Effects of a Novel Hydration Accelerant on the Biological and Mechanical Properties of White Mineral Trioxide Aggregate

Composition and Setting Reaction

“…These include local anaesthetic solution [40,50,53,81,83], sodium hypochlorite, chlorhexidine gluconate, saline and physiological solution [42,50,53], calcium lactate gluconate [51,56] and citric acid [56]. The use of unhydrated MTA as a root-end filling material has been reported [67].…”

Material Modifications and Related Materials

“…A reduced setting time, inferior compressive strength, and lower pH in MTA mixed with CLG [ 109 ] were reported, although its sealing ability was improved [ 92 ] and adequate biocompatibility [ 98 ] was observed. The biocompatibility of MTA mixed with different hydration accelerators such as calcium chloride, calcium lactate gluconate, and citric acid was assessed [ 99 ].…”

Cytotoxic effects of new MTA-based cement formulations on fibroblast-like MDPL-20 cells

“…7,8,9 The ability of tissue to regenerate and the antibacterial property of MTA-based cements are related to ionic dissociation in calcium and hydroxyl ions. 10 The calcium ions released by the cement react and produce calcite granules, when the cement comes into contact with the carbon dioxide and carbonic acid from the cell catabolism. 7 In addition, there is a tendency for fibronectin to accumulate.…”

“…12 A long exposure period of cells to the cement before its complete hardening may compromise its biological property, leading to an inflammatory reaction, which may affect its physical characteristics. 10 A novel experimental cement, called CER, was developed to improve some undesirable characteristics of MTA cement, such as poor handling from porosities formed after manipulation, 1 making it highly unstable, high solubility, 9 long setting time, 10 and dental staining. 3,12 The name CER is the Portuguese acronym for "cimento endodôntico rápido", or "quick-setting endodontic cement" in English.…”