Effects of a lesion in the dorsal raphe nuclei performed during the juvenile period of the female rat, on puberty

Ayala, Marı́a Elena; Monroy, Juana; Morales, Leticia; Castro, Marta E; Domı́nguez, Roberto

doi:10.1016/s0361-9230(98)00074-4

Cited by 19 publications

(10 citation statements)

References 18 publications

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“…While the role of 5HT2c receptor in puberty is unknown, serotonin is involved in the initiation of puberty in rodents delaying puberty when injected systemically [26;61]. However, lesions of the dorsal raphe (containing serotonergic neurons) at PND 21 delayed vaginal opening and first vaginal estrus (ovulation) in rats while lesions after weaning (PND 24/27) did not [62], indicating that serotonin controls puberty onset. In our study, two compounds advanced puberty, DES and MXC, the latter also suppressed 5HT2c receptor expression.…”

Section: Discussionmentioning

confidence: 99%

Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats

Roepke

Yang

Yasrebi

et al. 2016

Reproductive Toxicology

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Developmental exposure to endocrine-disrupting compounds (EDCs) alters reproduction and energy homeostasis, both of which are regulated by the arcuate nucleus (ARC). Little is known about the effects of EDC on ARC gene expression. In Experiment #1, pregnant dams were treated with either two doses of bisphenol A (BPA) or oil from embryonic day (E)18-21. Neonates were injected from postnatal day (PND)0-7. Vaginal opening, body weights, and ARC gene expression were measured. Chrm3 (muscarinic receptor 3) and Adipor1 (adiponectin receptor 1) were decreased by BPA. Bdnf (brain-derived neurotropic factor), Igf1 (insulin-like growth factor 1), Htr2c (5-hydroxytryptamine receptor), and Cck2r (cholescystokinin 2 receptor) were impacted. In Experiment #2, females were exposed to BPA, diethylstilbestrol (DES), di(2-ethylhexyl)phthalate, or methoxychlor (MXC) during E11-PND7. MXC and DES advanced the age of vaginal opening and ARC gene expression was impacted. These data indicate that EDCs alter ARC genes involved in reproduction and energy homeostasis in females.

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Section: Discussionmentioning

confidence: 99%

Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats

Roepke

Yang

Yasrebi

et al. 2016

Reproductive Toxicology

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“…Kohn and Barthold (1984) report 40-60 days, and Bennett and Vickery (1970) report 50-72 days. More recently, Ayala et al (1998) report 45-47 days. Estrus, which should be distinguished from puberty, begins before full reproductive competency is reached and has been reported to occur at 36 days in the Wistar rat (Eckstein et al, 1973).…”

Section: Reproductive Physiologymentioning

confidence: 99%

Biology and Diseases of Rats

Kohn¹,

Clifford²

2002

Laboratory Animal Medicine

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“…A study in Wistar rats documented vaginal opening in control females at approximately 36 days of age and balano-preputial separation in control males at approximately 46 days of age (Engelbregt et al, 2000). Kohn and Barthold (1984) report 40-60 days, Bennett and Vickery (1970) report 50-72 days, and Ayala et al (1998) report 45-47 days. As in most species, puberty occurs in females earlier than in males and also varies with stock or strain.…”

Section: Reproductive Physiologymentioning

confidence: 99%