Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia

Jung, Jin-Ah; Choi, Byung‐Moon; Cho, S.H.; Choe, Sang Min; Ghim, Jong-Lyul; Lee, H.M.; Roh, Young Jin; Noh, Gyu Jeong

doi:10.1093/bja/aeq040

Cited by 54 publications

(53 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…reported that the pharmacodynamics and pharmacokinetic properties of this formulation were “substantially similar” to the widely available propofol formulation, but the pain on injection of this nonlipid preparation was a lot more. [11] Another lipid-free preparation of propofol has been developed containing sulfobutylether-ß-cyclodextrin and water, but it does not reduce pain on injection. [12]…”

Section: Different Formulations Of Propofolmentioning

confidence: 99%

Pain on propofol injection: Causes and remedies

DeSousa

2016

Indian J Pharmacol

View full text Add to dashboard Cite

Pain on propofol injection (POPI) is a minor problem that all anesthetists face every day. Introduction of several new formulations and hundreds of clinical trials have failed to find its remedy with just one intervention in all patients. This article highlights the causes of POPI and interventions that are used to eliminate this pain in current practice. Relevant articles from Medline and Embase databases were searched and included in this descriptive review with the following conclusions: (1) POPI is due to irritation of venous adventitia leading to release of mediators such as kininogen from kinin cascade. (2) When two or more drugs or measures are used, the incidence of POPI decreases considerably. Hence, the approach to eliminating POPI should be multimodal. (3) Any regimen that includes a drug having local anesthetic effect combined with central sedative/analgesic and rapid injection into a large vein should definitely reduce the risk of POPI to negligible levels.

show abstract

Section: Different Formulations Of Propofolmentioning

confidence: 99%

Pain on propofol injection: Causes and remedies

DeSousa

2016

Indian J Pharmacol

View full text Add to dashboard Cite

show abstract

“…Essa formulação apresenta maior fração livre e menor distribuição tecidual (JUNG et al, 2010), resultado este diferente do observado por MOREY et al (2006a) Não foram observadas diferença entre as ASC no EMU e NANO, assim como descrito por CHO et al (2010). Entretanto, os valores no NANO foram maiores, refl etindo as Cp encontradas em menor distribuição lipídica da nanoemulsão (JUNG et al, 2010).…”

Section: Resultsunclassified

Farmacocinética do propofol em nanoemulsão em cães

et al. 2013

View full text Add to dashboard Cite

RESUMO O propofol em nanoemulsão é uma nova formulação constituída por sistemas nanoemulsionados, caracterizado pela ausência do veículo lipídico. A modifi cação do veículo pode 2, 5, 10, 15, 30, and 60 minutes after the bolus dose, and after the end of the infusion at fi ve, 10, 15, 30, 60, and 90 minutes and 2, 3, 4, 6, 10, and 24 hours. There were no signifi cant differences in the evaluated pharmacokinetics parameters that included volume of distribution, clearance, elimination rate constant, half-life, and distribution constants, demonstrating that propofol nanoemulsion has no pharmacokinetics differences when compared to the traditional formulation.

show abstract

“…This micro-emulsion was found to be equally safe and effective (mean infusion rate-6.2 vs 6.3 mg/kg/hour); it caused more severe injection pain (median VAS 72 mm vs 11.5mm) which was more frequent (81.9% vs 29.2%)and was reported to be associated with a high aqueous free propofol concentration (63.3 vs 12.4 µgm/ml in Diprivan.) [15] 2.2 Other Causes of propofol painImmediate pain due to injection of propofol results from its direct irritant effect. Pain originates from afferent nerve endings between intima and media of the veins via myelinated A-delta fibres.…”

Section: Discussion 21 Different Formulations Of Propofol Derived Fomentioning

confidence: 99%

Propofol – A Gallery of Different Formulations and Methods to Alleviate Pain on Injection

Gadre¹

2017

jmscr

View full text Add to dashboard Cite

Propofol is a popular intravenous (IV) anaesthetic agent both for induction and maintenance. The initial formulations were potent lipid emulsions; efforts to overcome their drawbacks have altered propofol preparation over the decades. Propofol soybean emulsion has been largely acceptable because it is composed of substances endogenous to the body. Pain on injection, allergic reactions, contamination and hyperlipidaemia are the risk factors that occur frequently. Pain on injection is still an unsolved clinical problem during anaesthesia. Various pre-treatment and induction techniques that have been investigated to minimize the incidence of pain have been discussed here and will find the interest of the readers.

show abstract

Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia

Abstract: Aquafol was as effective and safe as Diprivan, but caused more severe and frequent injection pain. Aquafol demonstrated similar pharmacokinetics to Diprivan.

Cited by 54 publications

References 27 publications

Pain on propofol injection: Causes and remedies

Pain on propofol injection: Causes and remedies

Farmacocinética do propofol em nanoemulsão em cães

Propofol – A Gallery of Different Formulations and Methods to Alleviate Pain on Injection

Contact Info

Product

Resources

About