Effects of a nutritional supplement on the immune response and cytokine production in free‐living Chilean elderly

Bunout, Daniel; Barrera, Gabriela; Hirsch, S; Gattás, Vivien; Maza, MP de la; Haschke, F.; Steenhout, Philippe; Klassen, Preston S.; Häger, Christine; Avendaño, María José; Petermann, Marcus; Muñoz, Carlos

doi:10.1177/0148607104028005348

Cited by 120 publications

(86 citation statements)

References 28 publications

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“…No effect on antibody response to vaccines Significantly lower incidence of infection after 12 months, in particular respiratory illnesses, in treatment group v. controls (P = 0·034) (76) H1N1 following intervention with Lactobacillus fermentum VRI 003 for 6 weeks in total (vaccination after 2 weeks), but there were no differences for other subunits. The average number of days of respiratory symptoms was reduced from 5 to 2 d (73) .…”

Section: Probiotics and The Immune Response To Influenza Vaccinationmentioning

confidence: 95%

“…Four out of eight of the studies investigating the impact of probiotics on responses to influenza vaccination were conducted in healthy adults (72)(73)(74)(75) , while the remaining four were conducted in elderly subjects (76)(77)(78)(79) ; three of these were conducted in institutionalised individuals (77)(78)(79) (Table 1). The largest of the trials conducted in elderly subjects (n 362 and 375 on probiotic and placebo, respectively) demonstrated no effect of L. casei Shirota on respiratory infections, seroprotection, seroconversion or mean antibody titres (79) .…”

Section: Probiotics and The Immune Response To Influenza Vaccinationmentioning

confidence: 99%

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Ageing, immunity and influenza: a role for probiotics?

Yaqoob

2013

Proc. Nutr. Soc.

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Influenza is a major cause of death in the over 65s. Increased susceptibility to infection and reduced response to vaccination are due to immunosenscence in combination with medical history and lifestyle factors. Age-related alterations in the composition of the gut microbiota have a direct impact on the immune system and it is proposed that modulation of the gut microbiota using pre- and probiotics could offer an opportunity to improve immune responses to infections and vaccination in older people. There is growing evidence that probiotics have immunomodulatory properties, which to some extent are strain-dependent, and are strongly influenced by ageing. Randomised controlled trials suggest that probiotics may reduce the incidence and/or severity of respiratory infections, although there is limited data on older people. A small number of studies have examined the potential adjuvant effects of selected probiotics for vaccination against influenza; however, the data is inconsistent, particularly in older people. This review describes the impact of age-related changes in the gut on the immune response to respiratory infections and evaluates whether restoration of gut microbial homoeostasis by probiotics offers an opportunity to modulate the outcome of respiratory infections and vaccination against influenza in older people. Although there is promising evidence for effects of probiotics on human health, there is a lack of consistent data, perhaps partly due to strain-specific differences and an influence of the age of the host. Further research is critical in evaluating the potential use of probiotics in respiratory infections and vaccination in the ageing population.

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Section: Probiotics and The Immune Response To Influenza Vaccinationmentioning

confidence: 95%

Section: Probiotics and The Immune Response To Influenza Vaccinationmentioning

confidence: 99%

Ageing, immunity and influenza: a role for probiotics?

Yaqoob

2013

Proc. Nutr. Soc.

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“…Also amino acids, the modules of proteins, contribute to the maintenance of an intact immune system by ensuring the generation of the scavenger glutathione, for example. A high impact on beneficial intestinal bacteria, which boost immune properties, could be demonstrated by synbiotica (probiotica and prebiotica) [77].…”

Section: Elderly Peoplementioning

confidence: 99%

Overview of the physiological changes and optimal diet in the golden age generation over 50

Gille

2010

Eur Rev Aging Phys Act

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Basically, our lifespan is determined genetically. However, several other parameters such as the environment, lifestyle and diet have a high impact on living in the best of health. Many older persons suffer from various diseases, which often cannot be avoided; however, their development can be postponed and symptoms can be mitigated by a balanced diet, moderate physical activity as well as a healthy lifestyle. These diseases are, for example, sarcopenia (degenerative loss of muscle mass), osteoporosis (decomposition of bone structure), digestive restrictions, sensory impairment, water imbalance or a compromised immune system. Psychological modifications, obesity and loss of weight also commonly occur in older adults. To define an adequate diet for elderly between the ages 50 and 80 is difficult, even impossible, because the nutritional requirements differ between the dynamic quinquagenarian and the frailer eighty-year-old. However, several studies have shown that sufficient consumption of high-quality proteins, calcium, vitamin D, anti-oxidative food compounds, water as well as adapted energy values and nourishment with high-nutrient density in combination with physical activity especially help one to remain healthy to a great age. The cornerstone of healthy ageing is the maintenance of normal bodyweight in order to prevent the development of diseases such as osteoporosis, coronary heart disease or diabetes type 2. This publication will review the physiological changes that occur with advanced age and consequential nutritional recommendations for elderly persons.

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“…It has been proposed that enhancement of probiotic bacteria in the intestines provides advantages to the host [19]. It was also demonstrated that synbiotic nutritional supplements consisting of probiotic L. paracasei and prebiotic fructooligosaccharides efficiently increased NK cell activity in elderly people [20]. Recently, we have shown that L. casei ssp.…”

Section: Introductionmentioning

confidence: 99%

Natural killer cell activities of synbiotic Lactobacillus casei ssp. casei in conjunction with dextran

Ogawa

Asai

Tamai

et al. 2005

Clinical and Experimental Immunology

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Effects of a nutritional supplement on the immune response and cytokine production in free‐living Chilean elderly

Abstract: This nutritional supplement increased innate immunity and protection against infections in elderly people.

Cited by 120 publications

References 28 publications

Ageing, immunity and influenza: a role for probiotics?

Ageing, immunity and influenza: a role for probiotics?

Overview of the physiological changes and optimal diet in the golden age generation over 50

Natural killer cell activities of synbiotic Lactobacillus casei ssp. casei in conjunction with dextran

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