Background. Tuberculosis is still one of the urgent medical and social problems and poses a threat to human health around the world. Purpose of work: To study the features of rifampicin-resistant tuberculosis in male and female patients with alcohol dependence syndrome. Material and methods. The subjects were 219 patients with active rifampicin-resistant pulmonary tuberculosis and a diagnosis of alcohol dependence syndrome. During the study, two groups of patients were formed: group I – the main group (n=33) – included females with rifampicin-resistant pulmonary tuberculosis and alcohol dependence syndrome, group II – the comparison group (n=186) – was composed of males with rifampicin-resistant pulmonary tuberculosis and alcohol dependence syndrome. Results. Termination of bacterial excretion, confirmed by the bacteriological method, was obtained in 60.6% of the patients in the main group and in 57.2% of the patients in the comparison group (p>0.05). The analysis of radiological data (plain chest radiograph, linear tomogram) showed that closure of the decay cavities in the lungs was observed only in 6 (28.6%) and 50 (49.1%) cases (p<0.05), respectively. Conclusions. The modern social picture of rifampicin-resistant tuberculosis is represented by working-age individuals suffering from alcohol dependence syndrome, those who are not employed, women of reproductive age.

Rifampicin-resistant tuberculosis (RR-TB) – multi-drug and extensively drug-resistant tuberculosis (MDR and XDR) – is a global problem. Purpose of the work. To study the features of RR-TB combined with alcohol dependence syndrome (ADS). Material and Methods. A total of 420 patients with active pulmonary TB were examined. All patients were divided into groups depending on the presence or absence of ADS. The patients with ADS were referred to the main groups (MG), those without ADS – to the comparison groups (CG). Results. When evaluating the outcome of the main course of treatment in patients with MDR-TB without ADS, the indicator of "successful treatment" was achieved in 88.6% of patients, and in those with MDR-TB combined with ADS – in 58.0% (<0.05). The indicator "successful treatment" was confirmed only in 26.8% of patients with MBT XDR. When XDR-TB was combined with ADS the indicator of "successful treatment" was obtained in 20.4% of patients, the outcome "death" was present in 52.3%, all cases due to TB. In the treatment of XDR-TB without ADS, "successful treatment" was achieved in 65.4% cases, the outcome "death" was in 11.5%. Conclusions. RR-TB in combination with alcohol dependence syndrome is a serious problem. It has been established that the absence of alcohol dependence syndrome in patients with MDR-TB allows for effective anti-TB treatment and good results.

Background: At present, despite the generally favorable pathomorphosis of tuberculosis (TB), a number of factors that have a negative impact on the epidemiological situation, clinical manifestations and treatment outcomes remain. Objective: To determine the role of aggravating factors in the development of destructive pulmonary tuberculosis. Material and methods: A prospective cohort study was conducted. The patients who were admitted to the inpatient department of the Grodno Regional Clinical Center "Phthisiology", as well as to the Republican Tuberculosis Hospital "Novoelnya" were examined. Depending on the prevailing aggravating factor, the patients were divided into 10 groups. In addition, 2 more groups of patients with the presence of extensive drug resistance of mycobacterium tuberculosis (XDR MBT) were formed. The obtained results indicate a significant negative influence of aggravating factors on the formation of destructive processes in the lungs. As more significant cases in terms of these factors should be considered the patients with TB, accompanied by diabetes mellitus (DM), alcohol dependence syndrome (ADS), chronic nonspecific respiratory diseases (HNRD), as well as those who arrived from correctional labor institutions and those with the presence of several factors at the same time. Results: The analysis of the obtained results shows that in all cohorts of patients, the frequency of the decay cavities exceeds that in patients with pulmonary tuberculosis without the presence of significant risk factors. Conclusions: The results obtained indicate that the frequency of the formation of destructive forms of tuberculosis in MDR-TB depends on a number of aggravating factors. The most significant of them in this regard are DM, the presence of several factors at the same time, ADS, staying at correctional labor institutions as well as HNRD. Factors such as contact or diseases of the gastrointestinal tract do not have a significant effect on the formation of destruction in the lungs in MDR-TB. In the presence of XDR-TB, the highest frequency of destructive forms (over 70%) is observed, it reaching 76.0% in patients with XDR-TB combined with ADS.