Effects of a probiotic <i>Enterococcus faecium</i> strain supplemented from birth to weaning on diarrhoea patterns and performance of piglets*

Zeyner, Annette; Boldt, E.

doi:10.1111/j.1439-0396.2005.00615.x

Cited by 93 publications

(68 citation statements)

References 30 publications

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“…Other studies reported a reduction in the level of pathogenic intestinal bacteria after application of Enterococcus spp. to test animals (24,26,34) and a reduction in diarrhea in piglets (36,44). However, negative effects on the intestinal flora have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Influence of a Probiotic Strain ofEnterococcus faeciumonSalmonella entericaSerovar Typhimurium DT104 Infection in a Porcine Animal Infection Model

Szabó

Wieler

Tedin

et al. 2009

Appl Environ Microbiol

103

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The beneficial effects of probiotic Enterococcus spp. in different hosts, such as mice and humans, have previously been reported in several studies. However, studies of large domestic animals, as well as challenge studies with pathogenic microorganisms, are very rare. Here, we investigated the influence of oral treatment of pigs with the probiotic bacterium Enterococcus faecium NCIMB 10415 on Salmonella enterica serovar Typhimurium DT104 infections in weaning piglets. Clinical symptoms, fecal excretion, the organ distribution of Salmonella, and the humoral immune response (immunoglobulin G [IgG], IgM, and IgA levels) in serum were examined. A pool of 89 piglets was randomly divided into probiotic and control groups. The probiotic group received a feed supplement containing E. faecium starting on day 14 postpartum prior to challenge with Salmonella serovar Typhimurium DT104 at 28 days postpartum. After challenge with Salmonella serovar Typhimurium DT104, piglets in both groups showed no severe clinical signs of salmonellosis. However, fecal excretion and colonization of Salmonella in organs were significantly greater in piglets fed E. faecium. Likewise, the humoral immune response against Salmonella (serum IgM and IgA levels) was significantly greater in the probiotic group animals than in control animals. The results of this study suggest that E. faecium NCIMB 10415 treatment enhanced the course of infection in weaning piglets challenged with Salmonella serovar Typhimurium DT104. However, the probiotic treatment also appeared to result in greater production of specific antibodies against Salmonella serovar Typhimurium DT104.

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Section: Discussionmentioning

confidence: 99%

Influence of a Probiotic Strain ofEnterococcus faeciumonSalmonella entericaSerovar Typhimurium DT104 Infection in a Porcine Animal Infection Model

Szabó

Wieler

Tedin

et al. 2009

Appl Environ Microbiol

103

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“…For example, some studies using E. faecium NCIMB 10415 showed that diarrhea was reduced and performance increased (Taras et al 2006;Zeyner and Boldt, 2006;Büsing and Zeyner, 2015) whereas others did not (Broom et al 2006;Martin et al 2012). It was initially shown that E.…”

Section: Prevention Of Diarrheamentioning

confidence: 99%

“…Enterococcus faecium NCIMB 10415, a probiotic that can reduce diarrhea incidence in piglets (Büsing and Zeyner, 2015;Zeyner and Boldt, 2006), has been investigated in ETEC-infected IPEC-J2 cells, to deepen insight on the mechanisms underlying the bacterial-epithelial crosstalk during innate immune responses triggered by enteric infections. ETEC decreased transepithelial resistance (TEER) and increased IL-8 expression, and this effect could be prevented by both pre-incubation and simultaneous addition with E. faecium for up to 4 h Lodemann et al 2015).…”

Section: Probiotics Used In Pig Intestinal Cells Challenged With Etecmentioning

confidence: 99%

Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs

Roselli

Pieper

Rogel–Gaillard

et al. 2017

Animal Feed Science and Technology

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms HIGHLIGHTS-Updated literature overview about probiotics, prebiotics and synbiotics on pig gut health is provided -Both in vivo studies performed in pigs and in vitro studies conducted in pig intestinal cell lines are described -A critical outcome of the described results is provided -The concept of "proxy measurements" for pig gut health is widely discussed -The link between gut microbiota and mucsal immune system is described Abstract:Probiotics are live microorganisms that can confer a health benefit on the host, and amongst various mechanisms probiotics are believed to exert their effects by production of antimicrobial substances, competition with pathogens for adhesion sites and nutrients, enhancement of mucosal barrier integrity and immune modulation. Through these activities probiotics can support three core benefits for the host: supporting a healthy gut microbiota, a healthy digestive tract and a healthy immune system. More recently, the concept of combining probiotics and prebiotics, i.e. synbiotics, for the beneficial effect on gut health of pigs has attracted major interest, and examples of probiotic and prebiotic benefits for pigs are pathogen inhibition and immunomodulation. Yet, it remains to be defined in pigs, what exactly is a healthy gut. Because of the high level of variability in growth and feed conversion between individual pigs in commercial production systems, measuring the impact of probiotics on gut health defined by improvements in overall productivity requires large experiments. For this reason, many studies have concentrated on measuring the effects of the feed additives on proxies of gut health including many immunological measures, in more controlled experiments. With the major focus of studying the balance between gut microbiology, immunology and physiology, and the potential for prevention of intestinal disorders in pigs, we therefore performed a literature review of the immunomodulatory effects of probiotics, either alone or in combination with prebiotics, based on in vivo, in vitro and ex vivo porcine experiments. A 3 consistent number of studies showed the potential capacity in terms of immunomodulatory activities of these feed additives in pigs, but contrasting results can also be obtained from the literature.Reasons for this are not clear but could be related to differences with respect to the probiotic strain used, experimental settings, diets, initial microbiota colonization, administration route, time and frequency of administration of the probiotic strain and sampling for analysis. Hence, the use of proxy measurements of enteric health based on observable immunological parameters presents significant problems at the moment, and cannot be considered robust, reliable predictors of the probiotic activity in vivo, in relation to pig gut health. In c...

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“…In addition, numerous institution-based experiments (as opposed to real farm conditions) have shown that in-feed antimicrobials are at their most effective in animals being raised under sub-optimal conditions (Dritz et al, 2002). Where high welfare, high health status animals are used, as in agricultural research centres, the gains produced by in-feed antimicrobials are marginal, at best (Zeyner and Boldt, 2006). These findings may inform subsequent research into the efficacy of probiotics.…”

Section: Do Probiotics Work? -An Overviewmentioning

confidence: 99%

Probiotics – do they have a role in the pig industry?

Kenny

Smidt

Mengheri

et al. 2011

Animal

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The delivery of certain living microorganisms in food has long been suggested as having positive health effects in humans. This practice has extended into food animal production, with a variety of microorganisms being used; lactic acid bacteria, variousBacillusspecies and the yeastSaccharomyces cerevisiaehave been particularly used in the pig industry. The increased interest in probiotics is essentially due to the problem of microbial resistance to antibiotics and following the ban of the use of antibiotics in animal production, probiotics being considered an alternative means to reduce pathogen infection and improve animal health especially around the time of weaning. However, there is still a need to clarify the probiotic effectiveness in pigs, and the underlying mechanisms. When assessing the efficacy of probiotics one must consider the particular strain of organism being used and the production stage of the pigs being treated. The reproducible delivery of probiotics in industrial pig production is problematic as maintenance of viability is key to their beneficial activity, but difficult to achieve with commonly used feed processing technologies. One specific context where probiotics organisms may be reliably delivered is in systems utilising fermented liquid feeds. Liquid feed may be fermented by the activity of wild lactic acid bacteria or may be stimulated using specific isolates as ‘starters’; the latter system has advantages in terms of reproducibility and speed of fermentation. The farm context in which the organism is used is likely to be critical; the use of probiotics is more likely to result in measurable economic gains in animals living in sub-optimal conditions rather than in those reared in the highest welfare and husbandry conditions. The establishment of a beneficial lactic acid bacteria population at birth may lead to healthier animals, this may be most effectively achieved by treating sows, which provide an amplification step and flood the neonatal pigs’ environment with desirable bacterial strains. In contrast, it may be sufficient to provide a supportive, protective microbiota around the time of weaning as this is a time of major crisis with instability and loss of certain bacterial populations.

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Effects of a probiotic Enterococcus faecium strain supplemented from birth to weaning on diarrhoea patterns and performance of piglets*

Cited by 93 publications

References 30 publications

Influence of a Probiotic Strain ofEnterococcus faeciumonSalmonella entericaSerovar Typhimurium DT104 Infection in a Porcine Animal Infection Model

Influence of a Probiotic Strain ofEnterococcus faeciumonSalmonella entericaSerovar Typhimurium DT104 Infection in a Porcine Animal Infection Model

Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs

Probiotics – do they have a role in the pig industry?

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