Effects of 900-MHz Microwave Radiation on γ-Ray-Induced Damage to Mouse Hematopoietic System

Induction of adaptive response: Pre-exposure of mice to 900 MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionising radiation

“…The results from our earlier investigation have suggested that pre-treatment of mice with 900 MHz RF significantly reduced the hematopoietic tissue damage induced by subsequent exposure to gamma-radiation (Meng et al 2007, Cao et al 2010. The data obtained in the present study confirmed these observations and further suggested that the 120 mW/cm 2 power intensity for 900 MHz RF preexposure was adequate and optimum to lead to the maximum protection of hematopoietic tissue damage induced by subsequent exposure to gamma-radiation.…”

“…The RF field inside the GTEM was probed using a field strength meter (PMM, Cisano sul Neva, Italy) to determine the precise positions which provided power intensities of 12, 120 or 1,200 mW/cm 2 . The system power was monitored and recorded using a computer controlled data logging system (Figures 1A and 1B;Cao et al 2010). Small plastic boxes were designed in-house to hold mice (a single restrained mouse in each box).…”

“…The results from our previous investigations have indicated that pre-exposure of mice to 900 MHz RF at 120 mW/cm 2 power intensity increased the survival and significantly reduced the hematopoietic tissue damage induced by subsequent exposure to gammaradiation (Meng et al 2007, Cao et al 2010. The objectives of the current investigations are to: (a) Confirm the earlier observations, (b) determine the optimal power intensity needed for RF pre-exposure in order to achieve considerable 'protection' from subsequent ionising radiation-induced damage, and (c) explore potential mechanism(s) involved.…”

Modifying effects of low-intensity extremely high-frequency electromagnetic radiation on content and composition of fatty acids in thymus of mice exposed to X-rays

“…A reduction of the growth rate of breast cancer xenografts, retarding tumor vascularization and metastasis in mice exposed to therapeutic EMF (15 mT amplitude, 120 pulses per second) and γ-radiation (total dose of 8 Gy) compared with γ-radiation therapy alone was found (Cameron et al 2005). Pre-exposure of mice to 900-MHz RF EMF (0.12 mW/cm 2 , average whole-body SAR of about 54.8 mW/kg) for 1 h/day for 14 days attenuated the damage produced by γ-rays as evidenced by a significant increase in survival time (after 8 Gy γirradiation) and less severe pathological alterations in bone marrow and spleen (after 5 Gy γirradiation) (Cao et al 2010(Cao et al , 2011. Pre-exposure of mice to 900-MHz RF EMF (0.12 mW/cm 2 ) for 4 h/day for 3, 5, 7, and 14 days significantly decreased DNA damage in peripheral blood leukocytes (Jiang et al 2012) and micronuclei formation in immature erythrocytes in peripheral blood and bone marrow (Jiang et al 2013) induced by exposure to γ-rays at a dose of 3 Gy.…”

Mobile Phones, Non-Ionizing Radiofrequency Fields and Brain Cancer: Is There an Adaptive Response?

“…Several recent reports published in peer reviewed scientific journals indicated that non-ionizing RF exposure was capable of inducing AR: (i) human blood lymphocytes exposed in vitro to RF (AD) and then treated with a high dose of a chemical mutagen or ionizing radiation (CD) exhibited significantly decreased genetic damage (Sannino et al 2009;Sannino et al 2011;Zeni et al 2012;Sannino et al 2013), (ii) continuously growing human tumor cells exposed to RF and then treated with a chemotherapeutic drug showed significantly increased viability, decreased apoptosis, and several other biological endpoints indicating protective influence of RF exposure (Jin et al 2012) and (iii) mice and rats exposed (whole body) to RF and subsequently subjected to sub-lethal and lethal doses of ionizing radiation showed significant survival advantage, less severe hematopoietic tissue damage, decreased genetic damage in blood and bone marrow cells, increased levels of colony stimulating factor and interleukin-3 in the serum and increased expression of genes related to cell cycle, etc. (Cao et al 2010(Cao et al , 2011Jiang et al 2012Jiang et al , 2013Mortazavi et al 2011Mortazavi et al , 2012Mortazavi et al , 2013Haghani et al 2013). Thus, the results in these reports also provided some mechanistic evidence for RF-induced AR and several others were proposed (Vijayalaxmi et al 2014).…”