Effects and mechanisms of kerosene use-related toxicity

Maiyoh, Geoffrey K.; Njoroge, Rachel W.; Tuei, Vivian C.

doi:10.1016/j.etap.2015.05.010

Cited by 32 publications

(23 citation statements)

References 72 publications

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“…The fur of rats administered with TMO became rough and started to peel off. This appears to be in agreement with earlier observations with other petroleum based products like kerosene observed to cause dermal irritation and sensitization, skin lesions and dermatitis (Maiyoh et al., 2015). This may be attributable to the presence of certain chemical substances such as the carcinogenic polycyclic aromatic hydrocarbons (PAHs) in TMO.…”

Section: Discussionsupporting

confidence: 93%

Transformer mineral oil ingestion induces systemic sub-acute toxicity in Wistar rats

Otunga

Maiyoh

Macharia

et al. 2019

Heliyon

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We investigated the potential toxicities associated with the sub-acute ingestion of transformer mineral oil (TMO) at a heated low dose (HLD-50 mg/kg), heated high dose (HHD-500 mg/kg) and unheated high dose (UHD-500 mg/kg) in Wistar rats. There were increases in red blood cells and haemoglobin levels in HHD females and UHD males respectively versus control. The serum total proteins, albumin, and creatinine of the HHD females showed a significant increase versus control. The HHD males and UHD groups showed significant increase in liver malondialdehyde versus control. The livers of HHD groups had bile duct proliferation while those of HLD females and UHD groups showed focal areas of periportal chronic inflammation. HHD groups had kidneys with mild chronic inflammation and the HHD and UHD groups showed small intestines with chronic inflammation. In conclusion, sub-acute oral administration of TMO induced various degrees of dermal, haematological, hepatic, renal and small-intestinal toxicities in rats.

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Section: Discussionsupporting

confidence: 93%

Transformer mineral oil ingestion induces systemic sub-acute toxicity in Wistar rats

Otunga

Maiyoh

Macharia

et al. 2019

Heliyon

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“…On the other hand, pneumatoceles emerged in the right lung accompanied by niveau formation seen on the CT scan. Similarly, the development of pneumothorax, pneumatoceles, and bronchopleural fistulas has been reported as secondary effects of kerosene aspiration in some cases [10] , [13] . Two months after the initiation of corticosteroid treatment, the consolidations and pneumatoceles disappeared, and only some bronchiectasis remained, with pleural and interlobular septal thickening seen on the CT scan.…”

Section: Discussionmentioning

confidence: 87%

“…Kerosene is a low-viscosity hydrocarbon liquid that spreads over large areas of the lining of the lungs. Aspiration of kerosene primarily induces inflammation and loss of surfactant [10] . The death rate for kerosene aspiration pneumonia is as high as 4%–10% [11] .…”

Section: Discussionmentioning

confidence: 99%

A severe case of acute exogenous lipoid pneumonia treated with systemic corticosteroid

Yasui

Yokomura

Suda

2016

Respiratory Medicine Case Reports

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Acute exogenous lipoid pneumonia is a rare disorder in adults. A treatment of choice for lipoid pneumonia has not been established, and systemic corticosteroid use remains controversial. We report the case of a 32-year-old man with schizophrenia who presented with kerosene-induced acute exogenous lipoid pneumonia that was treated with a systemic corticosteroid. In this case, supportive therapy did not improve the patient's condition, so systemic corticosteroid therapy was commenced four days after he ingested the kerosene. After corticosteroid commencement, the patient's symptoms and hypoxia improved within a few days. Although some radiological characteristics of this disorder have been reported previously, the process of radiological improvement of exogenous lipoid pneumonia is not well known. In this case, computed tomography findings changed dramatically after corticosteroid therapy was initiated. Extensive bilateral consolidations that were observed on admission improved. Although pneumatoceles developed two weeks after corticosteroid commencement, they were nearly gone after two months of the treatment. While corticosteroid therapy is not suitable for all cases, it should be considered for severe or refractory cases.

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“…Ungewollte Aspiration von Petroleum wurde zudem bei Feuerspuckern beschrieben [3]. Neben der toxischen Wirkung auf den Respirationstrakt werden ZNS-Effekte (Benommenheit, Ataxie, Krampfanfälle, Koma) und Dermatitiden bei chronischer Exposition beobachtet [4].…”

Section: Diskussionunclassified

Aspirationspneumonie nach Petroleumingestion – Lampenöl ist kein Heilmittel

Neupert

2020

Dtsch Med Wochenschr

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Zusammenfassung Anamnese Wir stellen den Fall eines 78-jährigen Mannes vor, der nach Einnahme einer kleinen Menge Petroleum eine Aspirationspneumonie mit konsekutiver Sepsis entwickelt hatte. Untersuchungen und Diagnose Da zunächst von einer versehentlichen Aufnahme ausgegangen worden war, sollte die Verdachtsdiagnose einer demenziellen Erkrankung abgeklärt werden. Eine ausführliche Exploration des Patienten konnte mithilfe fremdanamnestischer Angaben eine psychiatrische Erkrankung ausschließen. Stattdessen stellte sich der Glaube an alternativmedizinische Heilungsversprechen als Ursache der Petroleumingestion heraus. Therapie und Verlauf Eine psychiatrische Behandlung war nicht notwendig, während sich die körperliche Verfassung nach antimikrobieller Therapie stabilisierte. Folgerung Das psychiatrische Konsil kann hilfreich sein, um Verhaltensweisen, die auf eine psychische Erkrankung hindeuten, diagnostisch einordnen zu können.

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Effects and mechanisms of kerosene use-related toxicity

Cited by 32 publications

References 72 publications

Transformer mineral oil ingestion induces systemic sub-acute toxicity in Wistar rats

Transformer mineral oil ingestion induces systemic sub-acute toxicity in Wistar rats

A severe case of acute exogenous lipoid pneumonia treated with systemic corticosteroid

Aspirationspneumonie nach Petroleumingestion – Lampenöl ist kein Heilmittel

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