Effects of a Single, Daily Alcoholic Beverage on Lipid and Hemostatic Markers of Cardiovascular Risk

McConnell, Michael V.; Vavouranakis, Ioannis; Wu, Lily; Vaughan, Douglas E.; Ridker, Paul M.

doi:10.1016/s0002-9149(97)00647-4

Cited by 39 publications

(23 citation statements)

References 20 publications

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“…23 Nevertheless, although previous studies demonstrated the beneficial effect of moderate alcohol consumption on hemostatic factors, the present results did not show any relationship with PAI-1. This is in agreement with previous reports showing little or no association between alcohol intake and PAI-1 24 and may indicate that proinflammatory cytokines are not involved in the known relation between ethanol and hemostatic factors. 4 The present study has several limitations.…”

Section: Discussionsupporting

confidence: 93%

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

et al. 2004

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Background-Increased levels of acute-phase reactants predict the onset of poor health outcomes. A U-shaped association has been reported between alcohol intake and health outcomes, which suggests that alcohol intake may modify levels of acute-phase reactants. We investigated the relationship between weekly alcohol intake and interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-␣ (TNF-␣), and plasminogen activator inhibitor-1 (PAI-1). Methods and Results-Data are from year 1 of the Health, Aging, and Body Composition study, a biracial cohort of 3075 well-functioning men and women aged 70 to 79 years, living in Memphis, Tenn, and Pittsburgh, Pa. The analysis included 2574 persons (51.2% women; 40.1% black) with complete data. After adjustment for age, race, smoking status, history of diabetes, history of cardiovascular disease, physical activity, high-density lipoprotein cholesterol, antiinflammatory medications, statins, and total fat mass, alcohol intake showed a J-shaped relationship with mean IL-6 (P for quadratic term Ͻ0.001) and CRP (Pϭ0.014) levels. The association was consistent in both men and women. Compared with subjects who consumed 1 to 7 drinks per week, those who never drank had an increased likelihood of having high levels of both IL-6 and CRP, as did those who drank 8 or more drinks per week. We found no relationship between alcohol intake and levels of TNF-␣ and PAI-1 (Pϭ0.137 and 0.08, respectively). Conclusions-In well-functioning older persons, light alcohol consumption is associated with lower levels of IL-6 and CRP. These results might suggest an additional biological explanation to the epidemiological link between moderate alcohol consumption and cardiovascular events.

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Section: Discussionsupporting

confidence: 93%

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

et al. 2004

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“…However, plasma triacylglycerol was unaffected by the wine when the meal was followed by a 15 h fasting period. This finding is in accordance with some long-term feeding studies which have failed to find any effect of moderate regular alcohol consumption on fasting plasma triacylglycerols in normal subjects (Hartung et al 1983;Couzigou et al 1984;Crouse & Grundy, 1984;McConnell et al 1997). However, recent meta-analysis of thirty-five human intervention studies with >6 d of alcohol administration revealed that alcohol consumption increased plasma triacylglycerol (Rimm et al 1999).…”

Section: Plasma Triacylglycerolsupporting

confidence: 88%

Alcohol drinking and cardiac risk

Buemann¹,

Dyerberg²,

Astrup³

2002

NRR

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The present paper provides a comprehensive review of the literature pertaining to the impact of alcohol intake on cardiovascular disease. Both cross-sectional and prospective studies have disclosed a negative association between moderate intake of alcoholic beverages and cardiovascular disease. The relationship appears to be present for both wine, beer and spirits. Effects of alcohol itself and also the role of different cardioprotective substances in alcoholic beverages are discussed. Alcohol has been suggested to beneficially affect the blood lipid profile, as it increases plasma HDL-cholesterol level. Furthermore, it may inhibit thrombogenesis by reducing thromboxan formation and decreasing the plasma level of fibrinogen. However, high blood concentrations of alcohol may impair fibrinolysis by increasing plasma plasminogen activator inhibitor-1 level. This action could contribute to explaining the 'U'-shaped association between alcohol intake and cardiac events. Alcohol seems to promote abdominal fat distribution, but the importance of this effect in non-obese individuals is uncertain. Wine in particular, but also beer, contains polyphenols which act as antioxidants. Their action could maintain the integrity of the endothelial function by reducing the formation of superoxide. Moreover, these antioxidants may protect against LDL oxidation and modulate the macrophage attack on the endothelium. Although the cardio-protective effect of alcohol can hardly be addressed in healthy individuals by intervention studies with hard end points, there are many observational and experimental findings indicating that moderate alcohol drinking possesses properties preventive of cardiovascular disease.

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“…Well known factors that have a beneficial effect on the abundance of apo AI protein include: physical excercise (Huttunen et al 1979, Ballantyne et al 1982, Danner et al 1984, alcohol consumption (McConnell et al 1997, Manttari et al 1997) and being female (Heiss et al 1980). These factors increase concentrations of apo AI protein.…”

Section: Introductionmentioning

confidence: 99%

Hormonal regulation of apolipoprotein AI

Hargrove¹,

Junco²,

Wong³

1999

Journal of Molecular Endocrinology

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Apolipoprotein AI (apo AI) is the major protein component of the serum high-density lipoprotein (HDL) particles. The antiatherogenic properties of apo AI alone or as part of HDL and their inverse correlation with the incidence of coronary heart disease underlie the clinical importance of the protein. A detailed understanding of the mechanisms by which apo AI is regulated will help us develop new and better ways to manipulate expression of the protein. Although there are many factors that influence apo AI expression, endogenous hormones are attractive because simple changes in abundance of these compounds will alter gene activity. Hormones belonging to the thyroid/steroid family that influence activity of the gene include thyroid hormone, glucocorticoids, gender-specific steroids and retinoic acid. Whereas thyroid, glucocorticoid and estradiol enhance activity of the gene, retinoic acid and androgens decrease it. The mechanisms that mediate the effects of the hormones include direct effects of the ligand and nuclear receptor complex on gene activity. However, indirect means involving the participation of transcription factors other than the hormone receptors are also possible. In summary, members of the same hormone family may have different mechanisms that mediate their activities on apo AI gene activity.

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Effects of a Single, Daily Alcoholic Beverage on Lipid and Hemostatic Markers of Cardiovascular Risk

Cited by 39 publications

References 20 publications

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

Alcohol drinking and cardiac risk

Hormonal regulation of apolipoprotein AI

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