], increases tear film stability 3 and increases epithelial cell migration [8].…”

Section: Introductionmentioning

confidence: 99%

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Can the optimum artificial tear treatment for dry eye disease be predicted from presenting signs and symptoms?

Essa¹,

Laughton

Wolffsohn

2018

Contact Lens and Anterior Eye

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PurposeTo assess dry eye treatment with four preservative-free dry eye artificial tear treatments to facilitate evidence-based prescribing. Methods ResultsThe impact of each dry eye treatment on ocular signs and symptoms was similar, however OSDI (p=0.002), LIPCOF (p=0.014) and conjunctival staining (p<0.001) significantly improved from baseline. Clinitas Soothe and Hyabak were preferred by 34%/30% of participants, but only subjective comparison with the other drops influenced this choice. TheraTears was preferred (by 24%) by those with a lower baseline tear volume (p=0.01) and Tears Again (by 12%) by those with a thinner baseline lipid layer (p=0.04). The treatment that afforded the greatest improvement in clinical signs did not consistently match each individual's preferred treatment. ConclusionsIf prescribed to a general dry eye population, the artificial tears performed similarly, improving symptoms and conjunctival signs. However, osmolarity balanced artificial tears were the preferred treatment in individuals with low baseline tear volume and lipisomal spray for individuals with a baseline lipid layer deficiency. Key wordsDry eye; carboxymethylcellulose; liposomal spray; sodium hyaluronate; randomised control trial; artificial tears Highlights• In a general dry eye population, the artificial tears tested performed similarly• Treatment effects still evident after 4 months of treatment• Artificial tears provide more than transient relief to symptoms• Artificial tears aid in breaking the vicious dry eye disease cycle• Osmolarity balanced drops preferred by those with low baseline tear volume• Lipisomal spray preferred treatment by those with baseline lipid layer deficiency

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Can the optimum artificial tear treatment for dry eye disease be predicted from presenting signs and symptoms?

Essa¹,

Laughton

Wolffsohn

2018

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

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“…Many studies have proved the safety and the efficacy of native HA solutions as artificial tears [222,[224][225][226]. More recently, also novel derivatives of hyaluronan with improved mechanical and biological properties are being investigated to formulate eye drops with enhanced ocular residence times.…”

Section: Ophthalmologic Surgery and Ophthalmologymentioning

confidence: 99%

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

Fallacara¹,

Baldini²,

Manfredini³

et al. 2018

Preprint

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Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitary in humans and in other vertebrates. HA is involved in many key processes -including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology-, and has unique physico-chemical properties -such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetic. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties, and biology -occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors. Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products which currently are on the market or are undergoing further investigations.

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“…21,22 HA is used as a tear substitute for dry eyes to increase tear film stability and reduce subjective symptoms, such as ocular irritation and burning. [23][24][25] Thus, HA is a remarkable biopolymer that appears to have an impressive array of biological functions.…”

Section: Introductionmentioning

confidence: 99%

High molecular weight hyaluronan decreases oxidative DNA damage induced by EDTA in human corneal epithelial cells

et al. 2012

Eye

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Purpose To investigate the toxic effects of ethylenediaminetetraacetic acid disodium salt (EDTA), a corneal penetration enhancer in topical ophthalmic formulations, on DNA in human corneal epithelial cells (HCEs), and to investigate whether the effect induced by EDTA can be inhibited by high molecular weight hyaluronan (HA). Methods Cells were exposed to EDTA in concentrations ranging from 0.00001 to 0.01% for 60 min, or 30 min high molecular weight HA pretreatment followed by EDTA treatment. The cell viability was measured by the MTT test. Cell apoptosis was determined with annexin V staining by flow cytometry. The DNA single-and double-strand breaks of HCEs were examined by alkaline comet assay and by immunofluorescence microscope detection of the phosphorylated form of histone variant H2AX (gH2AX) foci, respectively. Reactive oxygen species (ROS) production was assessed by the fluorescent probe, 2 0 ,Results EDTA exhibited no adverse effect on cell viability and did not induce cell apoptosis in human corneal epithelial cells at concentrations lower than 0.01%. However, a significant increase of DNA single-and double-strand breaks was observed in a dose-dependent manner with all the concentrations of EDTA tested in HCEs. In addition, EDTA treatment led to elevated ROS generation. Moreover, 30 min preincubation with high molecular weight HA significantly decreased EDTA-induced ROS generation and DNA damage. Conclusions EDTA could induce DNA damage in HCEs, probably through oxidative stress. Furthermore, high molecular weight HA was an effective protective agent that had antioxidant properties and decreased DNA damage induced by EDTA.

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Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye

Abstract: Sodium hyaluronate of 0.1% and 0.3% reduces symptoms of ocular irritation and lengthens NIBUT in subjects with moderate dry eye more effectively than saline, in terms of peak effect and duration of action.

Cited by 144 publications

References 9 publications

Can the optimum artificial tear treatment for dry eye disease be predicted from presenting signs and symptoms?

Can the optimum artificial tear treatment for dry eye disease be predicted from presenting signs and symptoms?

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

High molecular weight hyaluronan decreases oxidative DNA damage induced by EDTA in human corneal epithelial cells

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