Effects of a bioactive glass on healing of closed skin wounds in dogs

Gillette, Robert; Swaim, Steven F.; Sartin, Eva A.; Bradley, Dino; Coolman, Shindok L.

doi:10.2460/ajvr.2001.62.1149

Cited by 41 publications

(33 citation statements)

References 8 publications

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“…In one previous clinical study, the authors reported a poor healing 4 months after femtosecond assisted top-hat keratoplasty, requiring new sutures [25]. By contrast, in vitro studies have shown that glass particles may increase skin wound healing and subcutaneous breaking strength in dogs, by activating fibroblasts and myofibroblasts proliferation and migration [26].…”

Section: Discussionmentioning

confidence: 96%

Deposit of glass fragments during femtosecond laser penetrating keratoplasty

Nuzzo

Plamann

Savoldelli

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 96%

Deposit of glass fragments during femtosecond laser penetrating keratoplasty

Nuzzo

Plamann

Savoldelli

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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“…Understanding the mechanisms responsible for clinical success of the borate nanofibers should lead to many new applications in soft tissue repair and regeneration. Studies have also shown that small powders of 45S5 silicate-based glass can also be effective in accelerated wound healing [25]. [26] Understanding the effect of bioactive stimuli on angiogenesis offers the potential for designing a wide range of new applications, including cardiovascular repair [27][28][29].…”

Section: Soft Connective Tissue Repair and Regenerationmentioning

confidence: 99%

The future of bioactive ceramics

Hench

2015

J Mater Sci: Mater Med

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Two important worldwide needs must be satisfied in the future; (1) treatment of the deteriorating health of an aging population and, (2) decreasing healthcare costs to meet the needs of an increased population. The ethical and economic dilemma is how to achieve equality in quality of care while at the same time decreasing cost of care for an ever-expanding number of people. The limited lifetime of prosthetic devices made from first-generation nearly inert biomaterials requires new approaches to meet these two large needs. This paper advises an expanded emphasis on: (1) regeneration of tissues and (2) prevention of tissue deterioration to meet this growing need. Innovative use of bioactive ceramics with genetic control of in situ tissue responses offers the potential to achieve both tissue regeneration and prevention. Clinical success of use of bioactive glass for bone regeneration is evidence that this concept works. Likewise the use of micron sized bioactive glass powders in a dentifrice for re-mineralization of teeth provides evidence that prevention of tissue deterioration is also possible. This opinion paper outlines clinical needs that could be met by innovative use of bioactive glasses and ceramics in the near future; including: regeneration of skeletal tissues that is patient specific and genetic based, load-bearing bioactive glass-ceramics for skeletal and ligament and tendon repair, repair and regeneration of soft tissues, and rapid low-cost analysis of human cell-biomaterial interactions leading to patient specific diagnoses and treatments using molecularly tailored bioceramics.

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“…Quickly mixed with blood, they could thus prevent large blood loss. Their positive impact onto wound healing also has been shown by applying micron sized bioactive glass particles into open wounds before sewing them: with no increase in inflammatory reaction compared to control wounds, newly formed subcutaneous tissues presented higher breaking strength [79]. Studies have also shown the impact of bioactive glass particles design.…”

Section: Materials Design For Biomedical Applicationsmentioning

confidence: 99%

Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications

2016

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Thanks to their high biocompatibility and bioactivity, bioactive glasses are very promising materials for soft and hard tissue repair and engineering. Because bioactivity and specific surface area intrinsically linked, the last decade has seen a focus on the development of highly porous and/or nano-sized materials. This review emphasizes the synthesis of bioactive glass nanoparticles and materials design strategies. The first part comprehensively covers mainly soft chemistry processes, which aim to obtain dispersible and monodispersed nanoparticles. The second part discusses the use of bioactive glass nanoparticles for medical applications, highlighting the design of materials. Mesoporous nanoparticles for drug delivery, injectable systems and scaffolds consisting of bioactive glass nanoparticles dispersed in a polymer, implant coatings and particle dispersions will be presented.

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Effects of a bioactive glass on healing of closed skin wounds in dogs

Cited by 41 publications

References 8 publications

Deposit of glass fragments during femtosecond laser penetrating keratoplasty

Deposit of glass fragments during femtosecond laser penetrating keratoplasty

The future of bioactive ceramics

Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications

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