Effectiveness of tDCS blinding protocol in a sham-controlled study

Dinn, Wayne M.; Göral, Fatma; Adıgüzel, Sibel; Karamürsel, Saçit; Fregni, Felipe; Ayçiçeği-Dinn, Ayşe

doi:10.1016/j.brs.2017.01.188

Cited by 13 publications

(10 citation statements)

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“…At the end of the study participants were asked to identify at which session they had received either sham or active anodal tDCS. Only 16 out of the 54 participants (29.6% of the sample; nine in the left DLPFC group, seven in the right DLPFC group) correctly identified the tDCS sessions assignment (comparable to other recent studies testing the effectiveness of tDCS blinding protocols, e.g., Dinn et al, 2017). Therefore, our tDCS montage effectively blinded stimulation session assignation.…”

Section: Attentional Disengagementsupporting

confidence: 78%

Neurocognitive mechanisms behind emotional attention: Inverse effects of anodal tDCS over the left and right DLPFC on gaze disengagement from emotional faces

Sánchez-López

Vanderhasselt

Allaert

et al. 2018

Cogn Affect Behav Neurosci

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Our findings support a lateralized role of left and right DLPFC activity in enhancing/worsening the top-down regulation of emotional attention processing. These results support the rationale of new therapies for affective disorders aimed to increase the activation of the left over the right DLPFC in combination with attentional control training, and identify specific target attention mechanisms to be trained.

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Section: Attentional Disengagementsupporting

confidence: 78%

Neurocognitive mechanisms behind emotional attention: Inverse effects of anodal tDCS over the left and right DLPFC on gaze disengagement from emotional faces

Sánchez-López

Vanderhasselt

Allaert

et al. 2018

Cogn Affect Behav Neurosci

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“…The same parameters were used for sham stimulation, except the device shuts off after 3% of the active stimulation time, resulting in 54 s of active stimulation. This brief period of active stimulation is not known to produce active neurological effects, but does ensure blinding because it is associated with common side effects of active tDCS, such as tingling and itching under the electrodes (Dinn et al, 2017 ; Gandiga et al, 2006 ; Valiengo et al, 2020 ). For a full description of the tDCS parameters, please see Rajji et al ( 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Enhancing Cognition in Older Persons with Depression or Anxiety with a Combination of Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS): Results of a Pilot Randomized Clinical Trial

et al. 2021

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Objectives Individuals with subjective memory complaints and symptoms of depression and/or anxiety are at high risk for further cognitive decline, and possible progression to dementia. Low-burden interventions to help slow or prevent cognitive decline in this high-risk group are needed. The objective of this study is to assess the feasibility of combining Mindfulness-Based Stress Reduction (MBSR) with transcranial direct current stimulation (tDCS) to increase putative benefits of MBSR for cognitive function and everyday mindfulness in depressed or anxious older adults with subjective cognitive decline. Methods We conducted a two-site pilot double-blind randomized sham-controlled trial, combining active MBSR with either active or sham tDCS. The intervention included weekly in-class group sessions at the local university hospital and daily at-home practice. Anodal tDCS was applied for 30 min during MBSR meditative practice, both in-class and at-home. Results Twenty-six individuals with subjective cognitive complaints and symptoms of depression and/or anxiety were randomized to active ( n = 12) or sham tDCS ( n = 14). The combination of MBSR and tDCS was safe and well tolerated, though at-home adherence and in-class attendance were variable. While they were not statistically significant, the largest effect sizes for active vs. sham tDCS were for everyday mindfulness ( d = 0.6) and social functioning ( d = 0.9) ( F (1,21) = 3.68, p = 0.07 and F (1,21) = 3.9, p = 0.06, respectively). Conclusions Our findings suggest that it is feasible and safe to combine tDCS with MBSR in older depressed and anxious adults, including during remote, at-home use. Furthermore, tDCS may enhance MBSR via transferring its meditative learning and practice into increases in everyday mindfulness. Future studies need to improve adherence to MBSR with tDCS. Trial Registration ClinicalTrials.gov (NCT03653351 and NCT03680664). Supplementary Information The online version contains supplementary material available at 10.1007/s12671-021-01764-9.

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“…For the active tDCS condition, the device was programed to deliver the electrical current at 2.5 mA for 20 min, with a current density under the surface electrodes of 0.1 mA/cm 2 . For the sham tDCS condition, the device was programed to have a 60‐second ramp up/down to the desired current intensity (2.5 mA) delivered at the beginning of the 20‐minute period and a 60‐second ramp up/down delivered at the end of the 20‐minute period, with no current otherwise delivered during the session 24,25 …”

Section: Methodsmentioning

confidence: 99%

“…For the sham tDCS condition, the device was programed to have a 60-second ramp up/down to the desired current intensity (2.5 mA) delivered at the beginning of the 20-minute period and a 60-second ramp up/down delivered at the end of the 20-minute period, with no current otherwise delivered during the session. 24,25 At the end of the study, blinding integrity was assessed by participant's guess of assigned condition.…”

Section: Transcranial Direct Current Stimulationmentioning

confidence: 99%

Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study

Pilloni

Choi

Shaw

et al. 2020

Ann Clin Transl Neurol

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Objective: To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in multiple sclerosis (MS). Methods: MS participants were recruited for a double-blind, parallel-arm, randomized, sham-controlled trial and assigned to 10 sessions (5 d/wk for 2 weeks) of either active or sham tDCS paired with unloaded cycling for 20 minutes. Stimulation was administered over the left M1 cortex (2.5 mA; anode over C3/cathode over FP2). Gait spatiotemporal parameters were assessed using a wearable inertial sensor (10-meter and 2-minute walking tests). Measurements were collected at baseline, end of tDCS intervention, and 4-week postintervention to test for duration of any benefits. Results: A total of 15 participants completed the study, nine in the active and six in the sham condition. The active and sham groups were matched according to gender (50% vs. 40% female), neurologic disability (median EDSS 5.5 vs. 5), and age (mean 52.1 AE 12.9 vs. 53.7 AE 9.8 years). The active group had a significantly greater increase in gait speed (0.87 vs. 1.20 m/s, p < 0.001) and distance covered during the 2-minute walking test (118.53 vs. 133.06 m, p < 0.001) at intervention end compared to baseline. At 4-week follow-up, these improvements were maintained (baseline vs. follow-up: gait speed 0.87 vs. 1.18 m/s, p < 0.001; distance traveled 118.53 vs. 143.82 m, p < 0.001). Interpretation: Multiple sessions of tDCS paired with aerobic exercise lead to cumulative and persisting improvements in walking and endurance in patients with MS.

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Effectiveness of tDCS blinding protocol in a sham-controlled study

Cited by 13 publications

References 0 publications

Neurocognitive mechanisms behind emotional attention: Inverse effects of anodal tDCS over the left and right DLPFC on gaze disengagement from emotional faces

Neurocognitive mechanisms behind emotional attention: Inverse effects of anodal tDCS over the left and right DLPFC on gaze disengagement from emotional faces

Enhancing Cognition in Older Persons with Depression or Anxiety with a Combination of Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS): Results of a Pilot Randomized Clinical Trial

Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study

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