Effects of 4-tert-octylphenol given in drinking water for 4 months on the male reproductive system of Fischer 344 rats

Blake, Charles A.; Boockfor, Fredric R.; Nair-Menon, Joyce; Millette, Clarke F.; Raychoudhury, Samir S.; McCoy, George L.

doi:10.1016/j.reprotox.2003.09.003

Cited by 42 publications

(14 citation statements)

References 24 publications

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“…Consumption of water containing OP for 4 months at concentrations of approximately 50-fold lower than that which has been measured in water in the environment caused an increased incidence of tail abnormalities in epididymal sperm (Blake et al, 2004). It has been reported that NP may directly influence the flagellar structure of a motile alga in culture (Weinberger and Rea, 1981).…”

Section: Discussionmentioning

confidence: 99%

Pro-oxidant effect of vitamin C coadministration with bisphenol A, nonylphenol, and octylphenol on the reproductive tract of male rats

Aydoğan

Korkmaz

Barlas

et al. 2009

Drug and Chemical Toxicology

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This study was performed to investigate whether bisphenol A (BPA), nonylphenol (NP), and octylphenol (OP) induce oxidative stress on the reproductive tract of male rats and if coadministration of vitamin C can prevent any possible oxidative stress. Wistar male rats were divided into seven groups as control (vehicle; olive oil), BPA, NP, OP, BPA+C, NP+C, and OP+C. BPA, OP, and NP groups (25 mg/kg/day) were administered orally to rats three times a week for 45 days. In BPA+C, NP+C, and OP+C groups, vitamin C (60 mg/kg/day) was administered orally along with BPA, OP, and NP (25 mg/kg/day) treatments. Malondialdehyde (MDA) appeared at significantly higher concentrations in BPA-, NP-, and OP-treated groups, when compared to control group. No significant decrease was observed in testes MDA levels of vitamin C coadministrated groups, compared with BPA, NP, and OP treatment groups. Decreased levels of reduced glutathione (GSH) were found in testes of BPA-, NP-, OP-treated rats. No significant increase was observed in testes GSH levels of BPA+C, NP+C, and OP+C groups, compared with BPA, NP, and OP treatment groups. Histological examination showed that vitamin C coadministrated groups had much more congestion areas, atrophy, and germinal cell debris in testes than those observed in other groups. Abnormal sperm percentages of BPA, BPA+C, NP+C, and OP+C groups were increased. In conclusion, the present results demonstrated that BPA, NP, and OP generate reactive oxygen species that cause oxidative damage in testes of rats. Coadministration of vitamin C aggravates this damage.

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Section: Discussionmentioning

confidence: 99%

Pro-oxidant effect of vitamin C coadministration with bisphenol A, nonylphenol, and octylphenol on the reproductive tract of male rats

Aydoğan

Korkmaz

Barlas

et al. 2009

Drug and Chemical Toxicology

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“…Exposure to OP is a matter of concern because it has been shown to be estrogenic and has the potential to interfere with normal endocrine function through human estrogen receptors [7]. Toxicological studies have consistently reported associations between exposure to OPs and impaired health, including adverse effects on male reproduction [8]–[10]. 2,3,4-Trichlorophenol (2,3,4-TCP) and 2,4,5-Trichlorophenol (2,4,5-TCP) are important representatives of chlorinated organic compounds.…”

Section: Introductionmentioning

confidence: 99%

Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility

Qin

Chen

et al. 2013

PLoS ONE

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Octylphenol (OP) and Trichlorophenol (TCP) act as endocrine disruptors and have effects on male reproductive function. We studied the interactions between 4-tert-Octylphenol (4-t-OP), 4-n- Octylphenol (4-n-OP), 2,3,4-Trichlorophenol (2,3,4-TCP), 2,4,5-Trichlorophenol (2,4,5-TCP) urinary exposure levels and polymorphisms in selected xenobiotic metabolism enzyme genes among 589 idiopathic male infertile patients and 396 controls in a Han-Chinese population. Ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to measure alkylphenols and chlorophenols in urine. Polymorphisms were genotyped using the SNPstream platform and the Taqman method. Among four phenols that were detected, we found that only exposure to 4-t-OP increased the risk of male infertility (P trend = 1.70×10−7). The strongest interaction was between 4-t-OP and rs4918758 in CYP2C9 (P inter = 6.05×10−7). It presented a significant monotonic increase in risk estimates for male infertility with increasing 4-t-OP exposure levels among men with TC/CC genotype (low level compared with non-exposed, odds ratio (OR) = 2.26, 95% confidence intervals (CI) = 1.06, 4.83; high level compared with non-exposed, OR = 9.22, 95% CI = 2.78, 30.59), but no associations observed among men with TT genotype. We also found interactions between 4-t-OP and rs4986894 in CYP2C19, and between rs1048943 in CYP1A1, on male infertile risk (P inter = 8.09×10−7, P inter = 3.73×10−4, respectively).We observed notable interactions between 4-t-OP exposure and metabolism enzyme gene polymorphisms on idiopathic infertility in Han-Chinese men.

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“…An example is the alkylphenolic pollutant, 4- tert -octylphenol (OP) (Sharma et al, 2009; Ying et al, 2002) that is detected in the plasma and adipose tissue within human populations (Calafat et al, 2008; Inoue et al, 2000; Lopez-Espinosa et al, 2009; Ying et al, 2002). Across a wider range of vertebrate species the observed biological effects of OP exposure are multifold and may include altered gene and/or protein expression in gonadal and pituitary tissues (Lee et al, 2006; Majdic et al, 1997; Mayer et al, 2003; Rhee et al, 2009), abnormal steroid production (Mikkila et al, 2006; Myllymaki et al, 2005b), sperm abnormalities, changes in testicular function (Herath et al, 2004; Kinnberg and Toft, 2003; Rey et al, 2009;) Blake et al, 2004), and impaired sexual differentiation and fertility (Rasmussen et al, 2002; Seki et al, 2003; Karels et al, 2003). Thus, investigation of the biological outcome following treatment of a sentinel species with OP represents a useful model for exposure to estrogenic substances prevalent within the environment.…”

Section: Introductionmentioning

confidence: 99%

Estrogenic environmental contaminants alter the mRNA abundance profiles of genes involved in gonadal differentiation of the American bullfrog

Wolff

Veldhoen

Helbing

et al. 2015

Science of The Total Environment

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Wildlife and human populations are exposed to anthropogenic mixtures of chemicals in the environment that may adversely influence normal reproductive function and development. We determined the effects of exposure to estrogenic chemicals and wastewater effluent (WWE) on developing gonads of the American bullfrog, Rana (Lithobates) catesbeiana, a species whose widespread distribution make it an ideal model for environmental monitoring for endocrine effects of chemical contaminants. Premetamorphic bullfrog tadpoles were exposed to treatment vehicle, 17β-estradiol (E2; 10−9 M) or 4-tert-octylphenol (OP; 10−9 M, 10−8 M, and 10−7 M). Additionally, gonadal differentiation was evaluated in bullfrog tadpoles from a WWE-containing site versus those from a reference location receiving no WWE. In both studies, phenotypic sex, steroidogenic factor-1 (nr5a1), and aromatase (cyp19a1) mRNA levels using quantitative real-time PCR were determined. Exposure to E2 or OP did not alter sex ratios. In controls, both nr5a1 and cyp19a1 transcript levels exhibited sexual dimorphism, with males demonstrating higher levels of nr5a1 and females greater abundance of cyp19a1. However, E2 exposure increased cyp19a1 mRNA abundance in testes and decreased levels in ovaries, eliminating the sexual dimorphism observed in controls. E2-exposed males exhibited increased nr5a1 transcript levels in the testes compared to controls, while females demonstrated no E2 effect. OP treatment had no effect on female cyp19a1 mRNA abundance, but exposure to 10−7 M OP increased testicular transcript levels. Treatment with 10−9 and 10−8 M OP, but not 10−7 M, resulted in decreased abundance of nr5a1 transcript in both ovaries and testes. Animals from the field had sexually dimorphic gonadal levels of cyp19a1, but both sexes from the WWE site exhibited elevated cyp19a1 transcript abundance compared to the reference location. Individual chemical compounds and anthropogenic wastewater effluent dispersed within the environment influence the levels of gonadal mRNA encoding key proteins involved in gonadal differentiation.

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Effects of 4-tert-octylphenol given in drinking water for 4 months on the male reproductive system of Fischer 344 rats

Cited by 42 publications

References 24 publications

Pro-oxidant effect of vitamin C coadministration with bisphenol A, nonylphenol, and octylphenol on the reproductive tract of male rats

Pro-oxidant effect of vitamin C coadministration with bisphenol A, nonylphenol, and octylphenol on the reproductive tract of male rats

Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility

Estrogenic environmental contaminants alter the mRNA abundance profiles of genes involved in gonadal differentiation of the American bullfrog

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