Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats

Ye, Jian; Xiao, Rong-Xue; Wang, Xu; He, Ruiqing; Liu, Zongjun; Gao, Junqing

doi:10.1186/s12872-022-02980-4

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…2 Acute myocardial infarction (AMI) is a form of myocardial ischemic necrosis that results from a reduction or cessation of blood supply in the coronary artery. 3 The pathophysiological process of myocardial injury following AMI involves inflammation, immune response, apoptosis, autophagy, and mitochondrial dysfunction. 4 Oxidative stress and inflammatory response are crucial factors in the development of AMI.…”

Section: Introductionmentioning

confidence: 99%

Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling

Li,

Zhu,

Chang

et al. 2023

Exp Biol Med (Maywood)

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The objective of the present investigation was to assess the protective impact of gentiopicroside (GPS) on acute myocardial infarction (AMI) through the modulation of NF-E2-related factor 2 (Nrf2)/nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) signaling. H9c2 cells were subjected to varying concentrations of GPS, and subsequently, the cells and Sprague–Dawley (SD) rats were segregated into control, model, GPS, t-BHQ (an Nrf2 activator), and GPS + ML385 (an Nrf2 inhibitor) groups. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were analyzed. Reactive oxygen species (ROS) and cell apoptosis were assessed, while Nrf2 and the expression of the NLRP3 inflammatory body signal pathway were evaluated using western blot and immunofluorescence techniques. The infarct area and pathological changes were also examined. Treatment with varying doses of GPS resulted in increased viability of H9c2 cells. Notably, the model group exhibited significantly elevated levels of cell apoptosis, MDA, and ROS compared to the control group, while SOD and Nrf2 levels were significantly reduced. Furthermore, the expression of NLRP3, cleaved caspase-1, interleukin (IL)-1β, and IL-18 were found to be augmented. Following the implementation of GPS in cells and animals, there was a notable reduction in MDA and ROS levels, a decrease in the rate of cellular apoptosis, and a mitigation of inflammation scores. In addition, there was an increase in the expression of SOD and Nrf2. However, the protective effects of GPS were negated when co-administered with ML385. GPS exhibits therapeutic properties in AMI rats by activating Nrf2 expression, thereby reducing the NLRP3 inflammatory body and alleviating the inflammatory response and oxidative stress of myocardial cells. GPS may hold promise as a potential drug for the treatment of AMI.

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Section: Introductionmentioning

confidence: 99%

Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling

Li,

Zhu,

Chang

et al. 2023

Exp Biol Med (Maywood)

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Effects of renal denervation on the incidence and severity of cardiovascular diseases

Katsurada,

Kario

2024

Hypertens Res

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A Closer Review of Therapeutic Effects of Renal Denervation on the Cardiorenal Syndrome: The Role of Classical and Non-Classical Renin-Angiotensin System Axes

Maneshian,

Kaffash Farkhad,

Shahraki

2023

J Clin Res Paramed Sci

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: The “Cardiorenal Syndrome (CRS) “includes a simultaneous heart-kidney dysfunction in such a way that damage in one organ subsequently leads to damage in another and vice versa. Although for the first time in a classification in 2008, two main groups called cardiorenal and reno-cardiac (based on the onset of the disease in each organ) were used for this term, but today there are five main classifications for it. Various factors take part in this syndrome pathophysiology, including endotoxemia, inflammatory processes, metabolic derangements, infections, imbalance in neurohormones secretion, venous congestion and immunological dysfunction. But the main cause of this syndrome' onset in many cases is over-activity of renal sympathetic nerves and subsequently increased interaction with the stimulated renin-angiotensin system (both classical and non-classical axes). Regarding this fact, today renal denervation is known as a useful therapeutic approach in solving the disorders of this syndrome, which its safety and efficacy have been proven in many experimental and clinical studies. Respecting the above information, the aim of this study is to investigate the therapeutic effects of renal denervation in solving CRS disorders in more details, relying on the results of experimental and human studies in this field. The effects of using renin angiotensin blockers and other treatment methods for this syndrome have also been mentioned.

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Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats

Cited by 3 publications

References 39 publications

Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling

Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling

Effects of renal denervation on the incidence and severity of cardiovascular diseases

A Closer Review of Therapeutic Effects of Renal Denervation on the Cardiorenal Syndrome: The Role of Classical and Non-Classical Renin-Angiotensin System Axes

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