Effects of a Bradykinin Receptor Antagonist (HOE140) on Taurocholate-Induced Acute Pancreatitis in Rats

Kinin-B1 Receptors in Ischaemia-Induced Pancreatitis: Functional Importance and Cellular Localisation

“…Moreover, in contrast to protective effects observed by our group and others in previous studies using only a kinin-B2 receptor antagonist, we observed that the combined kinin B1 and B2 receptor antagonists did not show any beneficial effects (Hoffmann et al, 1996c;Kanbe et al, 1996). This deleterious effect was independent of the significantly reduced leukocyteendothelium interaction.…”

“…Therefore, as soon as there were sufficient data to show that kinin-B1 antagonism would not benefit patients suffering from acute pancreatitis, either alone or in combination with kinin-B2 receptor antagonism, we stopped the experiments. It should also be noted that several authors have described a survival benefit of kinin-B2 receptor antagonism in models of acute pancreatitis (Kanbe et al, 1996;Satake et al, 1996;Yekebas et al, 2000). In our experiments the combined antagonism of both kinin receptors not only did not show any beneficial effects, but in fact decreased the survival rate.…”

“…The activation of platelets, an important step in coagulation, is also influenced by kinin-B1 receptor antagonism. Furthermore, the application of a selective kinin-B2 receptor antagonist was shown to have a protective effect on the pancreas in different models of acute pancreatitis (Griesbacher et al, 1995;Kanbe et al, 1996;Asano et al, 1997;Hoffmann et al, 1997;Bloechle et al, 1998). There was an improvement in the microcirculation, less oedema, the amylase levels within the pancreas were reduced, and the survival rate increased.…”

“…During ischaemia/reperfusion studies in experimental pancreatitis, antagonism of the kinin-B2 receptors has been shown to exhibit a protective effect (Closa et al, 1995;Hoffmann et al, 1996bHoffmann et al, ,c, 1997Kanbe et al, 1996). The question whether kinin-B1 receptors serve a functionally important role in pancreatitis has not been investigated.…”

Galanin Receptor Antagonist M35 but Not M40 or C7 Ameliorates Cerulein-Induced Acute Pancreatitis in Mice

“…Bradykinin has numerous pro-inflammatory properties [34] and blockade of the bradykinin-1 receptor reduces the severity of AP [35,36]. By analogy with the discussion above relating to galantide, M35 could act as a bradykinin antagonist to ameliorate AP, which is consistent with our data.…”