Effectivity of Contact Lens Disinfection Systems Against Acanthamoeba culbertsoni

Connor, Charles G.; Hopkins, Sara L.; Salisbury, Richard D.

doi:10.1097/00006324-199102000-00009

Cited by 22 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of some previous studies are similar 1011 14 28 In contrast, Davies et al 13 and Silvany et al 27found that Hydrocare killed cysts of Acanthamoeba within 4 hours.…”

Section: Discussionmentioning

confidence: 68%

“…14 28 29 37 However, Silvany et al 27 determined that although a 0.00005% PAPB solution was effective at 12 hours against A castellanii (strain ATCC 30868), it was not effective against A polyphaga cysts even at 24 hours. At a higher concentration—namely, 0.0015%, PAPB was found to be ineffective against Acanthamoeba cysts by Connor et al 28 and Hugo et al 30 It is relevant that a 0.0015% PAPB solution caused increased corneal staining by fluorescein, indicating sloughing of cells, compared with control eyes 31…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Acanthamoeba activity of contact lens solutions

Niszl

Markus

1998

British Journal of Ophthalmology

View full text Add to dashboard Cite

Aims-This study was undertaken to investigate the eVects of contact lens disinfecting solutions on strains of Acanthamoeba from the United Kingdom and southern Africa and to compare the results with those of other researchers. No information was previously available for southern African isolates. Methods-11 contact lens solutions were tested on cysts of 10 strains of Acanthamoeba. Results-Not all solutions used in the study were eVective, with some for hard and gas permeable contact lenses being more satisfactory than those for soft contact lenses. The most eVective of the gas permeable and hard contact lens solutions tested was Transoak (0.01% (wt/vol) benzalkonium chloride), which killed cysts of all strains within 4 hours of exposure. Oxysept 1 (31 mg hydrogen peroxide/ml) was the best soft contact lens solution tested. It eliminated cysts of certain strains within 4 hours, whereas cysts of other strains were only inactivated within either 8 or 72 hours. Conclusions-Manufacturers should be aware of the killing time for Acanthamoeba by contact lens solutions and should provide appropriate guidelines for the use thereof. The killing time for cysts of the African and UK isolates studied is, in general, similar. Therefore, it must in the present state of knowledge be assumed that usage guidelines suggested in the UK are also appropriate for travellers to South Africa and for local residents in South Africa.

show abstract

“…The results of some previous studies are similar 1011 14 28 In contrast, Davies et al 13 and Silvany et al 27found that Hydrocare killed cysts of Acanthamoeba within 4 hours.…”

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Anti-Acanthamoeba activity of contact lens solutions

Niszl

Markus

1998

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…associated with keratitis (Elder et al, 1994;Hay et al, 1994;Seal et al, 1996;Kim & Hahn, 1999). However, very low concentrations of PHMB (0.00005%), polyaminopropyl biguanide (0.00005%) and the QAC polyquaternium-1 (0.055-0.001%) were reported to be inactive against A. castellanii (Penley et al, 1989;Davies et al, 1990;Silvany et al, 1990;Zanetti et al, 1995;Cengiz et al, 2000), A. polyphaga (Penley et al, 1989;Davies et al, 1990;Silvany et al, 1990) and A. culbertsoni (Connor et al, 1991). Several investigations showed that the concentration of polymeric biguanides in multipurpose solutions commercially available was not cysticidal within the manufacturer's recommended contact time (Buck et al, 1998;Kilvington, 1998;Niszl & Markus, 1998).…”

Section: Activity Of Cationic Biocidesmentioning

confidence: 99%

Free-living amoebae and their intracellular pathogenic microorganisms: risks for water quality

Thomas¹,

McDonnell²,

et al. 2010

View full text Add to dashboard Cite

An increasing number of microorganisms, including bacteria but also viruses and eukaryotes, have been described as benefiting from interaction with free-living amoebae (FLA). Beneficial interaction can be due to resistance to predation conferring ecological advantage, intracellular survival and/or intracellular proliferation. This review highlights the potential risk associated with amoebae by listing all known pathogenic microbial species for which growth and/or survival promotion by FLA (mainly Acanthamoeba spp.) has been demonstrated. It focuses on the susceptibility of amoebal and intra-amoebal bacteria to various categories of biocides, the known mechanisms of action of these biocides against trophozoites and cysts and the various methods used to demonstrate efficacy of treatments against FLA. Brief descriptions of FLA ecology and prevalence in domestic/institutional water systems and their intrinsic pathogenicity are also presented. The intention is to provide an informed opinion on the environmental risks associated with the presence of FLA and on the survival of cysts following biocidal treatments, while also highlighting the need to conduct research on the roles of amoebae in aquatic ecosystems.

show abstract

“…6,9,22 Thus, Ghajar et al 20 and Connor et al 21 reported that Miraflow demonstrated some activity against Acanthamoeba trophozoites and cysts in a simulated-use laboratory study. However, they did not investigate the differences in activity for different strains of Acanthamoeba.…”

Section: Discussionmentioning

confidence: 98%

“…19 Ghajar et al 20 showed that Miraflow showed some activity against trophozoites and cysts of A. castellanii strain ATCC 30234. Connor et al 21 also showed in a laboratory study that the number of A. culbertsoni cysts on SCLs was reduced when they were soaked in Miraflow. These studies suggested that Miraflow showed antiAcanthamoeba activity; however, both investigations used only a single strain of Acanthamoeba, namely, A. castellanii or A. culbertsoni.…”

mentioning

confidence: 96%