Effects of 0.005% Latanoprost on Ocular Anterior Structures and Ciliary Body Thickness

Abstract

The increase of ciliary body thickness, which was measured in vivo by ultrasound biomicroscopy and associated with the intraocular pressure-lowering effect, indirectly supports the mechanism of uveoscleral outflow enhancement induced by latanoprost. These data are in agreement with the biochemical hypothesis of the passage of the aqueous flow through the extracellular spaces of the ciliary muscle.

Quantitative Measurements of the Ciliary Body in Eyes With Acute Primary-Angle Closure

“…It was reported that increase of ciliary body thickness was correlated with the IOP-lowering effect of antiglaucoma drugs. 13 In the current study, though IOP-lowering agents were used in all of the APAC eyes (no laser or surgical procedures were performed), ciliary body thickness decreased in APAC eyes. Moreover, higher IOP associated with thinner ciliary body could still be detected.…”

“…14 Ciliary body thickness at the point of the scleral spur (CBT0) 14 and at the distance of 1000 lm (CBT1000) from the scleral spur is defined as described previously. 13 Anterior placement of ciliary body (APCB) is the distance from the most anterior point of ciliary body to the vertical line from the inner wall of the sclera through the scleral spur 14 ; trabecular-ciliary angle (TCA) is the angle between the posterior corneal surface and the anterior surface of the ciliary body. 15 is and the greater the LV is, the thinner the ciliary body is and the more it is anteriorly located.…”

“…14 For ciliary body measurements, radial scans at the 12, 6, 3, and 9 o'clock positions were centered over the limbus, corresponding to the superior, inferior, nasal, and temporal quadrants. The following parameters were measured as described previously [13][14][15] ( Fig. 2): (1) maximum ciliary body thickness (CBTmax), which was the distance from the most inner point of the ciliary processes to the inner wall of sclera or its extended line; (2) ciliary body thickness at the point of the scleral spur (CBT0) and at the distance of 1000 lm (CBT1000) from the scleral spur; (3) anterior placement of ciliary body (APCB), which was the distance from the most anterior point of ciliary body to the perpendicular line from the inner wall of the sclera passing through the scleral spur; (4) trabecularciliary process angle (TCA), which was the angle between the posterior corneal surface and the anterior surface of the ciliary body as described previously.…”

“…Accurate measurement of the ciliary body is possible with UBM. [11][12][13][14] In our previous study, we performed ciliary body measurements in eyes with malignant glaucoma, their fellow eyes, and eyes with primary-angle closure (PAC) or primary-angle closure glaucoma (PACG). 14 Three parameters for the ciliary body thickness and the anterior extension of ciliary body were introduced.…”

Ultrasound Biomicroscopy in Glaucoma: An Update

“…Marchini G et al 68 assessed the effects of 0.005% latanoprost on the anterior segment geometry and ciliary body thickness using ultrasound biomicroscopy.…”