Effects of a reputed immunostimulant on the innate immune system of goat kids

Morales-delaNuez, A.; Castro, N.; Moreno-Indias, Isabel; Juste, M.C.; Sánchez-Macías, D.; Briggs, H.; Capote, J.; Argüello, A.

doi:10.1016/j.smallrumres.2009.06.016

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…As it has been described by several authors, goat kids need to be fed an amount of colostrum equivalent to 4 g of IgG/kg of BW, divided into three meals before 48 h after birth, in order to make an appropriate PIT (Castro et al, 2005;Morales-delaNuez et al, 2009;Moreno-Indias et al, 2012). No references about the amount of colostrum required by newborn lambs reared under artificial conditions have been found.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, there is an increase in the number of high-production dairy farms, where lambs are reared under an artificial feeding system. In such cases, lambs are bottlefed colostrum and milk replacer in order to increase the amount of milk available for processing (Demiroren et al, 1995;Napolitano et al, 2008;David et al, 2014), thus simplifying animal management (Emsen et al, 2004).As it has been described by several authors, goat kids need to be fed an amount of colostrum equivalent to 4 g of IgG/kg of BW, divided into three meals before 48 h after birth, in order to make an appropriate PIT (Castro et al, 2005;Morales-delaNuez et al, 2009;Moreno-Indias et al, 2012). No references about the amount of colostrum required by newborn lambs reared under artificial conditions have been found.…”

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confidence: 99%

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The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Hernández-Castellano

Suárez-Trujillo

Martell-Jaizme

et al. 2015

Animal

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The aim of this study was to investigate the BW and immune status of lambs reared under natural conditions or under artificial conditions fed two different colostrum amounts. In this study, 60 lambs were randomly divided into groups according to treatment. Twenty lambs remained with their dams (natural rearing (NR) group). Forty lambs were removed from their dams at birth. Lambs were bottle-fed with a pool of sheep colostrum, receiving either 4 g of IgG/kg of BW at birth (C4 group) or 8 g of IgG/kg of BW at birth (C8 group). The total colostrum amount was equally divided into three meals at 2, 14 and 24 h after birth. After this period, lambs were bottle-fed a commercial milk replacer. Blood plasma sample analysis and BW recordings were carried out before feeding at birth and then at 1, 2, 3, 4, 5 and 20 days after birth. Another blood sample analysis and BW recording was carried out when animals reached 10 kg of BW. During weaning (30 days), sampling was carried out every 5 days. Blood plasma was used to determine the concentrations of IgG and IgM and the complement system activity -total and alternative pathways. The NR group showed greater BW than the C4 and C8 groups during milk feeding period, whereas the C4 and C8 groups had greater BW than the NR group at the end of weaning period. The C8 and NR groups had greater plasma IgG and IgM concentrations than the C4 group during milk feeding period. In addition, C4 and C8 groups showed similar IgG concentrations and greater IgM concentrations than the NR group at the end of the weaning period. Complement system activity was greater in the NR group than in the C4 and C8 groups during the first 3 days after birth. In conclusion, lambs fed amounts of colostrum equivalent to 8 g of IgG/kg of BW showed similar immune variables compared to lambs reared under natural conditions, obtaining a greater BW at the end of the weaning period. Nevertheless, this study shows that not only the colostrum amount but also the management during the milk feeding and weaning period, such as stress produced by dam separation, milk quality and suckling frequency, can affect the final immune status of lambs.Keywords: immune, lamb, colostrum, weaning, artificial rearing ImplicationsColostrum plays a fundamental role in the immunization of newborn ruminants. Artificial rearing is a common method used in dairy farms, increasing the amount of milk for processing. The aim of this study was to feed newborn lambs colostrum with two different IgG concentrations and to compare these animals to natural dam fed lambs. This study showed that administration of 8 g of immunoglobulin g/kg BW at birth, equally divided into three colostrum meals (2, 14 and 26 h), achieved higher circulating immunoglobulin G concentration when compared to the natural rearing treatment, although both artificial rearing groups decreased BW after birth. IntroductionThe relationship between colostrum and the survival of newborn ruminants has been long characterized (Argüello et al., 2004;Castro et al., 2011;Abdou et al., 2014)...

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Hernández-Castellano

Suárez-Trujillo

Martell-Jaizme

et al. 2015

Animal

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“…Haemolytic activity of complement system (HACS) was measured according to the procedure of Morales‐delaNuez et al. () with the following modifications. Washed equine red blood cells at 5% (20 μ l) were added to the blood‐EO solution supernatants (100 μ l) and incubated at 25 °C.…”

Section: Methodsmentioning

confidence: 99%

In vitro effects of plant essential oils on non‐specific immune parameters of red drum, Sciaenops ocellatus L.

Sutili

Gatlin

Rossi

et al. 2016

Animal Physiology Nutrition

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Phytochemicals such as plant essential oils (EOs) have been reported to favour various activities in the innate immune system of fish. Thus, the aim of this study was to verify the in vitro effect of three different plant EOs (Ocimum americanum, Cymbopogon flexuosus and Melaleuca alternifolia) on non-specific immune parameters and erythrocyte osmotic fragility of red drum, Sciaenops ocellatus. Concentrations of each plant EO evaluated in preparations of head-kidney macrophages, blood leucocytes and blood plasma were as follows: 0.0 (control), 1.0, 2.0, 4.0, 8.0, and 16.0 μg/ml. Red drum head-kidney macrophages significantly increased extracellular superoxide anion production when exposed (20 h) to O. americanum EO (1.0-8.0 μg/ml) and C. flexuosus EO (2.0 and 4.0 μg/ml). The respiratory burst of blood leucocytes (NBT test) significantly increased in all concentrations when compared to the respective control group, for all EOs. At the highest concentration (16.0 μg/ml), C. flexuosus EO significantly inhibited the haemolytic activity of complement system in red drum blood after 1 h exposure. None of the tested concentrations significantly altered plasma lysozyme activity or erythrocyte osmotic fragility after exposing (1 h) red drum whole blood to each EO. This study demonstrated that these plant EOs are capable of triggering superoxide anion production in red drum leucocytes (head-kidney macrophages and/or blood leucocytes). In vivo studies are warranted to address their potential as immunostimulants in the diet of red drum and other aquacultured species.

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“…The combination of these all provide effective protection surroundings within the animal [29,30]. The synergistic effects by various substances produced and secreted by colonized microbes in gut also join hands to already task of eliminating harmful parasites.…”

Section: Mechanisms For Immune Regulation In Gut In Parasitic Managementmentioning

confidence: 99%

“…Moreover, dendritic cells driven Th3 cells become sensitive to Myelin Basic Protein (MBP) that releases IL 10 and Transforming Growth Factor β (TGF β) [51]. Thus the presence of parasite enterprises to the autoantigen, resulting in inhibition of the process [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. It is further demonstrated that parasitic infection depletes some important generalized and specialized transcriptional factors that are essential to transcription.…”

Section: Mechanisms For Immune Regulation In Gut In Parasitic Managementmentioning

confidence: 99%

Parasitism in Goats: Husbandry Management, Range Management, Gut Immunity and Therapeutics

Ayaz¹,

Nazir²,

NoreenSamad³

et al. 2018

Goat Science

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Goats play a vital role in the economy of common man. It acts as pivotal point in the uplift of socio-economic status of females. The goats are such delicate and fragile animals that encounter a lot of infectious and non-infectious diseases including viruses, bacteria and gastrointestinal parasites (GIP). The goat being a range animal is selective feeder. It needs a lot of managemental practices which safeguards its health. This chapter focuses on management, impact of gastrointestinal parasites, role of intestinal immunity, various breeds reared in Pakistan, role of plant based phytochemicals to treat against GIT parasites and various models to predict the status of health in animals.

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Effects of a reputed immunostimulant on the innate immune system of goat kids

Cited by 11 publications

References 16 publications

The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

In vitro effects of plant essential oils on non‐specific immune parameters of red drum, Sciaenops ocellatus L.

Parasitism in Goats: Husbandry Management, Range Management, Gut Immunity and Therapeutics

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