Aim:The present study aimed to compare the efficacy of 4% Artpharmadent anesthetic solution compared to 2% Mepecaine-L anesthetic solution in extraction of badly decayed mandibular first primary molar for infiltration in children aged from 6 to 8 years.Methodology: Twenty children with 20 badly decayed mandibular first primary molars indicated for extraction divided randomly into two equal groups (n= 10), group A received 4% Artpharmadent and group B received 2% Mepecaine-L anesthetic solution for infiltration. Intraoperative pain, the need for supplemental injection during extraction, adverse effects following the anesthetic injection, and the clinical success of the treatment were evaluated for both groups.Results: Both groups showed nearly similar results regarding intraoperative pain using Wong-Baker Face Pain Scale (WBFPS), and Sound, eyes, and motor (SEM) scale, regarding the need for supplemental injection during the extraction, and the adverse effects following the anesthetic injection (non-significant difference statistically).Conclusions: Both the 4% Artpharmadent and 2% Mepecaine-L are equally effective in controlling intraoperative pain during the extraction of mandibular molars and both are safe when used in children.