Effects of a commercially available vaccine against Salmonella enterica serotype Newport on milk production, somatic cell count, and shedding of Salmonella organisms in female dairy cattle with no clinical signs of salmonellosis

Hermesch, D. R.; Thomson, Daniel U.; Loneragan, Guy H.; Renter, David G.; White, Brad J.

doi:10.2460/ajvr.69.9.1229

Cited by 37 publications

(31 citation statements)

References 12 publications

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“…This is a subunit component vaccine under conditional license, and it contains purified outer membrane proteins from S. Newport. This vaccine formulation has been shown to induce antibody production in cattle; however, no significant difference in fecal shedding of Salmonella or symptoms of disease were observed between vaccinated and unvaccinated groups (56,57). Surprisingly, it was observed that vaccinated cattle produced more milk than unvaccinated cattle, although the mechanism for this remains unclear (56).…”

Section: Vaccines Against Serogroup C Ntsmentioning

confidence: 78%

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Fuche

Sow

Simon

et al. 2016

Clin Vaccine Immunol

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Section: Vaccines Against Serogroup C Ntsmentioning

confidence: 78%

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Fuche

Sow

Simon

et al. 2016

Clin Vaccine Immunol

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“…Administration of S. Newport vaccine in cattle may further help in controlling infections in dairy herds. It will also check environmental dissemination of S. Newport by controlling faecal shedding into the environment26. No specific trends were observed in the number of the S. Newport isolates from various parts of the country.…”

Section: Discussionmentioning

confidence: 99%

Distribution trends & antibiogram pattern of Salmonella enterica serovar Newport in India

Kumar¹,

Gupta²,

Vaish³

et al. 2016

Indian Journal of Medical Research

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Background & objectives:Salmonellosis is a major public health concern worldwide. Besides typhoidal salmonellae, infections due to non-typhoidal serovars of Salmonella are also associated with high morbidity and mortality leading to huge economic losses. Among non-typhoidal serovars, Salmonella Newport has been reported as a major cause of foodborne infections resulting in outbreaks due to consumption of contaminated food items. Little data related to this serovar are available from India leading to the scarcity of information on the distribution trends of this important serovar in the country. Therefore, an effort was made in the present study to generate data on distribution trends and antibiogram of S. Newport in the country.Methods:S. Newport isolates received at the National Salmonella and Escherichia Centre at Kasauli, India, during January 2010 to December 2013 were analysed for their distribution trends and antibiogram data were also generated using standard methods.Results:In the present study, S. Newport isolates were received from eight States and one union territory of the country and highest proportion of S. Newport isolates were found to be from humans (53.61%) followed by animals (27.84%) and food (18.56%). S. Newport isolates exhibited resistance to all drugs used in the present study except chloramphenicol, ciprofloxacin and cefuroxime.Interpretation & conclusions:Considering distribution of this important serovar of Salmonalla and its wide range of reservoirs, steps towards formulation and execution of efficient surveillance programmes should be taken.

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“…In the US, the economic impact of Salmonella infection is substantial and periodic multi-state outbreaks of gastroenteritis occur due to the ingestion of contaminated produce, meat, or processed foods (3). Public health measures have improved food handling and limited the dissemination of livestock waste, while vaccines have also been developed to reduce Salmonella carriage in livestock and poultry (4, 5). Despite these efforts, Salmonella infections cause over 1 million illnesses in the US every year (6).…”

Section: Introductionmentioning

confidence: 99%

Dual Immunization with SseB/Flagellin Provides Enhanced Protection against Salmonella Infection Mediated by Circulating Memory Cells

Lee

Benoun

Sheridan

et al. 2017

The Journal of Immunology

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The development of a sub-unit Salmonella vaccine has been hindered by the absence of detailed information about antigenic targets of protective Salmonella-specific T and B cells. Recent studies have identified SseB as a modestly protective antigen in susceptible C57BL/6 mice, but the mechanism of protective immunity remains undefined. Here, we report that simply combining Salmonella SseB with flagellin substantially enhances protective immunity, allowing immunized C57BL/6 mice to survive for up to 30 days following challenge with virulent bacteria. Surprisingly, the enhancing effect of flagellin did not require flagellin antigen targeting during secondary responses or recognition of flagellin by TLR5. While co-immunization with flagellin did not affect SseB-specific antibody responses, it modestly boosted CD4 responses. In addition, protective immunity was effectively transferred in circulation to parabionts of immunized mice, demonstrating that tissue resident memory is not required for vaccine-induced protection. Finally, protective immunity required host expression of IFN-γR but was independent of iNOS expression. Taken together, these data indicate that Salmonella flagellin has unique adjuvant properties that improve SseB-mediated protective immunity provided by circulating memory.

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Effects of a commercially available vaccine against Salmonella enterica serotype Newport on milk production, somatic cell count, and shedding of Salmonella organisms in female dairy cattle with no clinical signs of salmonellosis

Cited by 37 publications

References 12 publications

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Distribution trends & antibiogram pattern of Salmonella enterica serovar Newport in India

Dual Immunization with SseB/Flagellin Provides Enhanced Protection against Salmonella Infection Mediated by Circulating Memory Cells

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