Effects of a long-distance run on cardiac markers in healthy athletes

Leers, Mathie P.G.; Schepers, Raymond; Baumgarten, Ruben

doi:10.1515/cclm.2006.179

Cited by 56 publications

(49 citation statements)

References 19 publications

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“…The kinetic profile of cTnI and cTnT circulating levels after strenuous exercise in apparently healthy subjects [25,40,[52][53][54][55][56][77][78][79][80][81][82][83][84][85][86][87][88][89][90] is different from that usually observed in patients with AMI. It is well known that circulating levels of cTnI and cTnT in patients with uncomplicated type 1 AMI usually peak between 12 and 36 h from beginning of thoracic pain, gradually returning to below the 99th URL value within 5-7 days [1,3,40,76].…”

Section: Mechanisms Of Troponin Release In Cardiac Patients and Healtmentioning

confidence: 99%

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Clerico

Zaninotto

Ripoli

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit (99th URL) should be considered clinically relevant, this cut-off being measured with an imprecision ≤10 CV%. In theory 99th URL values strongly depend not only on demographic and physiological variables (i.e. criteria for considering the reference population "healthy"), but also on the analytical performance of cTn methods and mathematical algorithms used for the calculation. The aim of the present article was therefore to review the methodological and pathophysiological factors affecting the evaluation and calculation of the 99th URL for cTn assay. The critical analysis made showed that no uniform procedure is followed, and nor have experts or regulatory bodies provided uniform guidelines for researchers or cTn assays manufacturers as an aid in "their quest to define normality". In particular, little attention has been paid to the way in which a healthy reference population is to be selected, or the criteria for calculating the 99th URL value for cTn assays, thus highlighting the need for international recommendations not only for demographic and physiological variables criteria for defining a healthy reference population, but also for calculating mathematical algorithms for establishing/ calculating clinical decision values. An expert consensus group, comprising laboratory and clinical scientists, biomedical statisticians, industrial and regulatory representatives, should be responsible for drawing up these guidelines.

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Section: Mechanisms Of Troponin Release In Cardiac Patients and Healtmentioning

confidence: 99%

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Clerico

Zaninotto

Ripoli

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…The effect of prolonged strenuous exercise on systemic cardiac markers of damage has been studied extensively, [18][19][20] with evidence of transient elevations during and immediately after exercise, which return to normal within 3 days in healthy athletes. 18,19 These temporary elevations have been hypothesised to be due to myocardial stress and reversible cardiomyocyte membrane damage.…”

Section: Systemic Markers Of Cardiac Damagementioning

confidence: 99%

Section: Systemic Markers Of Cardiac Damagementioning

confidence: 99%

“…18,19 These temporary elevations have been hypothesised to be due to myocardial stress and reversible cardiomyocyte membrane damage. 18,19 Exercise is known to cause an increased myocardial oxygen demand and cardiac troponin turnover in all athletes, 18 which might be linked to tachyarrhythmias and sudden cardiac death, when associated with prolonged increases (>3 days) in cTnT concentrations above 0.05µg/l. 18 At no stage during our study were increased cTnT concentrations measured, supporting the attenuated increase in serum CPK concentration and absent uMb values as well as the lower concentration of serum cortisol despite maintenance of an intensity of effort which fluctuated from 63 to 112% APmax.…”

Section: Systemic Markers Of Cardiac Damagementioning

confidence: 99%

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Low markers of muscle damage and inflammation following a 3-day trail run

Denissen

Waard

Singh

et al. 2012

S. Afr. j. sports med.

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Objectives. To investigate the effect of a 3-day trail run on markersof muscle damage and inflammation in recreational runners.Main outcome measures. Pre-and post-stage and 24-hour and 72-hour post-race concentrations of serum creatine phosphokinase (CPK), high sensitivity C-reactive Protein (hsCRP), cortisol, cardiac Troponin T (cTnT), and osmolality (sOsm) as well as urinary myoglobin (uMb), changes in body mass, delayed onset muscle soreness (DOMS) and thigh circumference (TC) were measured. Continuous recordings of heart rate (HR) and intestinal temperature (Tintest ) were made throughout each stage.Results. Heart rate ranged between 77% and 83% age-predicted maximum (APmax) and Tintest between 36.1 and 40.2ºC during the three stages. Significant rises in mean serum CPK, hsCRP, sOsm and blood neutrophil count reached peak concentrations of 1488U/l, 8.91mg/l, 298mosm/l and 10.21 109/l (p<0.001), respectively. No evidence of elevations in uMb and cTnT were detected. The stage-induced increments in DOMS correlated positively with CPK, r=0.71; 95% CI [0.62, 0.78], TC decreased significantly post S1post and S2post (p<0.05) and a maximum mean body mass loss of 3.09% (±1.04%) occurred during S2.Conclusion. Three consecutive days of 95-km trail running resulted in low markers of muscle damage and inflammation, despite the maintenance of a heart rate above 77% APmax, Tintest rising above 39oC and mean body mass decrement of >2.0%.

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“…This suggests that central NTproBNP (ng/mL) may also take part in the neuro-modulatory system that controls emotional behavior and the stress hormone cascade [16]. While there are data in the medical literature on NTproBNP (ng/mL) responses to acute physical stress [17][18][19][20][21][22][23], few data are available on systemic NTproBNP (ng/mL) responses to acute psychological and physiological stress. Moreover, it has been proposed that the cardiac endocrine response may be regulated differently by several types of stressors [24][25].…”

Section: Introductionmentioning

confidence: 99%

The effect of the Wingate Anaerobic Test on NTproBNP, lactate and blood pressure in wrestlers and untrained young healthy males

Saghiv¹,

Cummings²,

Kusser³

et al. 2017

J Integr Cardiol

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Purpose: To investigate the influence of the WAnT on blood pressure, lactate, and NTproBNP in trained Wrestlers and untrained young males.Methods: 20 males (n=20), ages 18-25 underwent the WAnT. The study included 2 groups. Group 1 included 10 untrained individuals, and group 2 included 10 wrestlers. NTproBNP (ng/mL), lactate (mmol/ L), and blood pressure (mmHg) were measured at rest, immediate-post, two minutes post, and ten minutes post. The mechanical outputs (W) calculated for each subject. NTproBNP was analyzed utilizing ELIZA.Results: The wrestler's resting NTproBNP levels were higher (35.5 ± 7.59 vs. 35.15 ± 4.82 accordingly), with non-significant differences between the groups. Immediate Post NTproBNP was higher for wrestlers (40.25 ± 14.08 vs. 37.33 ± 9.94) with a positive and strong correlation between PP and IP NTproBNP (r = 0.85). While the untrained had a substantially higher post 10 NTproBNP (45.07 ± 11.75 vs. 32 ± 5.57), both group's NTproBNP was elevated post 10 minutes with a significant difference from post 2 minutes values (p=0.035). PP was significantly higher for the wrestlers (1031.6 ± 188.65 vs. 960.91 ± 189.01). No significant differences were found between groups for RPP and RMP. Conclusions:NTproBNP values were within the ranges reported in the literature. The WAnT did not put any of the subjects at risk due to cardiac stress. The recovery dynamics regarding NTproBNP were different between groups. Wrestlers recovered rapidly with a slight elevation 10 minutes post-test, while the untrained recovered slowly with a significant elevation of NTproBNP 10 minutes post-test.

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Effects of a long-distance run on cardiac markers in healthy athletes

Cited by 56 publications

References 19 publications

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Low markers of muscle damage and inflammation following a 3-day trail run

The effect of the Wingate Anaerobic Test on NTproBNP, lactate and blood pressure in wrestlers and untrained young healthy males

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