Effects and mechanisms of natural products on Alzheimer’s disease

Yang, Zhijun; Zhou, Dan-Dan; Huang, Siyu; Fang, Aiping; Li, Hua-Bin; Zhu, Huilian

doi:10.1080/10408398.2021.1985428

Cited by 22 publications

(8 citation statements)

References 192 publications

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“…Apoptosis is a kind of programmed cell death that occurs in an ordered and coordinated manner under pathological and physiological conditions and plays a crucial role in organism development and tissue homeostasis [ 106 ]. Apoptosis is associated with TNF-α, ROS and the activation of cysteine-protease and caspases [ 107 ]. During normal conditions, apoptosis is necessary for homeostasis but, in cancer, cells lose the ability to undergo apoptosis-induced death, leading to uncontrolled cell proliferation, which further leads to tumor survival, therapeutic resistance and cancer recurrence [ 108 , 109 ].…”

Section: Effects and Mechanisms Of Curcumin On Cancersmentioning

confidence: 99%

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

et al. 2022

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Cancer is the leading cause of death in the world. Curcumin is the main ingredient in turmeric (Curcuma longa L.), and is widely used in the food industry. It shows anticancer properties on different types of cancers, and the underlying mechanisms of action include inhibiting cell proliferation, suppressing invasion and migration, promoting cell apoptosis, inducing autophagy, decreasing cancer stemness, increasing reactive oxygen species production, reducing inflammation, triggering ferroptosis, regulating gut microbiota, and adjuvant therapy. In addition, the anticancer action of curcumin is demonstrated in clinical trials. Moreover, the poor water solubility and low bioavailability of curcumin can be improved by a variety of nanotechnologies, which will promote its clinical effects. Furthermore, although curcumin shows some adverse effects, such as diarrhea and nausea, it is generally safe and tolerable. This paper is an updated review of the prevention and management of cancers by curcumin with a special attention to its mechanisms of action.

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Section: Effects and Mechanisms Of Curcumin On Cancersmentioning

confidence: 99%

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

et al. 2022

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“…Although the conversion of accumulated soluble and monomeric Aβ to oligomeric and later insoluble fibrillar Aβ is a main pathogenic characteristic in the emergence of AD, it is increasingly evident that diffusible Aβ oligomers are more toxic than insoluble fibrils. Several natural products, such as icariside, honokiol, camellia oil, and (−)-epigallocatechin-3-gallate, have been shown to prevent AD by inhibiting Aβ accumulation and diminishing Aβ toxicity (Yang et al, 2021).…”

Section: K Mp Modul Ate S a β-Induced Toxi Cit Y In Admentioning

confidence: 99%

Kaempferol as a potential neuroprotector in Alzheimer's disease

Nejabati

Roshangar

2022

Journal of Food Biochemistry

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Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is largely associated with cognitive disability, amnesia, and abnormal behavior, which accounts for about two third of people with dementia worldwide. A growing body of research demonstrates that AD is connected to several factors, such as aberrant accumulation of amyloid‐beta (Aβ), increase in the hyperphosphorylation of Tau protein, and the formation of neurofibrillary tangles, mitochondrial dysfunction, and inordinate production of reactive oxygen species (ROS). Despite remarkable efforts to realize the etiology and pathophysiology of AD, until now, scientists have not developed and introduced medications that can permanently cease the progression of AD. Thus, nowadays, research on the role of natural products in the treatment and prevention of AD has attracted great attention. Kaempferol (KMP), one of the prominent members of flavonols, exerts its ameliorative actions via attenuating oxidative stress and inflammation, reducing Aβ‐induced neurotoxicity, and regulating the cholinergic system. Therefore, in this review article, we outlined the possible effects of KMP in the prevention and treatment of AD. Practical applications Kaempferol (KMP) exerts its ameliorative actions against AD via attenuating oxidative stress and inflammation, reducing Aβ‐induced neurotoxicity, and regulating the cholinergic system. The beneficial effects of KMP were addressed in both in vitro and in vivo studies; however, conducting further research can warrant its long‐term effects as a safe agent. Therefore, after confirming its favorable functions in the prevention and treatment of AD, it could be used as a safe and effective agent.

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“…In the case that existing drugs cannot cure AD, a large number of natural products have been reported to have therapeutic potentials for treating AD. Considering their rich nature resources and anti-inflammatory, antioxidant, anti-amyloid and anti-cholinesterase properties, their anti-inflammatory activity has attracted more and more attention for investigation of their application in the treatment of AD [ 23 , 67 , 81 , 82 ]. Usually, they are widely distributed in nature, easily available and less toxic [ 83 ].…”

Section: Application Prospect Of Anti-inflammatory Activity Of Natura...mentioning

confidence: 99%

“…On the other hand, there are emerging future theories for the development of new therapies for AD such as disease modification therapy (DMT), molecular chaperones and natural products [ 20 ]. Natural products have attracted more and more attention, since natural products with anti-inflammatory activity may have certain therapeutic potentials for treating AD [ 7 , 8 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng

Yan

et al. 2023

Molecules

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Alzheimer’s disease (AD) is an age-related chronic progressive neurodegenerative disease, which is the main cause of dementia in the elderly. Much evidence shows that the onset and late symptoms of AD are caused by multiple factors. Among them, aging is the main factor in the pathogenesis of AD, and the most important risk factor for AD is neuroinflammation. So far, there is no cure for AD, but the relationship between neuroinflammation and AD may provide a new strategy for the treatment of AD. We herein discussed the main etiology hypothesis of AD and the role of neuroinflammation in AD, as well as anti-inflammatory natural products with the potential to prevent and alleviate AD symptoms, including alkaloids, steroids, terpenoids, flavonoids and polyphenols, which are available with great potential for the development of anti-AD drugs.

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Effects and mechanisms of natural products on Alzheimer’s disease

Cited by 22 publications

References 192 publications

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

Kaempferol as a potential neuroprotector in Alzheimer's disease

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

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