Flavonoid‐enriched extract from Millettia speciosa Champ prevents obesity by regulating thermogenesis and lipid metabolism in high‐fat diet–induced obese C57BL/6 mice

Abstract

Millettia speciosa (M. speciosa) Champ is a medicinal and edible plant. The roots are rich in flavonoids, which possess multiple biological activities, including lipid‐lowering effects. This study aimed to explore the effect of flavonoid‐enriched extract from M. speciosa (FMS) on obesity. The UPLC‐Q‐TOF‐MS analysis and chromatographic analysis were adopted to identify flavonoid compounds in FMS. Male C57BL/6J mice were fed with a high‐fat diet for 3 months and were then treated with FMS (50 or 100 mg/kg/d) or Orlistat (10 mg kg−1 d−1) for another 8 weeks. A total of 35 flavonoids were identified in the extract of M. speciosa root. FMS reduced body weight gain, liver weight gain, white adipose tissue, lipid accumulation, and blood glucose. The levels of TG, ALT, AST, and inflammatory‐related adipokines (TNF‐α and IL‐6) in serum were also reduced by FMS. In addition, FMS promoted thermogenesis in brown adipose tissue and induced the activation of lipolysis, fatty acid oxidation, and oxidative phosphorylation in white adipose tissues. In summary, long‐term administration of FMS could ameliorate high‐fat diet–induced obesity by stimulating adipose thermogenesis and lipid metabolism.

Morphological, anatomical and genetic diversity of Nanhaia speciosa (Champ. ex Benth.) J.Compton & Schrire from Northern Vietnam

“…A crude extract of NP demonstrated antiobesity effects in a mouse model fed a high-fat diet. Another study also showed that flavonoids extracted from N. speciosa, similar to polysaccharides, help prevent obesity by regulating thermogenesis and lipid metabolism in mice (Wang et al 2022a). NP restored the balance of gut microbiota, becoming a promising prebiotic for managing obesity (Li et al 2022).…”

Anthocyanins from Lycium ruthenicum Murray attenuates high‐fat diet‐induced hypercholesterolemia in ApoE−/− mice are related to the modulation of gut microbiota and the ratio of conjugated to unconjugated bile acids in fecal bile acid profile

“…Numerous experimental and epidemiological research have proven that taking foods abundant in polyphenols and dietary supplements can effectively decrease the risk of developing CVD (Scalbert et al., 2005 ). Clinical trials and animal studies suggested that polyphenols could modify glucose and lipid metabolism (Matacchione et al., 2020 ; Ramos et al., 2023 ; Wang, Ma, et al., 2022 ). Berries are well‐described as interesting sources of polyphenols, especially anthocyanins (de Souza et al., 2014 ).…”

Quality control for a traditional Chinese medicine, Millettia speciosa Champ, using ultra-high-performance liquid chromatography fingerprint, serum pharmacochemistry and network pharmacology

“…Millettia speciosa ( M. speciosa ) Champ (MSC), alias Niudali—the dry root of Millettia genus of the Leguminosae family—is a healthy food type with medicinal and edible homology, which preferentially grows in tropical and subtropical areas, primarily including the Guangdong, Guangxi and Hainan provinces of China. 1,2 It tastes sweet, has little odour, and shows outstanding capacity for restoring lungs and loins, strengthening tendons, and improving kidney function. 3 According to recorded annals, its medicinal history dates back to the late Ming and early Qing dynasties, when its many virtues were recorded, including tonifying deficient Runfei, stimulating blood circulation, and relaxing muscles and joints.…”