Effects of 1,25(OH)2 vitamin D3 on cytokine production by endometrial cells of women with recurrent spontaneous abortion

Tavakoli, Mitra; Jeddi-Tehrani, Mahmood; Salek-Moghaddam, Alireza; Rajaei, Samira; Mohammadzadeh, Afsaneh; Sheikhhasani, Shahrzad; Kazemi-Sefat, Golnaz-Ensieh; Zarnani, Amir Hassan

doi:10.1016/j.fertnstert.2011.06.075

Cited by 66 publications

(68 citation statements)

References 41 publications

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“…Indeed, in vitro exposure of endometrial cells to vitamin D has been shown to modulate the expression of factors that are appreciated to impact on endometrial receptivity [43][44][45], thus supporting our conjecture. Consistent with our hypothesis, higher midyear UVB intensity was identified as an independent and positive predictor of fresh ET related LBR's (Table 2).…”

Section: Discussionsupporting

confidence: 84%

Donor egg IVF model to assess ecological implications for ART success

Pal

Kidwai

Kayani

et al. 2014

J Assist Reprod Genet

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Purpose Environmental influences on reproductive success are recognized. We hypothesized that location of fertility clinics may influence treatment success and explored this hypothesis utilizing donor egg IVF (IVF) embryo transfer (ET) model. Methods Publicly accessible national registry data (Society for Assisted Reproductive Technology) on fresh & frozen (FET) ET cycles undertaken at participating clinics across North America (n=444 IVF centers) for 2007 were utilized. Information on number of donor egg IVF cycles, live birth (LB) rate following fresh and frozen ET(FET), average number (#) of ET and IVF center's location, geographical coordinates (latitude, longitude, altitude), annualized average temperatures and midyear regional ultraviolet B (UVB) radiation intensity were obtained. Multivariable logistic regression analyses assessed relationship between LBR (in tertile and uppermost versus lesser quartiles) following fresh and FET with geographical coordinates (region and altitude of clinic location) and ecological influences (average temperature and midyear UVB intensity), adjusting for #ET and clinic experience with donor egg IVF. Results Average number of fresh ET, clinic location (region) and midyear UVB intensity were positive predictors of LBR following fresh ET, whereas altitude and annualized average regional temperature demonstrated an inverse relationship with LBR following fresh ET. For FET cycles, #ET, clinic region and altitude were positive determinants of increasing LBR's. Annualized regional temperature and midyear UVB failed to demonstrate any relationship with LB following donor egg FET. Conclusion Our data suggest that ecological influences may relate to donor egg IVF cycle success. Future studies are needed to better elucidate the mechanisms that could explain the observed associations.

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Section: Discussionsupporting

confidence: 84%

Donor egg IVF model to assess ecological implications for ART success

Pal

Kidwai

Kayani

et al. 2014

J Assist Reprod Genet

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“…Elucidation of the immunomodulatory effects of 1,25(OH) 2 D has led to the suggestion that vitamin D might have a role in protecting against spontaneous abortion (Bubanovic 2004). This was supported by ex vivo analyses showing that 1,25(OH) 2 D is able to suppress inflammatory cytokine production by endometrial cells from women with unexplained recurrent spontaneous abortions (Tavakoli et al 2011). More recently, 1,25(OH) 2 D has been shown to potently regulate natural killer cells from women with recurrent miscarriage (Ota et al 2015).…”

Section: Vitamin D and Trophoblast Function: Clinical Implicationsmentioning

confidence: 80%

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Ganguly

Tamblyn

Finn-Sell

et al. 2018

Journal of Endocrinology

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Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH) 2 D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH) 2 D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH) 2 D remains unclear, but is likely to involve localized tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH) 2 D. We have previously described immunomodulatory responses to 1,25(OH) 2 D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH) 2 D as a regulator of trophoblast invasion in early pregnancy. Vitamin D deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date, most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.

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“…Additionally, in a retrospective cohort study of 115 women with antiphospholipid syndrome (APS), median vitamin D levels in APS patients were significantly lower compared to healthy volunteers (n=128), although the authors report possible confounding factors related to provider recommendation of increased sunscreen use in the APS cohort [22]. Tavakoli et al [23] reported similar cytokine profiles and vitamin D expression of whole endometrial cells obtained from women with unexplained recurrent pregnancy loss (n=8) compared to age matched controls (n=8), although the authors do not address the limitations of the small sample size. A recent study evaluated the effect of vitamin D treatment with and without low molecular weight heparin on an antiphospholipid antibody-induced inflammatory response of human first trimester trophoblast (HTR8) and primary trophoblast cell lines [24].…”

Section: Pregnancy Lossmentioning

confidence: 99%

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

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Effects of 1,25(OH)2 vitamin D3 on cytokine production by endometrial cells of women with recurrent spontaneous abortion

Cited by 66 publications

References 41 publications

Donor egg IVF model to assess ecological implications for ART success

Donor egg IVF model to assess ecological implications for ART success

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

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