Effects of 14-weeks betaine supplementation on pro-inflammatory cytokines and hematology status in professional youth soccer players during a competition season: a double blind, randomized, placebo-controlled trial

Nobari, Hadi; Cholewa, Jason M.; Pérez‐Gómez, Jorge; Castillo-Rodríguez, Alfonso

doi:10.1186/s12970-021-00441-5

Cited by 26 publications

(29 citation statements)

References 63 publications

(50 reference statements)

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“…However, the pro-inflammatory pathway may be activated, in eccentric exercise protocols [ 11 , 12 ]. Therefore, optimal exercise protocol should be used for athletes and sedentary people to improve outcomes and prevent musculoskeletal damages, cardiovascular, neurological, and endocrinological side effects [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Baygutalp

Buzdağlı

Ozan

et al. 2021

BMC Sports Sci Med Rehabil

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Background This study aims to determine and compare the effects of exercise modalities with different intensities on the secretion of key inflammation and hypoxia markers in amateur athletes. Methods Twenty-three athletes with a mean age of 20.1 years, living at low altitude (1850 m) participated in this study. The participants' maximal oxygen consumption values (VO2 max) were determined with an incremental cycle exercise test as 54.15 ± 6.14 mL kg min−1. Athletes performed four protocols: at rest, 50% VO2 max, 75% VO2 max and 100% VO2 max (until exhaustion) with one-week intervals. 50% VO2 max, 75% VO2 max sessions were performed continuously for 30 min on a bicycle ergometer and 100% VO2 max session was performed by cycling until exhaustion. Blood samples were obtained at rest and immediately after each exercise session. Serum tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), interleukin-10 (IL-10), and hypoxia inducible factor-1 alpha (HIF-1α) levels were measured. Results There were significant differences in serum TNF-α levels in 75% VO2 max and 100% VO2 max sessions (489.03 ± 368.37 and 472.70 ± 365.21 ng/L, respectively) compared to rest conditions (331.65 ± 293.52 ng/L). Serum CRP levels of 50% VO2 max and 75% VO2 max sessions (1.19 ± 0.50; 1.07 ± 0.52 mg/L) were significantly higher than the rest condition (0.74 ± 0.35 mg/L). There were significant differences in serum IL-10 levels of rest condition and 50% VO2 max; 50% VO2 max, and 100% VO2 max sessions (328.09 ± 128.87; 446.36 ± 142.84; 347.44 ± 135.69; 324.88 ± 168.06 pg/mL). Serum HIF-1α levels were significantly higher in 75% VO2 max session compared to rest (1.26 ± 0.16; 1.08 ± 0.19 ng/mL) (P < 0.05 for all comparisons). Conclusions Both inflammatory and anti-inflammatory pathway is induced on different exercise intensities. Exercise protocols performed until exhaustion may lead to activation of inflammatory pathways and hypoxia-induced damage.

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Section: Introductionmentioning

confidence: 99%

“…The release of pro-inflammatory cytokines and anti-inflammatory cytokines into the circulation in response to exercise varies according to exercise type, duration, and intensity [ 1 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Baygutalp

Buzdağlı

Ozan

et al. 2021

BMC Sports Sci Med Rehabil

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“…For example, decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to reduced lung function [27]. Irisin secretion was found to be linked to physical activity in a previous study.…”

Section: Dear Editormentioning

confidence: 88%

“…Myokines are implicated in the autocrine regulation of metabolism in muscles as well as in the para/endocrine regulation of other tissues and organs including the adipose tissue, liver, and brain and lung through their receptors “muscle–lung cross-talk”. For example, decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to reduced lung function [ 27 ]. Irisin secretion was found to be linked to physical activity in a previous study.…”

Section: Dear Editormentioning

confidence: 99%

Potential Improvement in Rehabilitation Quality of 2019 Novel Coronavirus by Isometric Training System; Is There “Muscle-Lung Cross-Talk”?

Nobari

Fashi

Eskandari

et al. 2021

IJERPH

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The novel Coronavirus Disease 2019 (COVID-19) crisis is now present in more than 200 countries. It started in December 2019 and has, so far, led to more than 149, 470,968 cases, 3,152,121 deaths, and 127,133,013 survivors recovered by 28 April 2021. COVID-19 has a high morbidity, and mortality of 2%, on average, whereas most people are treated after a period of time. Some people who recover from COVID-19 are left with 20 to 30% decreased lung function. In this context, exercise focused on skeletal muscle with minimal lung involvement could potentially play an important role. Regular exercise protects against diseases associated with chronic low-grade systemic inflammation. This long-term effect of exercise may be ascribed to the anti-inflammatory response elicited by an acute bout of exercise, which is partly mediated by muscle-derived myokines. The isometric training system seems to have this feature, because this system is involved with the skeletal muscle as the target tissue. However, no studies have examined the effect of exercise on the treatment and recovery of COVID-19, and, more importantly, “muscle–lung cross-talk” as a mechanism for COVID-19 treatment. It is suggested that this theoretical construct be examined by researchers.

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“…All the players went to the laboratory after 12 h of fasting, and 2 days after the last training session of the team, at eight o'clock in the morning. As in the previous study process (Nobari et al, 2021c ), 10 cc of blood was first taken from the antecubital vein of the players by a qualified phlebotomist. The collected samples were immediately centrifuged, and their serum was removed.…”

Section: Methodsmentioning

confidence: 99%

Association Between Endocrine Markers, Accumulated Workload, and Fitness Parameters During a Season in Elite Young Soccer Players

et al. 2021

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The purpose of this study was to analyze differences between endocrine markers in soccer players, based on playing positions, and correlations between endocrine markers (testosterone, cortisol, growth hormone, and insulin-like growth factor-1), with accumulated workload training and fitness parameters [maximal oxygen uptake (VO2max), countermovement jump (CMJ), and isometric maximal strength (1-RM) of the knee for hamstring (ISH) and quadriceps (ISQ) muscles] during early-, mid-, and end-seasons. Twenty-four elite soccer players under 17 participated in this study. The results showed that there was no difference between levels of the endocrine markers among the different positions of the players. Significant correlations were observed between endocrines parameters and fitness performance (ISQ, ISH, VO2max, and CMJ). Regression analysis showed that 1-RM and VO2max were the best predictors of endocrine markers. These findings demonstrated that the activity profiles of youth soccer players were not influenced by endocrine markers. Also, it may be assumed that endocrines levels can be used to better explain the physical capacities of this population. Finally, endocrines markers may help to predict changes in 1-RM and VO2max.

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Effects of 14-weeks betaine supplementation on pro-inflammatory cytokines and hematology status in professional youth soccer players during a competition season: a double blind, randomized, placebo-controlled trial

Cited by 26 publications

References 63 publications

Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude

Potential Improvement in Rehabilitation Quality of 2019 Novel Coronavirus by Isometric Training System; Is There “Muscle-Lung Cross-Talk”?

Association Between Endocrine Markers, Accumulated Workload, and Fitness Parameters During a Season in Elite Young Soccer Players

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