effectiveness testing of l-carnitine on the quality of spermatozoa and testosterone hormone in white rats (Rattus norvegicus) feeding with high fat

Abstract

This study aims to determine the increase in the quality of spermatozoa and testosterone after giving L-carnitine to white rats (Rattus norvegicus). This study was conducted by giving L-carnitine as a treatment for 42 days in white rats with a dose variation of 100 mg/kg bw, 150 mg/kg bw, and 200 mg/kg bw and user controls as a comparison. The variables observed in this study were the quality of spermatozoa, namely: morphology, motility, viability, membrane integrity, and seeing the levels of the hormone testosterone. The research data were processed using a computer statistical program (SPSS 22.0 for Windows) using the One Way Anova test. The results showed that giving high doses of L-carnitine supplements for a long time could cause decreased spermatozoa quality, namely: morphology, motility, viability, membrane integrity and decreased levels of the hormone testosterone.

Renal histological effects of mebeverine drug on pregnant white rats and their fetuses during late period of pregnancy

“…The results of the microscopic examination of the tissue sections in the untreated pregnant female rats from the control group showed the normal structure of the kidney tissue for a pregnancy period of 20 daysas shown in the figures (1,4), while the structure of the kidneys revealed different pathological changes in the tissue of the groups of pregnant female rats treated with mebeverine drug at concentration of (0.96)mg/kg of body weight for the same period of pregnancy compared to the control group,these pathological effects were represented by shrinkage and necrosis of the renal glomeruli and their damage, in addition to hemorrhage, congestion and disintegration of some renal glomeruli, dilation of Bowman's capsule and the damage of its wall,as for the renal tubules, they were also affected and they suffered from the separation of the inner lining from the basement membrane in some tubules,the walls of some renal tubules were destroyed, congestion and bleeding in others, necrosis in the walls of some renal tubules, and bleeding and necrosis in the renal tissue of the kidneys as shown in figures (2,35,6,7,8,9,10,11,12,13,14,15,16,17,18), and the fetuses kidneys were also greatly affected when pregnant female rats were treated with mebeverine for 20 days of pregnancy,in addition to the infiltration of inflammatory cells in the renal tissue, as is evident in the figures (20,21,22,24,25,26,27,28,29,30,31,31,33,34,35,36) when compared with the kidney tissue in the control group as shown in the figures (19,23), mebeverine drug belongs to the group of anticholinergic drugs that work to reduce the effects of the neurotransmitter acetylcholine in the c...…”

effect of rusavastatin on glycemic index in hypercholesterolemic adult male rats

“…In this study one-way ANOVA used for performing statistical analysis. Least significant differences (LSD) to assess significant differences among means of the groups by using the SAS [9].…”

Comparison of serum troponin level and echocardiographic parameters between male and femal patients with ACS

“…Studies regarding gender-specific lower thresholds for women for the diagnosis of acute myocardial infarction have not shown consistent results: Shah et al proposed that women-specific lower diagnostic thresholds for hs-cTn may double the diagnosis of myocardial infarction in women, and identify those at high risk of re-infarction and death. 12 Kuan Ken Lee etal report that use of a hs-cTnI assay with sex-specific thresholds identified 5 times as many additional women with myocardial injury than men, such that the proportion of women and men with myocardial injury is now equivalent. Despite this increase, women remain less likely than men to receive treatment for myocardial infarction, and the rates of subsequent myocardial infarction or cardiovascular death were not substantially reduced in either women or men following the implementation of high-sensitivity troponin testing into clinical practice.…”