Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model

Gosslau, Alexander; Zachariah, Emmanuel; Li, Shiming; Ho, Chi‐Tang

doi:10.1016/j.fshw.2018.10.001

Cited by 15 publications

(14 citation statements)

References 46 publications

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“…In the 3T3 preadipocyte model, an inhibition of NFκB signaling corresponded to a suppression of adipogenesis by quercetin-induced apoptosis, mediated through decreased phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) (Ahn et al, 2008). These studies are in agreement with our recent study which showed strong anti-inflammatory effects of an orange peel extract enriched with flavonoids in an obese rat model for type 2 diabetes (Gosslau et al, 2018).…”

Section: Mechanism Experimental Model Referencesupporting

confidence: 89%

“…Our studies have shown significant anti-inflammatory effects of flavonoid-enriched orange peel extracts as validated in cell-based and in vivo models for inflammation (Gosslau et al, 2014;Gosslau et al, 2011;Gosslau et al, 2018;Lai et al, 2015;Li et al, 2007;Sergeev et al, 2007;Wang et al, 2016). Chronic inflammation is also a key pathologic link between obesity and type 2 diabetes (T2D).…”

Section: Therapeutic Effects Of Citrus Fruit Polyphenolic Flavonoids mentioning

confidence: 76%

“…It is generally believed that antioxidant and anti-inflammatory activities are the main underlying mechanisms for the health-promoting effects of PHFs and PMFs. In light of the beneficial effects of PHFs and PMFs as main bioactives of citrus fruits, we noted strong effects of hydroxylated PMFs (OH-PMFs) against disorders related to chronic inflammation such as diabetes and cancer (Gosslau et al, 2011;Gosslau et al, 2018;Lai et al, 2011).…”

Section: Therapeutic Effects Of Citrus Fruit Polyphenolic Flavonoids mentioning

confidence: 99%

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The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

Gosslau¹,

Ho²,

Li³

2019

Journal of Food Bioactives

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Chronic inflammation and dysregulation of apoptotic pathways leading to free radical-induced tissue damage are widely recognized as major underlying causes of major degenerative diseases, including cancer, diabetes, neurological and cardiovascular disorders. Citrus fruits are rich sources of polyphenolic flavonoids well known for their wide range of pharmacological properties. Rutin (quercetin-3-O-rutinoside) and diosmin (diosmetin 7-Orutinoside) are two major polyhydroxyflavone glycosides abundantly found in citrus peels and, to a lesser extent, in pulp of a variety of different citrus species. During digestion, hydrolysis by intestinal enzymes and gut microbiota lead to the release of their corresponding bioactive aglycones (e.g., quercetin or diosmetin). Data obtained in cell-based, animal and clinical studies demonstrated strong preventive and/or therapeutic effects of rutin and its aglycone flavone quercetin. Although lesser studies available, our recent literature review suggests diosmin as promising citrus fruit polyhydroxyflavonoids, effective against various diseases associated with chronic inflammation.

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Section: Mechanism Experimental Model Referencesupporting

confidence: 89%

Section: Therapeutic Effects Of Citrus Fruit Polyphenolic Flavonoids mentioning

confidence: 76%

Section: Therapeutic Effects Of Citrus Fruit Polyphenolic Flavonoids mentioning

confidence: 99%

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The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

Gosslau¹,

Ho²,

Li³

2019

Journal of Food Bioactives

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“…Diabetes mellitus umumnya disebabkan ketidak seimbangan asupan nutrisi, salah satunya dapat menyebabkan obesitas sehingga perlu adanya produk dengan indeks glikemik rendah dan hal ini merupakan salah satu masalah kesehatan global yang paling meningkat dalam beberapa tahun terakhir (Gosslau et al, 2018). Pola makan yang tidak sehat dan dapat menjadi salah satu resiko obesitas (Santoso et al, 2018).…”

Section: Pendahuluanunclassified

Diversifikasi Produksi Susu Kedelai Berbasis Mikroalga Autotrofik Guna Meningkatkan Indeks Nutraseutikal

Fathurohman

Aprillia

Pratita

et al. 2020

J. Apl. Teknol. Pang.

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Penelitian ini bertujuan untuk meningkatkan potensi mikroalga sebagai mikroorganisme penghasil sumber protein dalam diversifikasi produk susu kedelai. Penelitian ini menggunakan rancangan uji mutu hedonik dengan lima perlakuan variasi susu kedelai (b/b) yang disubstitusi mikroalga untuk meningkatkan indeks nutraseutikal yaitu masing-masing 0,2% (produk A), 0,4% (produk B), 0,6% (produk C), 0,8% (produk D) dan 1,0 % (produk E). Diversifikasi produk terpilih diujikan kadar protein, lemak, cemaran logam dan cemaran mikroba. Hasil uji menunjukkan bahwa rerata kesukaan panelis terhadap warna, rasa, aroma, dan kekentalan produk tidak berbeda nyata (p>0,05), diversifikasi produk yang dipilih terbanyak adalah (produk B) dengan respon kesukaan sebesar 74%. Hasil analisis produk (dalam 100 ml) mengandung kadar protein 3,61%, lemak 2,54%, pH 6,69, cemaran logam timbal ≤ 0,01 mg/l, tembaga 0,98 mg/l, seng 4,07 mg/l, timah ≤ 0,01 mg/l, merkuri ≤ 0,01 mg/l dan cemaran mikroba negatif salmonella, total kapang 1,3 CFU/ml, Esherichia coli 2 APM/ml dan kenaikan kadar protein sebelum dan setelah subtritusi mirolaga sebesear 0,33%. Kesimpulannya, diversifikasi produksi susu kedelai berbasis mikroalga dapat dilakukan untuk meningkatkan indeks nutraseutikal.Diversification of Soymilk Production Based on Autotrophic Microalgae to Improve Nutraceutical IndexAbstract Research is aimed to improve potential use of microalgae as protein microorganism producer in the manufacture of soy milk products. Hedonic quality test was used in the study with five variations on the treatment of soymilk (b/b) that was substituted with microalgae i.e. 0.2% (product A), 0.4% (product B), 0.6% (product C), 0.8% (product D), and 1.0% (product E). The modified products was tested for protein, fat, metal contamination, and microbial contamination. As results, the preference index of color, taste, aroma, and thickness of the product by panelists were not exhibited significant result (p>0.05), the most chosen product were (product B) with preference index of 74%.The analysis (per 100 ml) of protein, fat, and pH was 3.61%, 2.54%, and 6.69, respectively while metal, copper, zinc, lead, and mercury contamination was detected as 0.01, 0.98, 4.07, ≤ 0.01, ≤ 0.01 mg/l, respectively. Negative microbial contamination of salmonella was detected while the total mold was exhibited as 1.3 CFU/ml and Escherichia coli as 2 APM/ml. The increase of protein level before and after substitution with microalgae was detected as 0.33%. As conclusion, diversification of soymilk production based on microalgae might able to improve nutraceutical index of products.

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“…What’s more, a flavonoid‐enriched extract from Hippophae rhamnoides seed exhibited anti‐hypertensive and anti‐obesity effects (Yang et al., 2017). Flavonoid‐enriched orange peel extract showed anti‐diabetic activity and anti‐inflammatory effects (Gosslau et al., 2018). However, the effect of flavonoid‐enriched extract from M .…”

Section: Introductionmentioning

confidence: 99%

Flavonoid‐enriched extract from Millettia speciosa Champ prevents obesity by regulating thermogenesis and lipid metabolism in high‐fat diet–induced obese C57BL/6 mice

Wang

et al. 2021

Food Science & Nutrition

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Millettia speciosa (M. speciosa) Champ is a medicinal and edible plant. The roots are rich in flavonoids, which possess multiple biological activities, including lipid‐lowering effects. This study aimed to explore the effect of flavonoid‐enriched extract from M. speciosa (FMS) on obesity. The UPLC‐Q‐TOF‐MS analysis and chromatographic analysis were adopted to identify flavonoid compounds in FMS. Male C57BL/6J mice were fed with a high‐fat diet for 3 months and were then treated with FMS (50 or 100 mg/kg/d) or Orlistat (10 mg kg−1 d−1) for another 8 weeks. A total of 35 flavonoids were identified in the extract of M. speciosa root. FMS reduced body weight gain, liver weight gain, white adipose tissue, lipid accumulation, and blood glucose. The levels of TG, ALT, AST, and inflammatory‐related adipokines (TNF‐α and IL‐6) in serum were also reduced by FMS. In addition, FMS promoted thermogenesis in brown adipose tissue and induced the activation of lipolysis, fatty acid oxidation, and oxidative phosphorylation in white adipose tissues. In summary, long‐term administration of FMS could ameliorate high‐fat diet–induced obesity by stimulating adipose thermogenesis and lipid metabolism.

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Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model

Cited by 15 publications

References 46 publications

The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

Diversifikasi Produksi Susu Kedelai Berbasis Mikroalga Autotrofik Guna Meningkatkan Indeks Nutraseutikal

Flavonoid‐enriched extract from Millettia speciosa Champ prevents obesity by regulating thermogenesis and lipid metabolism in high‐fat diet–induced obese C57BL/6 mice

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