Effects of 17α-ethinylestradiol on sexual development of the amphipod Hyalella azteca

Vandenbergh, Gert; Adriaens, Dominique; Verslycke, Tim; Janssen, Colin R.

doi:10.1016/s0147-6513(02)00030-1

Cited by 70 publications

(50 citation statements)

References 28 publications

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“…Iopromide Groundwater Australia 0.577 [200] Algae S. subspicatus [158] >10.0 g L [201] Iopromide Germany SPE-HPLC-MS/MS SPE-HPLC-MS 40 [202] Iopromide Germany 50 1600 <50 [203] >1.0 g L…”

Section: Discussionmentioning

confidence: 99%

“…Amphib-ians and reptiles exposed to environmental estrogens showed sex reversal as well as significant changes in secondary sex character-istics [156,157]. Concerning invertebrates such as the amphipod Hyalella azteca it was observed that at sub-lethal concentrations of EE2 (0.1-10 µg L −1 ) sexual development of males was affected [158]. On the other hand, the estrogens E2 and EE2 did not show significant effects on reproduction or survival of C. dubia even at concentrations of 1 and 0.5 mg L −1 , respectively [159].…”

Section: Sex Hormonesmentioning

confidence: 99%

See 1 more Smart Citation

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,302

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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“…Iopromide Groundwater Australia 0.577 [200] Algae S. subspicatus [158] >10.0 g L [201] Iopromide Germany SPE-HPLC-MS/MS SPE-HPLC-MS 40 [202] Iopromide Germany 50 1600 <50 [203] >1.0 g L…”

Section: Discussionmentioning

confidence: 99%

Section: Sex Hormonesmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,302

533

View full text Add to dashboard Cite

show abstract

“…Morphological and histological changes resulting from exposure to EDs have been documented in fish, amphibians, reptiles, mammals, and arthropods (e.g., Gross et al, 2001;Vandenbergh et al, 2003;Schirling et al, 2006). In mysids, morphology and histology have not been considered widely as a measurable endpoint in toxicological studies.…”

Section: Morphology and Histologymentioning

confidence: 99%

Mysid crustaceans as standard models for the screening and testing of endocrine-disrupting chemicals

et al. 2007

Self Cite

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Investigative efforts into the potential endocrine-disrupting effects of chemicals have mainly concentrated on vertebrates, with significantly less attention paid to understanding potential endocrine disruption in the invertebrates. Given that invertebrates account for at least 95% of all known animal species and are critical to ecosystem structure and function, it remains essential to close this gap in knowledge and research. The lack of progress regarding endocrine disruption in invertebrates is still largely due to: (1) our ignorance of mode-of-action, physiological control, and hormone structure and function in invertebrates; (2) lack of a standardized invertebrate assay; (3) the irrelevance to most invertebrates of the proposed activity-based biological indicators for endocrine disruptor exposure (androgen, estrogen and thyroid); (4) limited field studies. Past and ongoing research efforts using the standard invertebrate toxicity test model, the mysid shrimp, have aimed at addressing some of these issues. The present review serves as an update to a previous publication on the use of mysid shrimp for the evaluation of endocrine disruptors (Verslycke et al., 2004a). It summarizes recent investigative efforts that have significantly advanced our understanding of invertebrate-specific endocrine toxicity, population modeling, field studies, and transgeneration standard test development using the mysid model.

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“…An environmental endocrine disrupting chemical (EDC) known as 4-nonylphenol (NP) is suggested to have high estrogenic potency (Noppe et al, 2005), and it is known to interfere with normal vitellogenesis (Ghekierea et al, 2006;Hannas et al, 2011;Ara and Damrongphol, 2012). Generally, estrogen exposure in crustaceans can induce Vtg expression (Atienzar et al, 2002;Vandenbergh et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro inhibitory action of 17β-estradiol and environmental estrogen 4-nonylphenol on gonad-inhibiting hormone (GIH) expression in the eyestalks of Litopenaeus vannamei

Chen

Deng

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The gonad-inhibiting hormone (GIH) belongs to a neuropeptide family synthesized and released in an X-organ sinus gland complex of crustacean eyestalks. GIH inhibits crustacean ovarian maturation by suppressing vitellogenin (Vtg) synthesis, whereas estrogen is responsible for the stimulation of vitellogenesis (not established). In this study, the effects of 17β-estradiol (E 2 , 10 -6 M), estrogen receptor antagonist tamoxifen (TAM, 10 -6 , 10 -7 , and 10 -8 M), and the environmental estrogen nonylphenol (NP, 1 μg/L and 100 μg/L) on LvGIH expression in the eyestalks of shrimp were determined by quantitative real-time PCR. Results showed that LvGIH expression decreased significantly during the L. vannamei ovarian maturation cycle. E 2 and NP significantly reduced LvGIH transcripts in 14057 GIH expression with estrogen treatment in L. vannamei ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 14056-14065 (2015) vivo, but TAM neutralized the inhibitory action of E 2 in a dose-dependent manner (P < 0.05). In addition, the LvGIH expression levels decreased significantly in a time-dependent manner (P < 0.05) when ovary fragments were cultured in vitro with E 2 . The results of this study suggested that estrogen regulates GIH expression in L. vannamei eyestalks. E 2 promoted ovarian development not only by directly upregulating vitellogenesis in the hepatopancreas, but it was also capable of downregulating LvGIH expression, which indirectly resulted in the stimulation of L. vannamei vitellogenesis.

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Effects of 17α-ethinylestradiol on sexual development of the amphipod Hyalella azteca

Cited by 70 publications

References 28 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Mysid crustaceans as standard models for the screening and testing of endocrine-disrupting chemicals

In vivo and in vitro inhibitory action of 17β-estradiol and environmental estrogen 4-nonylphenol on gonad-inhibiting hormone (GIH) expression in the eyestalks of Litopenaeus vannamei

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