Effectiveness of Treatment of Rifampicin-Resistant Tuberculosis Combined With Alcohol Dependence Syndrome

Abstract

Rifampicin-resistant tuberculosis (RR-TB) – multi-drug and extensively drug-resistant tuberculosis (MDR and XDR) – is a global problem. Purpose of the work. To study the features of RR-TB combined with alcohol dependence syndrome (ADS). Material and Methods. A total of 420 patients with active pulmonary TB were examined. All patients were divided into groups depending on the presence or absence of ADS. The patients with ADS were referred to the main groups (MG), those without ADS – to the comparison groups (CG). Results. When evaluating the outcome of the main course of treatment in patients with MDR-TB without ADS, the indicator of "successful treatment" was achieved in 88.6% of patients, and in those with MDR-TB combined with ADS – in 58.0% (<0.05). The indicator "successful treatment" was confirmed only in 26.8% of patients with MBT XDR. When XDR-TB was combined with ADS the indicator of "successful treatment" was obtained in 20.4% of patients, the outcome "death" was present in 52.3%, all cases due to TB. In the treatment of XDR-TB without ADS, "successful treatment" was achieved in 65.4% cases, the outcome "death" was in 11.5%. Conclusions. RR-TB in combination with alcohol dependence syndrome is a serious problem. It has been established that the absence of alcohol dependence syndrome in patients with MDR-TB allows for effective anti-TB treatment and good results.