Effects of a Combined Exercise Training Program on Health Indicators and Quality of Life of People Living with HIV: A Randomized Clinical Trial

Oliveira, Vitor H F; Rosa, Francisco Dalla; Santos, Jádia C; Wiechmann, Susana Lílian; Narciso, Argéria Maria Serraglio; Moraes, Solange Marta Franzói de; Webel, Allison R.; Deminice, Rafael

doi:10.1007/s10461-019-02678-3

Cited by 18 publications

(73 citation statements)

References 41 publications

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“…We carried out searches sequentially using the three primary outcomes (symptoms of depression, physical activity level and social participation) in the search strategy. The initial search yielded 3530 potential citations of which thirteen publications (43,(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61) were considered eligible to be included in the review. (Figure 1) review.…”

Section: Results Search Resultsmentioning

confidence: 99%

“…(Figure 1) review. This review included ve publications on depression (43,50,53,56,60), seven publications on social participation/functioning (51,52,55,56,58,59,61) and two publications on PAL (54,57). All the studies included in this review were conducted in the post-HAART era.…”

Section: Results Search Resultsmentioning

confidence: 99%

“…Nevertheless, four studies (51, 53, 54) did not report the ART status of the participants. Similarly, ten studies did not report the staging of HIV in the participants (43,(52)(53)(54)(55)(56)(57)(58)(59)61). In contrast, two studies (50,60) reported that the participants' disease staging was category A and B" according to the US Centre for Disease Control classi cation of HIV infection or "asymptomatic, non-AIDS and symptomatic, non-AIDS stages', respectively.…”

Section: Participants Of the Included Studiesmentioning

confidence: 99%

“…i. Depression: A total of 279 participants were included in the ve publications (43,50,53,56,60) that investigated the effects of physical exercises on depression ( Table 1). On completion of the study, only 205 (73.48%) participants were retained while 74 (26.52%) participants withdrew.…”

Section: Participants Of the Included Studiesmentioning

confidence: 99%

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Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: A systematic review and meta-analysis

Ibeneme

Uwakwe

Myezwa

et al. 2020

Preprint

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Background: Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: What is the extent to which physical exercise training affected symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of interventions, usual care, or no treatment controls? Objectives: To assess the impact of physical exercise training on symptoms of depression, PAL and social participation in PLWHA. Data sources: Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Study eligibility criteria: Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Data collection and analysis: Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results: Thirteen studies met the inclusion criteria with 779 participants (n=596 participants on study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18-86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2-3 times/week, at 40-60 minutes/session, and for between 6-24 weeks, and the risk of bias varied from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD=-0.74, 95% confidence interval (CI)=-1.01,-0.48,p=<0.0002;I2=47%;5studies; 205participants) unlike PAL (SMD=0.98,95%CI=-0.25,2.17,p=0.11;I2=82%;2studies;62 participants) and social participation (SMD=0.04,95%CI=-0.65,0.73,p=0.91;I2=90%; 6 studies; 373 participants).Conclusion: Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect their PAL and social participation. However, the high heterogeneity in the included studies, imply that adequately powered RCTs with clinical/methodological similarity are required in future studies.Registration number: INPLASY202040048

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Section: Results Search Resultsmentioning

confidence: 99%

Section: Results Search Resultsmentioning

confidence: 99%

Section: Participants Of the Included Studiesmentioning

confidence: 99%

Section: Participants Of the Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: A systematic review and meta-analysis

Ibeneme

Uwakwe

Myezwa

et al. 2020

Preprint

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“…Regular exercise has been beneficial in addressing mental health issues and psychological functioning in PLHIV [13]. Aerobic exercise has the capacity to reduce the severity of depression while a combination of aerobic and resistance exercise can decrease anxiety levels considerably in PLHIV [14,15].…”

Section: Introductionmentioning

confidence: 99%

Physical activity and exercise for older people living with HIV: a protocol for a scoping review

2020

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Background: Older people living with HIV (OPLWH) are expected to live longer in the era of antiretroviral treatment, but at the same time, they are at risk for developing various health complications as a consequence of a life with the infection, exposure to medications that carry their own toxicity and side effects, and the natural effects of aging on the immune system. Because senescence is an inherent process that can be accelerated by HIV, it is important to identify strategies that can modify this phenomenon. Emerging data suggests that while physical activity and exercise may not have a positive impact on viral replication and on the immune system of people living with HIV, it can elicit improvements in cardiorespiratory fitness, strength, body composition, and overall quality of life. The purpose of this study is to map out empirical evidence on the effects of physical activity and exercise in OPLWH. Methods: The scoping review methods will be guided by the framework proposed by the Joanna Briggs Institute guidelines. Literature searches will be conducted in the following electronic databases (from inception onwards): PubMed/MEDLINE, Cochrane Library, and Google Scholar. Peer-reviewed journal papers will be included if they are written in English, involved human participants aged 50 years, and older with HIV and described a measure for physical, mental, or functional status of physical activity/exercise and/or the recommendations in OPLWH. Quantitative, qualitative, and mixed-method studies will be included in order to consider different aspects of measuring the effects of physical activity and exercise (e.g., quality of life, functional status, activities of daily living). Two reviewers will screen all citations and full-text articles. We will abstract data, organize them into themes and sub-themes, summarize them, and report the results using a narrative synthesis. The study methodological quality (or bias) will be appraised using a Mixed Methods Appraisal Tool. Discussion: The evidence gathered from the selected studies will be discussed in relation to the research questions using a narrative to identify and explore emergent themes. The review will provide a baseline of evidence on exercise and physical activity interventions for OPLWH. It will highlight gaps regarding the use of exercise and physical activity and contribute to the design of an effective intervention approach to the rehabilitation of OPLWH. Systematic review registration: Open Science Framework (https://osf.io/728kp/).

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Combined training improves the diagnostic measures of sarcopenia and decreases the inflammation in HIV‐infected individuals

Ghayomzadeh

Hackett

SeyedAlinaghi

et al. 2022

J cachexia sarcopenia muscle

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Background HIV‐related sarcopenia is an emerging health issue that often remains undiagnosed and can lead to reduced quality of life, independence, and premature death if untreated. This study investigated the effects of a 6 month combined training (resistance plus aerobic exercise) (CT) intervention on diagnostic measures of sarcopenia, including grip strength, appendicular lean mass index (ALMI), and gait speed. Methods Forty participants were randomized into either a CT group (n = 20; age = 38.3 ± 4.9 years) or a control group (CON; n = 20; age = 37.9 ± 5.1 years). Participants in the CT group performed three supervised sessions per week for 6 months, consisting of weekly reverse linear periodized resistance training followed by 20 min aerobic training. Participants in the CON group were instructed to continue with their current lifestyle habits. Assessments were completed at baseline and after 6 months. Statistical analyses were performed using a two‐way analysis of covariance (ANCOVA) adjusted for sex and preintervention values. Primary outcomes included grip strength, ALMI, and gait speed. Secondary outcomes were changes in levels of pro‐inflammatory cytokines (IL‐6 and TNF‐α), IGF‐1, and myostatin. Associations were explored between changes in inflammatory markers (IL‐6 and TNF‐α), gait speed, and ALMI with grip strength. Results A significant increase in ALMI was found for CT compared with CON (0.29 ± 0.13 kg/m2 vs. −0.11 ± 0.14 kg/m2, respectively; P < 0.001). Significant improvements in grip strength (7.86 ± 8.50 kg for CT vs. −1.58 ± 2.47 kg for CON) and gait speed (0.16 ± 0.07 m/s2 for CT vs. −0.06 ± 0.52 m/s2 for CON; both P < 0.001) were also observed in CT compared with CON. Reduction in inflammatory biomarkers was found in CT compared with CON (IL‐6; TNF‐α, both P < 0.001). An increase in IGF‐1 (74.36 ± 56.64 pg/mm3 for CT vs. 7.19 ± 99 pg/mm3 for CON; P < 0.001) and a decrease in myostatin (−158.90 ± 62.03 pg/mm3 for CT vs. −43.33 ± 146.60 pg/mm3 for CON; P < 0.001) was found following CT compared with the CON group. Change in grip strength was correlated with changes in IL‐6 (r = −0.65, P < 0.001), TNF‐α (r = −0.63, P < 0.001), gait speed (r = 0.63, P < 0.001), and ALMI (r = 0.54, P = 0.001), but not IGF‐1 and myostatin. No adverse events were recorded, and compliance with the CT exercise sessions was high (>85%). Conclusions Combined training appears to be an effective means to counteract sarcopenia and improve various inflammatory markers and growth hormones in people living with HIV.

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Effects of a Combined Exercise Training Program on Health Indicators and Quality of Life of People Living with HIV: A Randomized Clinical Trial

Cited by 18 publications

References 41 publications

Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: A systematic review and meta-analysis

Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: A systematic review and meta-analysis

Physical activity and exercise for older people living with HIV: a protocol for a scoping review

Combined training improves the diagnostic measures of sarcopenia and decreases the inflammation in HIV‐infected individuals

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