Effects of a leucine-rich diet on body composition during nutritional recovery in rats

Ventrucci, Gislaine; Silva, Luis Gustavo Ramos; Mello, Maria Alice Roston de; Marcondes, Maria Cristina Cintra Gomes

doi:10.1016/j.nut.2003.10.014

Cited by 40 publications

(36 citation statements)

References 29 publications

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“…Thus, it is believed that the normal protein diet (17 % protein) offered to the offspring in the period following and into adulthood was insufficient to promote the recovery of muscle weight. Rats malnourished during pregnancy and lactation presented reduced weight in the anterior tibialis muscle (Ventrucci et al, 2004;Alves et al, 2008). Although a different muscle, this is a fast twitch muscle similar to that used in this study.…”

Section: Discussionmentioning

confidence: 71%

Morphological and Morphometric Study of the Muscle Fibers and Neuromuscular Junctions of the Extensor Digitorum Longus in Aged Rats Submitted to Maternal Protein Restriction

et al. 2016

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SUMMARY:Protein restriction implies the functional involvement of several systems and organs, including the skeletal muscle, because it is a protein reservoir in the body. This study sought to analyze the morphological and morphometric features of the muscle fibers and neuromuscular junctions (NMJs) of the extensor digitorum longus (EDL) muscle in rats at 365 days of age, submitted to maternal protein restriction during the gestation and lactation periods. Wistar rats were divided into two groups: a Control Groupmothers fed a normal-protein diet (17 % protein) during pregnancy and lactation; and a Restricted Group -mothers fed a low-protein diet (6 % protein) during pregnancy and lactation. The pups were kept with the mother throughout the lactation period (21 days), after which the offspring received a normal protein diet until 365 days of age. Histological (HE) and histoenzymological (NADH-TR) studies were conducted on the muscle fibers. The muscle was subjected to Nonspecific Esterase reaction to stain the Neuromuscular Junctions. Regarding the animals from the restricted group: the histologic analysis of the muscle fibers showed the presence of centralized nuclei and a diminished area; the histoenzymological study showed the different types of muscle fibers were randomly distributed in the EDL muscle and the area of the Type IIa muscle fiber was smaller; the ultrastructural study revealed disorganization of the Z line, and the presence of lipid droplets and vacuoles containing myelin figures in subsarcolemmal and intramiofibrilar regions; while the analysis of the NMJs exhibited no significant differences between the groups. Protein restriction in the pregnancy and lactation period may have affected the development of skeletal muscle, producing a permanent muscle-fiber deficit in the EDL muscle of the offspring.

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Section: Discussionmentioning

confidence: 71%

Morphological and Morphometric Study of the Muscle Fibers and Neuromuscular Junctions of the Extensor Digitorum Longus in Aged Rats Submitted to Maternal Protein Restriction

et al. 2016

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“…This supposition is reinforced by the observation that malnutrition has dramatic effects on small intestinal mucosal structure and transport activity, reducing the specific aminoacid absorption that remains impaired even after nutritional recovery (33). Curiously, the recovered groups that had lower protein digestibility demonstrated higher protein efficiency and equal energy efficiency.…”

Section: Nutritional Recovery With Rice Branmentioning

confidence: 99%

Nutritional recovery with rice bran did not modify energy balance and leptin and insulin levels

Martins

Oyama

Latorraca

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the effect of nutritional recovery with rice bran on energy balance, leptin and insulin levels. Methods: Weaned Wistar rats were fed on a 17% (Control − C) or 0.5% (Aproteic − A) protein diet for 12d. After this, rats were kept on a C diet (C) or recovered with control (Recovered Control − RC) or control plus recovered rice bran diet (Recovered Rice Bran − RRB). Results: Despite the increased food intake, group A exhibited lower carcass fat associated to low serum leptin. RRB and RC groups showed lower carcass weight and energy intake and expenditure. Energy expenditure was positively associated with food intake and carcass weight. Negative correlations between HOMA-IR and energy expenditure and energy intake were observed. Conclusion: Nutritional recovery with rice bran did not modify energy balance, leptin and insulin levels. Arq Bras Endocrinol Metab. 2010;54(3):289-94 Keywords Energy balance; leptin; insulin; rice bran; nutritional recovery RESUMO Objetivo: Investigar o efeito da recuperação nutricional com farelo de arroz sobre o balanço energético e níveis de leptina e insulina. Métodos: Ratos Wistar recém-desmamados foram alimentados com 17% (Controle − C) ou 0,5% (Aproteico − A) de proteína (caseína) durante 12 dias. Em seguida, ratos permaneceram com dieta controle (C) ou foram recuperados com controle (Recuperados Controle − RC) ou controle mais 5% de farelo de arroz (Recuperados com Farelo de Arroz − RFA) durante 21 dias. Resultados: Apesar de a ingestão alimentar ter sido maior em A, a gordura na carcaça foi reduzida, sendo associada com menor nível de leptina. Os grupos RFA e RC tiveram redução no peso da carcaça, no gasto e ingestão de energia. O gasto energético foi correlacionado com a ingestão de alimentos e o peso da carcaça fresco. Foi observada correlação negativa entre HOMA-IR com gasto energético e com ingestão de energia. Conclusão: A recuperação nutricional com farelo de arroz não modificou o balanço energético, nem os níveis de leptina e insulina. Arq Bras Endocrinol Metab. 2010;54(3):289-94

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“…The predominant effect of leucine on the metabolic regulation of the muscle protein synthesis indicates that leucine stimulates the synthesis and inhibits protein degradability (NAIR; SCHWARTZ; WELLE, 1992, DARDEVET et al, 2002, VENTRUCCI et al, 2004, COMBARET et al, 2005RIEU et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Elaboration of biscuits with oatmeal and fat palm with added L-leucine and calcium for sarcopenia

et al. 2013

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Effects of a leucine-rich diet on body composition during nutritional recovery in rats

Cited by 40 publications

References 29 publications

Morphological and Morphometric Study of the Muscle Fibers and Neuromuscular Junctions of the Extensor Digitorum Longus in Aged Rats Submitted to Maternal Protein Restriction

Morphological and Morphometric Study of the Muscle Fibers and Neuromuscular Junctions of the Extensor Digitorum Longus in Aged Rats Submitted to Maternal Protein Restriction

Nutritional recovery with rice bran did not modify energy balance and leptin and insulin levels

Elaboration of biscuits with oatmeal and fat palm with added L-leucine and calcium for sarcopenia

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