Effects of a home‐based exercise program on metabolic risk factors and fitness in long‐term survivors of childhood acute lymphoblastic leukemia

Järvelä, Liisa S.; Kemppainen, Jukka; Niinikoski, Harri; Hannukainen, Jarna C.; Lähteenmäki, Päivi; Kapanen, Jukka; Arola, Mikko; Heinonen, Olli J.

doi:10.1002/pbc.24049

Cited by 74 publications

(121 citation statements)

References 44 publications

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“…Careful readings of the 22 full manuscripts further reduced the field to nine studies that met all inclusion criteria. [33][34][35][36][37][38][39][40][41][42] Of these studies, six included adolescent survivors, two addressed young adult survivors only, and one included both young adult and adolescent survivors. Interventions were heterogeneous across study design (nonrandomized, noncontrolled versus randomized, controlled trial), sample sizes (range =10-251), ages (range =3-39 years of age), diagnoses (acute lymphoblastic leukemia [ALL], brain tumor, mixed diagnoses), and points of intervention (on-treatment, immediate postcompletion of treatment, long-term survivorship).…”

Section: Exercise Strategies In Aya Cancer Survivors -A Review Of Thementioning

confidence: 99%

“…For example, Järvelä et al's homebased exercise intervention included self-monitoring and problem-solving skills training, as compared to Valle et al's intervention, which utilized psychoeducation, goal-setting, self-monitoring, and social support delivered via an Internetbased platform. 41,42 Given the variability in type, number, and delivery method of exercise-promoting strategies, definitive conclusions guiding recommendations for duration, intensity, and modality are limited at this time.…”

Section: Exercise Strategies In Aya Cancer Survivors -A Review Of Thementioning

confidence: 99%

“…34,42 In conjunction with self-monitoring that allows AYAs to identify patterns of exercise and barriers to engagement, problem-solving skills training to generate solutions to identified barriers is also a well-supported strategy to improve health behavior engagement in several chronic illness groups. 63 Problem-solving skills training generally consists of the following components: defining the problem, generating alternative solutions, deciding on a solution, and implementing and evaluating the solution.…”

Section: Problem-solving Skills Trainingmentioning

confidence: 99%

“…59,60 Self-monitoring Six of the nine interventions reported utilizing self-monitoring as a component in their intervention. 33,35,36,[40][41][42] Selfmonitoring of a desired behavior is a core component of self-regulation as it precedes and supports one's ability to evaluate whether progress has been made toward an intended goal. 61,62 It requires deliberate attention to a behavior and the details of that behavior with documentation of these details over time.…”

Section: Goal-settingmentioning

confidence: 99%

“…42 The home exercise program consisted of 3-4 days per week of strength exercises, and aerobic exercise of the survivor's choice for 30 minutes or more three times per week was encouraged. Self-monitoring was encouraged to monitor daily engagement in exercise.…”

Section: Exercise Strategies In Aya Cancer Survivors -A Review Of Thementioning

confidence: 99%

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Strategies to promote regular exercise in adolescent and young adult cancer survivors

Barnes

Casazza²,

Austin³

2015

COAYA

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Adolescents and young adults (AYAs) diagnosed with cancer are at increased risk for current and future health problems and premature death. Given the known risks for increased mortality and morbidity, fostering the development of exercise behaviors that may target the specific late effects experienced by AYA cancer survivors is crucial for healthy aging. Exercise is particularly important in the mitigation of late effects as it alters metabolic pathways that ultimately influence the development of chronic diseases associated with cancer treatment in AYAs. Despite the importance of exercise, a large proportion of AYA survivors do not meet recommended guidelines for exercise. The current review summarizes the beneficial effects of exercise in AYA survivors, evaluates strategies utilized in interventions that have been developed to address exercise engagement, and provides recommendations for psychosocial strategies on how to improve these behaviors in this population. A total of nine empirical articles examining exercise interventions in AYAs with a history of cancer were included for review. While several exercise strategies appear promising, more research is needed to evaluate long-term influence of strategies on exercise engagement, as well as the interactions these strategies have on AYA exercise maintenance and health outcomes as they continue into adulthood. Future interventions should evaluate key psychosocial strategies to increase both short-and long-term exercise adherence as well as overall health benefits.

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Section: Exercise Strategies In Aya Cancer Survivors -A Review Of Thementioning

confidence: 99%

Section: Exercise Strategies In Aya Cancer Survivors -A Review Of Thementioning

confidence: 99%

Section: Problem-solving Skills Trainingmentioning

confidence: 99%

Section: Goal-settingmentioning

confidence: 99%

Section: Exercise Strategies In Aya Cancer Survivors -A Review Of Thementioning

confidence: 99%

See 3 more Smart Citations

Strategies to promote regular exercise in adolescent and young adult cancer survivors

Barnes

Casazza²,

Austin³

2015

COAYA

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Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Phillips

Howell

Lanctot

et al. 2019

Cancer

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BACKGROUND: Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment-related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between exercise intolerance and neurocognitive impairments in ALL survivors. METHODS: Cardiopulmonary exercise testing, results from a 2-hour standardized neuropsychological assessment, and self-report questionnaires were obtained for 341 adult survivors of childhood ALL and 288 controls. Multivariable modeling was used to test associations between oxygen uptake at 85% estimated heart rate (rpkVO 2 ) and neuropsychological test and self-reported questionnaire domains, adjusted for sex, age at diagnosis, cranial radiation, anthracycline, and methotrexate exposure and tobacco smoking status. RESULTS: Compared with controls, survivors had worse rpkVO 2 and performance on verbal intelligence, focused attention, verbal fluency, working memory, dominant/nondominant motor speed, visual-motor speed, memory span, and reading and math measures (all P < .001). In adjusted models, exercise intolerance was associated with decreases in performance of verbal ability, focused attention, verbal fluency, working memory, dominant motor speed, nondominant motor speed, visual-motor speed, memory span, reading academics, and math academics in survivors. CONCLUSION: This study demonstrates an association between exercise intolerance and neurocognitive outcomes. Research is needed to determine whether interventions that improve exercise tolerance impact neurocognitive function in ALL survivors. Cancer 2020;126:640-648.

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Exercise Training in Cancer Control and Treatment

Christensen

Simonsen

Højman

2018

Comprehensive Physiology

166

127

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Exercise training is playing an increasing role in cancer care, as accumulating evidence demonstrates that exercise may prevent cancer, control disease progression, interact with anti‐cancer therapies, and improve physical functioning and psychosocial outcomes. In this overview article, we present the current state of the field of exercise oncology, which currently comprises of nearly 700 unique exercise intervention trials with more than 50,000 cancer patients. First, we summarize the range of these interventions with regard to diagnoses, clinical setting, timing, and type of intervention. Next, we provide a detailed discussion of the 292 trials, which have delivered structured exercise programs, outlining the impact of exercise training on cancer‐specific, physiological, and psychosocial outcomes in the light of the challenges and physiological limitations cancer patients may experience. In summary, the safety and feasibility of exercise training is firmly established across the cancer continuum, and a wide range of beneficial effects on psychosocial and physiological outcomes are well documented. Many of these beneficial effects are linked to the general health‐promoting properties of exercise. However, it is becoming increasing evident that exercise training can have direct effects on cancer and its treatment. This calls for future exercise oncology initiatives, which aim to target cancer‐specific outcomes, and which are integrated into the concurrent cancer trajectory. Here, the field must bridge extensive knowledge of integrative exercise physiology with clinical oncology and cancer biology to provide a basis of individualized targeted approaches, which may place exercise training as an integrated component of standard cancer care. © 2019 American Physiological Society. Compr Physiol 9:165‐205, 2019.

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Effects of a home‐based exercise program on metabolic risk factors and fitness in long‐term survivors of childhood acute lymphoblastic leukemia

Cited by 74 publications

References 44 publications

Strategies to promote regular exercise in adolescent and young adult cancer survivors

Strategies to promote regular exercise in adolescent and young adult cancer survivors

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Exercise Training in Cancer Control and Treatment

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